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The realistic yield of lower leg SNAP amplitudes and SRAR in the routine evaluation of chronic axonal polyneuropathies.
J Neurol. 2008 Aug; 255(8):1127-35.JN

Abstract

OBJECTIVE

To assess the realistic yield of lower leg sensory nerve action potential amplitudes (SNAP) and the sural/radial nerve amplitude ratio (SRAR) in the routine evaluation of suspected distal axonal polyneuropathy.

METHODS

Investigated were 721 people. In 393 referents without and 328 patients with chronic distal symmetrical polyneuropathy the SRAR, sural, superficial peroneal and dorsal sural SNAP were determined.

RESULTS

The dorsal sural SNAP could not be elicited in 26 % of referents. Axonal polyneuropathy was confirmed by an abnormally low value of the sural or superficial peroneal SNAP or SRAR in 70 % of patients, and most often (68 %) by an absent sural or superficial peroneal SNAP. In 9 % of patients there was a normal sural but abnormal superficial peroneal SNAP, and 11 % had an abnormal sural but normal superficial peroneal SNAP. ROC curve analysis demonstrated equal accuracy of the sural and superficial peroneal SNAP.

CONCLUSIONS

To confirm distal axonal polyneuropathy in routine clinical practice the sural and superficial peroneal SNAP had equal and complementary yield, whereas the SRAR and dorsal sural SNAP had limited additional yield.

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Authors+Show Affiliations

Vrancken AF
Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht,Dept. of Neurology C03.236, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. a.f.j.e.vrancken@umcutrecht.nl
Notermans NC
No affiliation info available
Wokke JH
No affiliation info available
Franssen H
No affiliation info available

MeSH

Action PotentialsAdolescentAdultAge FactorsAgedAged, 80 and overArea Under CurveElectric StimulationFemaleHumansLegMaleMiddle AgedNeural ConductionPeripheral Nervous System DiseasesRadial NerveRetrospective StudiesStatistics, NonparametricSural NerveYoung Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18719962

Citation

Vrancken, A F J E., et al. "The Realistic Yield of Lower Leg SNAP Amplitudes and SRAR in the Routine Evaluation of Chronic Axonal Polyneuropathies." Journal of Neurology, vol. 255, no. 8, 2008, pp. 1127-35.
Vrancken AF, Notermans NC, Wokke JH, et al. The realistic yield of lower leg SNAP amplitudes and SRAR in the routine evaluation of chronic axonal polyneuropathies. J Neurol. 2008;255(8):1127-35.
Vrancken, A. F., Notermans, N. C., Wokke, J. H., & Franssen, H. (2008). The realistic yield of lower leg SNAP amplitudes and SRAR in the routine evaluation of chronic axonal polyneuropathies. Journal of Neurology, 255(8), 1127-35. https://doi.org/10.1007/s00415-008-0817-7
Vrancken AF, et al. The Realistic Yield of Lower Leg SNAP Amplitudes and SRAR in the Routine Evaluation of Chronic Axonal Polyneuropathies. J Neurol. 2008;255(8):1127-35. PubMed PMID: 18719962.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The realistic yield of lower leg SNAP amplitudes and SRAR in the routine evaluation of chronic axonal polyneuropathies. AU - Vrancken,A F J E, AU - Notermans,N C, AU - Wokke,J H J, AU - Franssen,H, Y1 - 2008/08/24/ PY - 2007/08/21/received PY - 2007/11/13/accepted PY - 2007/11/02/revised PY - 2008/8/23/pubmed PY - 2009/4/15/medline PY - 2008/8/23/entrez SP - 1127 EP - 35 JF - Journal of neurology JO - J Neurol VL - 255 IS - 8 N2 - OBJECTIVE: To assess the realistic yield of lower leg sensory nerve action potential amplitudes (SNAP) and the sural/radial nerve amplitude ratio (SRAR) in the routine evaluation of suspected distal axonal polyneuropathy. METHODS: Investigated were 721 people. In 393 referents without and 328 patients with chronic distal symmetrical polyneuropathy the SRAR, sural, superficial peroneal and dorsal sural SNAP were determined. RESULTS: The dorsal sural SNAP could not be elicited in 26 % of referents. Axonal polyneuropathy was confirmed by an abnormally low value of the sural or superficial peroneal SNAP or SRAR in 70 % of patients, and most often (68 %) by an absent sural or superficial peroneal SNAP. In 9 % of patients there was a normal sural but abnormal superficial peroneal SNAP, and 11 % had an abnormal sural but normal superficial peroneal SNAP. ROC curve analysis demonstrated equal accuracy of the sural and superficial peroneal SNAP. CONCLUSIONS: To confirm distal axonal polyneuropathy in routine clinical practice the sural and superficial peroneal SNAP had equal and complementary yield, whereas the SRAR and dorsal sural SNAP had limited additional yield. SN - 0340-5354 UR - https://www.unboundmedicine.com/medline/citation/18719962/The_realistic_yield_of_lower_leg_SNAP_amplitudes_and_SRAR_in_the_routine_evaluation_of_chronic_axonal_polyneuropathies_ L2 - https://dx.doi.org/10.1007/s00415-008-0817-7 DB - PRIME DP - Unbound Medicine ER -