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Maternal glucose tolerance status influences the risk of macrosomia in male but not in female fetuses.
J Epidemiol Community Health. 2009 Jan; 63(1):64-8.JE

Abstract

OBJECTIVE

To elucidate whether the risk of macrosomia, large for gestational age (LGA) and small for gestational age (SGA) is influenced by maternal body mass index and glucose tolerance differently in male and female fetuses.

METHODS

A population study was conducted in 16 general hospitals from the Spanish National Health Service that included 9270 consecutive women with singleton pregnancies and without a former diagnosis of diabetes mellitus who delivered 4793 male and 4477 female newborns. Logistic regression analyses were performed to predict the effect of body mass index (BMI) category and glucose tolerance on macrosomia, large for gestational age newborns (LGA) and small for gestational age newborns (SGA) Separate analyses according to foetal sex were carried out for each outcome. The results were adjusted for maternal age, gestational age and pregnancy-induced hypertension.

RESULTS

There were significant differences between males and females in the percentage of infants who had macrosomia, LGA or SGA. Maternal BMI category was positively associated with the risk of macrosomia and LGA in both male and female newborns. In addition, there was a negative association between maternal BMI and SGA that only reached significance in males. In contrast, gestational diabetes was only a predictor of macrosomia exclusively in male fetuses (OR 1.67, 95% CI 1.12 to 2.49)

CONCLUSIONS

There is sexual dimorphism in the risk of abnormal birth weight attributed to maternal glucose tolerance status. A closer surveillance of foetal growth might be warranted in pregnant women with abnormal glucose tolerance carrying a male fetus.

Authors+Show Affiliations

Hospital Universitari de Girona Doctor Josep Trueta, Girona, IdlBGi, CIBER Fisiopatologia de la Obesidad y Nutrició, Spain. uden.wricart@htrueta.scs.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18718980

Citation

Ricart, W, et al. "Maternal Glucose Tolerance Status Influences the Risk of Macrosomia in Male but Not in Female Fetuses." Journal of Epidemiology and Community Health, vol. 63, no. 1, 2009, pp. 64-8.
Ricart W, López J, Mozas J, et al. Maternal glucose tolerance status influences the risk of macrosomia in male but not in female fetuses. J Epidemiol Community Health. 2009;63(1):64-8.
Ricart, W., López, J., Mozas, J., Pericot, A., Sancho, M. A., González, N., Balsells, M., Luna, R., Cortázar, A., Navarro, P., Ramírez, O., Flández, B., Pallardo, L. F., Hernández, A., Ampudia, J., Fernández-Real, J. M., Hernández-Aguado, I., & Corcoy, R. (2009). Maternal glucose tolerance status influences the risk of macrosomia in male but not in female fetuses. Journal of Epidemiology and Community Health, 63(1), 64-8. https://doi.org/10.1136/jech.2008.074542
Ricart W, et al. Maternal Glucose Tolerance Status Influences the Risk of Macrosomia in Male but Not in Female Fetuses. J Epidemiol Community Health. 2009;63(1):64-8. PubMed PMID: 18718980.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal glucose tolerance status influences the risk of macrosomia in male but not in female fetuses. AU - Ricart,W, AU - López,J, AU - Mozas,J, AU - Pericot,A, AU - Sancho,M A, AU - González,N, AU - Balsells,M, AU - Luna,R, AU - Cortázar,A, AU - Navarro,P, AU - Ramírez,O, AU - Flández,B, AU - Pallardo,L F, AU - Hernández,A, AU - Ampudia,J, AU - Fernández-Real,J M, AU - Hernández-Aguado,I, AU - Corcoy,R, AU - ,, Y1 - 2008/08/21/ PY - 2008/8/23/entrez PY - 2008/8/23/pubmed PY - 2009/11/10/medline SP - 64 EP - 8 JF - Journal of epidemiology and community health JO - J Epidemiol Community Health VL - 63 IS - 1 N2 - OBJECTIVE: To elucidate whether the risk of macrosomia, large for gestational age (LGA) and small for gestational age (SGA) is influenced by maternal body mass index and glucose tolerance differently in male and female fetuses. METHODS: A population study was conducted in 16 general hospitals from the Spanish National Health Service that included 9270 consecutive women with singleton pregnancies and without a former diagnosis of diabetes mellitus who delivered 4793 male and 4477 female newborns. Logistic regression analyses were performed to predict the effect of body mass index (BMI) category and glucose tolerance on macrosomia, large for gestational age newborns (LGA) and small for gestational age newborns (SGA) Separate analyses according to foetal sex were carried out for each outcome. The results were adjusted for maternal age, gestational age and pregnancy-induced hypertension. RESULTS: There were significant differences between males and females in the percentage of infants who had macrosomia, LGA or SGA. Maternal BMI category was positively associated with the risk of macrosomia and LGA in both male and female newborns. In addition, there was a negative association between maternal BMI and SGA that only reached significance in males. In contrast, gestational diabetes was only a predictor of macrosomia exclusively in male fetuses (OR 1.67, 95% CI 1.12 to 2.49) CONCLUSIONS: There is sexual dimorphism in the risk of abnormal birth weight attributed to maternal glucose tolerance status. A closer surveillance of foetal growth might be warranted in pregnant women with abnormal glucose tolerance carrying a male fetus. SN - 1470-2738 UR - https://www.unboundmedicine.com/medline/citation/18718980/Maternal_glucose_tolerance_status_influences_the_risk_of_macrosomia_in_male_but_not_in_female_fetuses_ L2 - https://jech.bmj.com/lookup/pmidlookup?view=long&pmid=18718980 DB - PRIME DP - Unbound Medicine ER -