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[Hemostatic effect of hemocoagulase agkistrodon and its mechanism].
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Aug; 16(4):883-5.ZS

Abstract

This study was aimed to investigate the hemostatic effects of hemocoagulase agkistrodon (HCA) and its mechanism. The procoagulative and hemostatic effects of HCA were evaluated by using rabbit blood coagulatin time and mouse tail bleeding time; the mechanisms of HCA hemostatic effect were analyzed by using rabbit blood clot lysis and fibrinogen lysis. The results showed that HCA shortened the rabbit blood coagulation time and the mouse tail bleeding time significantly. The effects are nearly similar to that of positive control (reptilase). HCA also induced rabbit blood clot lysis and directly hydrolysed the alpha-chain of fibrinogen. It is concluded that HCA exert its hemostatic effects by hydrolysing the alpha-chain of fibrinogen, but it is not able to induce production of XIII factor.

Authors+Show Affiliations

National Institute of Radiological Protection and Nuclear Safety, Chinese Center for Disease Control and Prevention, Beijing 100080, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

18718083

Citation

Lü, Hui-Min, et al. "[Hemostatic Effect of Hemocoagulase Agkistrodon and Its Mechanism]." Zhongguo Shi Yan Xue Ye Xue Za Zhi, vol. 16, no. 4, 2008, pp. 883-5.
Lü HM, Li CL, Dong JC, et al. [Hemostatic effect of hemocoagulase agkistrodon and its mechanism]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008;16(4):883-5.
Lü, H. M., Li, C. L., Dong, J. C., Zhang, C. L., & Zhou, X. Y. (2008). [Hemostatic effect of hemocoagulase agkistrodon and its mechanism]. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 16(4), 883-5.
Lü HM, et al. [Hemostatic Effect of Hemocoagulase Agkistrodon and Its Mechanism]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008;16(4):883-5. PubMed PMID: 18718083.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Hemostatic effect of hemocoagulase agkistrodon and its mechanism]. AU - Lü,Hui-Min, AU - Li,Chang-Ling, AU - Dong,Jin-Chan, AU - Zhang,Cui-Lan, AU - Zhou,Xiang-Yan, PY - 2008/8/23/pubmed PY - 2010/1/13/medline PY - 2008/8/23/entrez SP - 883 EP - 5 JF - Zhongguo shi yan xue ye xue za zhi JO - Zhongguo Shi Yan Xue Ye Xue Za Zhi VL - 16 IS - 4 N2 - This study was aimed to investigate the hemostatic effects of hemocoagulase agkistrodon (HCA) and its mechanism. The procoagulative and hemostatic effects of HCA were evaluated by using rabbit blood coagulatin time and mouse tail bleeding time; the mechanisms of HCA hemostatic effect were analyzed by using rabbit blood clot lysis and fibrinogen lysis. The results showed that HCA shortened the rabbit blood coagulation time and the mouse tail bleeding time significantly. The effects are nearly similar to that of positive control (reptilase). HCA also induced rabbit blood clot lysis and directly hydrolysed the alpha-chain of fibrinogen. It is concluded that HCA exert its hemostatic effects by hydrolysing the alpha-chain of fibrinogen, but it is not able to induce production of XIII factor. SN - 1009-2137 UR - https://www.unboundmedicine.com/medline/citation/18718083/[Hemostatic_effect_of_hemocoagulase_agkistrodon_and_its_mechanism]_ DB - PRIME DP - Unbound Medicine ER -