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The role of tree nuts and peanuts in the prevention of coronary heart disease: multiple potential mechanisms.
J Nutr. 2008 Sep; 138(9):1746S-1751S.JN

Abstract

Epidemiologic and clinical trial evidence has demonstrated consistent benefits of nut and peanut consumption on coronary heart disease (CHD) risk and associated risk factors. The epidemiologic studies have reported various endpoints, including fatal CHD, total CHD death, total CHD, and nonfatal myocardial infarct. A pooled analysis of 4 U.S. epidemiologic studies showed that subjects in the highest intake group for nut consumption had an approximately 35% reduced risk of CHD incidence. The reduction in total CHD death was due primarily to a decrease in sudden cardiac death. Clinical studies have evaluated the effects of many different nuts and peanuts on lipids, lipoproteins, and various CHD risk factors, including oxidation, inflammation, and vascular reactivity. Evidence from these studies consistently shows a beneficial effect on these CHD risk factors. The LDL cholesterol-lowering response of nut and peanut studies is greater than expected on the basis of blood cholesterol-lowering equations that are derived from changes in the fatty acid profile of the diet. Thus, in addition to a favorable fatty acid profile, nuts and peanuts contain other bioactive compounds that explain their multiple cardiovascular benefits. Other macronutrients include plant protein and fiber; micronutrients including potassium, calcium, magnesium, and tocopherols; and phytochemicals such as phytosterols, phenolic compounds, resveratrol, and arginine. Nuts and peanuts are food sources that are a composite of numerous cardioprotective nutrients and if routinely incorporated in a healthy diet, population risk of CHD would therefore be expected to decrease markedly.

Authors+Show Affiliations

Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA. pmk3@psu.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18716180

Citation

Kris-Etherton, Penny M., et al. "The Role of Tree Nuts and Peanuts in the Prevention of Coronary Heart Disease: Multiple Potential Mechanisms." The Journal of Nutrition, vol. 138, no. 9, 2008, 1746S-1751S.
Kris-Etherton PM, Hu FB, Ros E, et al. The role of tree nuts and peanuts in the prevention of coronary heart disease: multiple potential mechanisms. J Nutr. 2008;138(9):1746S-1751S.
Kris-Etherton, P. M., Hu, F. B., Ros, E., & Sabaté, J. (2008). The role of tree nuts and peanuts in the prevention of coronary heart disease: multiple potential mechanisms. The Journal of Nutrition, 138(9), 1746S-1751S.
Kris-Etherton PM, et al. The Role of Tree Nuts and Peanuts in the Prevention of Coronary Heart Disease: Multiple Potential Mechanisms. J Nutr. 2008;138(9):1746S-1751S. PubMed PMID: 18716180.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of tree nuts and peanuts in the prevention of coronary heart disease: multiple potential mechanisms. AU - Kris-Etherton,Penny M, AU - Hu,Frank B, AU - Ros,Emilio, AU - Sabaté,Joan, PY - 2008/8/22/pubmed PY - 2008/9/17/medline PY - 2008/8/22/entrez SP - 1746S EP - 1751S JF - The Journal of nutrition JO - J Nutr VL - 138 IS - 9 N2 - Epidemiologic and clinical trial evidence has demonstrated consistent benefits of nut and peanut consumption on coronary heart disease (CHD) risk and associated risk factors. The epidemiologic studies have reported various endpoints, including fatal CHD, total CHD death, total CHD, and nonfatal myocardial infarct. A pooled analysis of 4 U.S. epidemiologic studies showed that subjects in the highest intake group for nut consumption had an approximately 35% reduced risk of CHD incidence. The reduction in total CHD death was due primarily to a decrease in sudden cardiac death. Clinical studies have evaluated the effects of many different nuts and peanuts on lipids, lipoproteins, and various CHD risk factors, including oxidation, inflammation, and vascular reactivity. Evidence from these studies consistently shows a beneficial effect on these CHD risk factors. The LDL cholesterol-lowering response of nut and peanut studies is greater than expected on the basis of blood cholesterol-lowering equations that are derived from changes in the fatty acid profile of the diet. Thus, in addition to a favorable fatty acid profile, nuts and peanuts contain other bioactive compounds that explain their multiple cardiovascular benefits. Other macronutrients include plant protein and fiber; micronutrients including potassium, calcium, magnesium, and tocopherols; and phytochemicals such as phytosterols, phenolic compounds, resveratrol, and arginine. Nuts and peanuts are food sources that are a composite of numerous cardioprotective nutrients and if routinely incorporated in a healthy diet, population risk of CHD would therefore be expected to decrease markedly. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/18716180/The_role_of_tree_nuts_and_peanuts_in_the_prevention_of_coronary_heart_disease:_multiple_potential_mechanisms_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/138.9.1746S DB - PRIME DP - Unbound Medicine ER -
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