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Acute generalized exanthematous pustulosis due to clindamycin.
Dermatol Online J. 2008 Jul 15; 14(7):14.DO

Abstract

Acute generalized exanthematous pustulosis (AGEP) is a rare skin eruption most commonly caused by medications. It is characterized by fever and the acute eruption of non-follicular pustules overlying erythrodermic skin. Histopathology shows subcorneal pustules with a background of dermal edema and spongiosis, leukocytoclastic vasculitis, perivascular eosinophils, and focal necrosis of keratinocytes. Three cases of clindamycin induced AGEP have been reported in the literature. A case of AGEP due to clindamycin is reported in a patient with numerous other drug allergies and without history of psoriasis. Presentation and treatment of AGEP are reviewed.

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Authors+Show Affiliations

Sulewski RJ
Resurrection Hospital, Chicago, IL, USA.
Blyumin M
No affiliation info available
Kerdel FA
No affiliation info available

MeSH

Acute DiseaseAged, 80 and overBiopsy, NeedleClindamycinCombined Modality TherapyDrug EruptionsExanthemaFemaleFollow-Up StudiesHumansImmunohistochemistryRare DiseasesRisk AssessmentSeverity of Illness IndexSkin Diseases, PapulosquamousTreatment Outcome

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

18718198

Citation

Sulewski, Ronald J., et al. "Acute Generalized Exanthematous Pustulosis Due to Clindamycin." Dermatology Online Journal, vol. 14, no. 7, 2008, p. 14.
Sulewski RJ, Blyumin M, Kerdel FA. Acute generalized exanthematous pustulosis due to clindamycin. Dermatol Online J. 2008;14(7):14.
Sulewski, R. J., Blyumin, M., & Kerdel, F. A. (2008). Acute generalized exanthematous pustulosis due to clindamycin. Dermatology Online Journal, 14(7), 14.
Sulewski RJ, Blyumin M, Kerdel FA. Acute Generalized Exanthematous Pustulosis Due to Clindamycin. Dermatol Online J. 2008 Jul 15;14(7):14. PubMed PMID: 18718198.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute generalized exanthematous pustulosis due to clindamycin. AU - Sulewski,Ronald J,Jr AU - Blyumin,Marianna, AU - Kerdel,Francisco A, Y1 - 2008/07/15/ PY - 2008/8/23/pubmed PY - 2008/11/15/medline PY - 2008/8/23/entrez SP - 14 EP - 14 JF - Dermatology online journal JO - Dermatol Online J VL - 14 IS - 7 N2 - Acute generalized exanthematous pustulosis (AGEP) is a rare skin eruption most commonly caused by medications. It is characterized by fever and the acute eruption of non-follicular pustules overlying erythrodermic skin. Histopathology shows subcorneal pustules with a background of dermal edema and spongiosis, leukocytoclastic vasculitis, perivascular eosinophils, and focal necrosis of keratinocytes. Three cases of clindamycin induced AGEP have been reported in the literature. A case of AGEP due to clindamycin is reported in a patient with numerous other drug allergies and without history of psoriasis. Presentation and treatment of AGEP are reviewed. SN - 1087-2108 UR - https://www.unboundmedicine.com/medline/citation/18718198/Acute_generalized_exanthematous_pustulosis_due_to_clindamycin_ L2 - http://dermatology.cdlib.org/147/case_presentation/agep/blyumin.html DB - PRIME DP - Unbound Medicine ER -