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Neurocognitive performance during acute THC intoxication in heavy and occasional cannabis users.
J Psychopharmacol 2009; 23(3):266-77JP

Abstract

Performance impairment during Delta(9)-tetrahydrocannabinol (THC) intoxication has been well described in occasional cannabis users. It is less clear whether tolerance develops to the impairing effects of THC in heavy users of cannabis. The aim of the present study was to assess neurocognitive performance during acute THC intoxication in occasional and heavy users. Twenty-four subjects (12 occasional cannabis users and 12 heavy cannabis users) participated in a double-blind, placebo-controlled, two-way mixed model design. Both groups received single doses of THC placebo and 500 microg/kg THC by smoking. Performance tests were conducted at regular intervals between 0 and 8 h after smoking, and included measures of perceptual motor control (critical tracking task), dual task processing (divided attention task), motor inhibition (stop signal task) and cognition (Tower of London). THC significantly impaired performance of occasional cannabis users on critical tracking, divided attention and the stop signal task. THC did not affect the performance of heavy cannabis users except in the stop signal task, i.e. stop reaction time increased, particularly at high THC concentrations. Group comparisons of overall performance in occasional and heavy users did not reveal any persistent performance differences due to residual THC in heavy users. These data indicate that cannabis use history strongly determines the behavioural response to single doses of THC.

Authors+Show Affiliations

Department of Neuropsychology and Psychopharmacology, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands. j.ramaekers@psychology.unimaas.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18719045

Citation

Ramaekers, J G., et al. "Neurocognitive Performance During Acute THC Intoxication in Heavy and Occasional Cannabis Users." Journal of Psychopharmacology (Oxford, England), vol. 23, no. 3, 2009, pp. 266-77.
Ramaekers JG, Kauert G, Theunissen EL, et al. Neurocognitive performance during acute THC intoxication in heavy and occasional cannabis users. J Psychopharmacol (Oxford). 2009;23(3):266-77.
Ramaekers, J. G., Kauert, G., Theunissen, E. L., Toennes, S. W., & Moeller, M. R. (2009). Neurocognitive performance during acute THC intoxication in heavy and occasional cannabis users. Journal of Psychopharmacology (Oxford, England), 23(3), pp. 266-77. doi:10.1177/0269881108092393.
Ramaekers JG, et al. Neurocognitive Performance During Acute THC Intoxication in Heavy and Occasional Cannabis Users. J Psychopharmacol (Oxford). 2009;23(3):266-77. PubMed PMID: 18719045.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurocognitive performance during acute THC intoxication in heavy and occasional cannabis users. AU - Ramaekers,J G, AU - Kauert,G, AU - Theunissen,E L, AU - Toennes,S W, AU - Moeller,M R, Y1 - 2008/08/21/ PY - 2008/8/23/pubmed PY - 2009/7/10/medline PY - 2008/8/23/entrez SP - 266 EP - 77 JF - Journal of psychopharmacology (Oxford, England) JO - J. Psychopharmacol. (Oxford) VL - 23 IS - 3 N2 - Performance impairment during Delta(9)-tetrahydrocannabinol (THC) intoxication has been well described in occasional cannabis users. It is less clear whether tolerance develops to the impairing effects of THC in heavy users of cannabis. The aim of the present study was to assess neurocognitive performance during acute THC intoxication in occasional and heavy users. Twenty-four subjects (12 occasional cannabis users and 12 heavy cannabis users) participated in a double-blind, placebo-controlled, two-way mixed model design. Both groups received single doses of THC placebo and 500 microg/kg THC by smoking. Performance tests were conducted at regular intervals between 0 and 8 h after smoking, and included measures of perceptual motor control (critical tracking task), dual task processing (divided attention task), motor inhibition (stop signal task) and cognition (Tower of London). THC significantly impaired performance of occasional cannabis users on critical tracking, divided attention and the stop signal task. THC did not affect the performance of heavy cannabis users except in the stop signal task, i.e. stop reaction time increased, particularly at high THC concentrations. Group comparisons of overall performance in occasional and heavy users did not reveal any persistent performance differences due to residual THC in heavy users. These data indicate that cannabis use history strongly determines the behavioural response to single doses of THC. SN - 0269-8811 UR - https://www.unboundmedicine.com/medline/citation/18719045/full_citation/Neurocognitive_performance_during_acute_THC_intoxication_in_heavy_and_occasional_cannabis_users_ L2 - http://journals.sagepub.com/doi/full/10.1177/0269881108092393?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -