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Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin.
Int J Dermatol. 2008 Aug; 47(8):812-9.IJ

Abstract

BACKGROUND

Stratum corneum intercellular lipids, such as ceramides, play an important role in the regulation of skin water barrier homeostasis and water-holding capacity. Aim To evaluate the potential water retention capacity of control emulsion and three oil-in-water (o/w) emulsions containing ceramide 1, ceramide 3, or both.

METHODS

Fifteen healthy Asian women (age, 20-30 years) with healthy skin, pretreated with sodium lauryl sulfate (SLS), applied the tested emulsions twice daily over a period of 28 days. Skin hydration and transepidermal water loss (TEWL) values were measured on the indicated days with a Corneometer(R)825 and a TEWAMETER TM210, respectively.

RESULTS

The maximum increase in skin humidity was reached after 4 weeks, with values of 21.9 +/- 1.8% and 8.9 +/- 0.9% for emulsion C and control emulsion, respectively. The maximum decrease in TEWL was also reached after 4 weeks, with values of 36.7 +/- 4.7% and 5.1 +/- 0.8% for the same emulsions.

CONCLUSIONS

It can be concluded that all the tested ceramide-containing emulsions improved skin barrier function when compared with untreated skin. There was some indication that ceramides 1 and 3 contained in emulsion C might exert a beneficial synergistic effect on skin biochemical properties, such as skin hydration and TEWL, and play a key role in the protection mechanism against SLS irritation.

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Authors+Show Affiliations

Huang HC
Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan.
Chang TM
No affiliation info available

MeSH

AdultBody WaterCeramidesCohort StudiesDermatitis, IrritantDrug SynergismEmulsionsFemaleGlycosphingolipidsHumansReference ValuesRisk FactorsSensitivity and SpecificitySkin AbsorptionSkin Physiological PhenomenaSodium Dodecyl SulfateWater Loss, Insensible

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18717861

Citation

Huang, Huey-Chun, and Tsong-Min Chang. "Ceramide 1 and Ceramide 3 Act Synergistically On Skin Hydration and the Transepidermal Water Loss of Sodium Lauryl Sulfate-irritated Skin." International Journal of Dermatology, vol. 47, no. 8, 2008, pp. 812-9.
Huang HC, Chang TM. Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin. Int J Dermatol. 2008;47(8):812-9.
Huang, H. C., & Chang, T. M. (2008). Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin. International Journal of Dermatology, 47(8), 812-9. https://doi.org/10.1111/j.1365-4632.2008.03687.x
Huang HC, Chang TM. Ceramide 1 and Ceramide 3 Act Synergistically On Skin Hydration and the Transepidermal Water Loss of Sodium Lauryl Sulfate-irritated Skin. Int J Dermatol. 2008;47(8):812-9. PubMed PMID: 18717861.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin. AU - Huang,Huey-Chun, AU - Chang,Tsong-Min, PY - 2008/8/23/pubmed PY - 2008/11/18/medline PY - 2008/8/23/entrez SP - 812 EP - 9 JF - International journal of dermatology JO - Int J Dermatol VL - 47 IS - 8 N2 - BACKGROUND: Stratum corneum intercellular lipids, such as ceramides, play an important role in the regulation of skin water barrier homeostasis and water-holding capacity. Aim To evaluate the potential water retention capacity of control emulsion and three oil-in-water (o/w) emulsions containing ceramide 1, ceramide 3, or both. METHODS: Fifteen healthy Asian women (age, 20-30 years) with healthy skin, pretreated with sodium lauryl sulfate (SLS), applied the tested emulsions twice daily over a period of 28 days. Skin hydration and transepidermal water loss (TEWL) values were measured on the indicated days with a Corneometer(R)825 and a TEWAMETER TM210, respectively. RESULTS: The maximum increase in skin humidity was reached after 4 weeks, with values of 21.9 +/- 1.8% and 8.9 +/- 0.9% for emulsion C and control emulsion, respectively. The maximum decrease in TEWL was also reached after 4 weeks, with values of 36.7 +/- 4.7% and 5.1 +/- 0.8% for the same emulsions. CONCLUSIONS: It can be concluded that all the tested ceramide-containing emulsions improved skin barrier function when compared with untreated skin. There was some indication that ceramides 1 and 3 contained in emulsion C might exert a beneficial synergistic effect on skin biochemical properties, such as skin hydration and TEWL, and play a key role in the protection mechanism against SLS irritation. SN - 1365-4632 UR - https://www.unboundmedicine.com/medline/citation/18717861/Ceramide_1_and_ceramide_3_act_synergistically_on_skin_hydration_and_the_transepidermal_water_loss_of_sodium_lauryl_sulfate_irritated_skin_ L2 - https://doi.org/10.1111/j.1365-4632.2008.03687.x DB - PRIME DP - Unbound Medicine ER -