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Extraocular proprioception and new treatments for infantile nystagmus syndrome.
Prog Brain Res. 2008; 171:67-75.PB

Abstract

Our goal is to develop the proprioceptive hypothesis for nystagmus damping; and present the resulting therapies for the treatment of infantile nystagmus syndrome (INS) and acquired nystagmus. Contact lenses, cutaneous stimulation, and neck-muscle vibration damped INS. Four-muscle tenotomy and reattachment was hypothesized as a treatment for INS in 1979 and successfully demonstrated to improve foveation in a canine model of INS and seesaw nystagmus in 1998 and in humans with INS (masked-data, NEI Clinical Trial) in 2003. Subsequently, tenotomy successfully damped acquired pendular nystagmus and oscillopsia in two MS patients and downbeat nystagmus in another. Tenotomy, used in isolation or combination with existing nystagmus and strabismus surgeries, damps different types of nystagmus in their plane of action. Recent neuroanatomical and neurophysiological discoveries support the hypothesis that proprioception is the mechanism for INS damping and allow more realistic models of peripheral ocular motor pathways.

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Authors+Show Affiliations

Dell'Osso LF
Daroff-Dell'Osso Ocular Motility Laboratory, Louis Stokes Cleveland Department of Veterans Affairs Medical Center and CASE Medical School, Cleveland, OH, USA. lfd@case.edu
Wang ZI
No affiliation info available

MeSH

Afferent PathwaysAnimalsConvergence, OcularDogsEfferent PathwaysEye MovementsHumansModels, BiologicalNystagmus, CongenitalOculomotor MusclesProprioception

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

18718284

Citation

Dell'Osso, L F., and Z I. Wang. "Extraocular Proprioception and New Treatments for Infantile Nystagmus Syndrome." Progress in Brain Research, vol. 171, 2008, pp. 67-75.
Dell'Osso LF, Wang ZI. Extraocular proprioception and new treatments for infantile nystagmus syndrome. Prog Brain Res. 2008;171:67-75.
Dell'Osso, L. F., & Wang, Z. I. (2008). Extraocular proprioception and new treatments for infantile nystagmus syndrome. Progress in Brain Research, 171, 67-75. https://doi.org/10.1016/S0079-6123(08)00610-9
Dell'Osso LF, Wang ZI. Extraocular Proprioception and New Treatments for Infantile Nystagmus Syndrome. Prog Brain Res. 2008;171:67-75. PubMed PMID: 18718284.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Extraocular proprioception and new treatments for infantile nystagmus syndrome. AU - Dell'Osso,L F, AU - Wang,Z I, PY - 2008/8/23/pubmed PY - 2009/1/16/medline PY - 2008/8/23/entrez SP - 67 EP - 75 JF - Progress in brain research JO - Prog Brain Res VL - 171 N2 - Our goal is to develop the proprioceptive hypothesis for nystagmus damping; and present the resulting therapies for the treatment of infantile nystagmus syndrome (INS) and acquired nystagmus. Contact lenses, cutaneous stimulation, and neck-muscle vibration damped INS. Four-muscle tenotomy and reattachment was hypothesized as a treatment for INS in 1979 and successfully demonstrated to improve foveation in a canine model of INS and seesaw nystagmus in 1998 and in humans with INS (masked-data, NEI Clinical Trial) in 2003. Subsequently, tenotomy successfully damped acquired pendular nystagmus and oscillopsia in two MS patients and downbeat nystagmus in another. Tenotomy, used in isolation or combination with existing nystagmus and strabismus surgeries, damps different types of nystagmus in their plane of action. Recent neuroanatomical and neurophysiological discoveries support the hypothesis that proprioception is the mechanism for INS damping and allow more realistic models of peripheral ocular motor pathways. SN - 1875-7855 UR - https://www.unboundmedicine.com/medline/citation/18718284/Extraocular_proprioception_and_new_treatments_for_infantile_nystagmus_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0079-6123(08)00610-9 DB - PRIME DP - Unbound Medicine ER -