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Bioactive asterric acid derivatives from the Antarctic ascomycete fungus Geomyces sp.
J Nat Prod. 2008 Sep; 71(9):1643-6.JN

Abstract

Five new asterric acid derivatives, ethyl asterrate (3), n-butyl asterrate (4), and geomycins A-C (6-8), have been isolated from cultures of an isolate of the Antarctic ascomycete fungus Geomyces sp. The structures of these metabolites were elucidated by NMR spectroscopy. The absolute configuration of 8 was determined by application of the CD excitation chirality method. Compound 7 displayed antifungal activity against Aspergillus fumigatus, whereas 8 showed antimicrobial activities against gram-positive and gram-negative bacteria.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Li Y
Key Laboratory of Systematic Mycology and Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, People's Republic of China.
Sun B
No affiliation info available
Liu S
No affiliation info available
Jiang L
No affiliation info available
Liu X
No affiliation info available
Zhang H
No affiliation info available
Che Y
No affiliation info available

MeSH

Antifungal AgentsAscomycotaAspergillus fumigatusGram-Negative BacteriaGram-Positive BacteriaMicrobial Sensitivity TestsMolecular StructureNuclear Magnetic Resonance, BiomolecularPhenolsPhenyl Ethers

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18720971

Citation

Li, Yan, et al. "Bioactive Asterric Acid Derivatives From the Antarctic Ascomycete Fungus Geomyces Sp." Journal of Natural Products, vol. 71, no. 9, 2008, pp. 1643-6.
Li Y, Sun B, Liu S, et al. Bioactive asterric acid derivatives from the Antarctic ascomycete fungus Geomyces sp. J Nat Prod. 2008;71(9):1643-6.
Li, Y., Sun, B., Liu, S., Jiang, L., Liu, X., Zhang, H., & Che, Y. (2008). Bioactive asterric acid derivatives from the Antarctic ascomycete fungus Geomyces sp. Journal of Natural Products, 71(9), 1643-6. https://doi.org/10.1021/np8003003
Li Y, et al. Bioactive Asterric Acid Derivatives From the Antarctic Ascomycete Fungus Geomyces Sp. J Nat Prod. 2008;71(9):1643-6. PubMed PMID: 18720971.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioactive asterric acid derivatives from the Antarctic ascomycete fungus Geomyces sp. AU - Li,Yan, AU - Sun,Bingda, AU - Liu,Shuchun, AU - Jiang,Lihua, AU - Liu,Xingzhong, AU - Zhang,Hua, AU - Che,Yongsheng, Y1 - 2008/08/23/ PY - 2008/8/30/pubmed PY - 2008/11/13/medline PY - 2008/8/30/entrez SP - 1643 EP - 6 JF - Journal of natural products JO - J Nat Prod VL - 71 IS - 9 N2 - Five new asterric acid derivatives, ethyl asterrate (3), n-butyl asterrate (4), and geomycins A-C (6-8), have been isolated from cultures of an isolate of the Antarctic ascomycete fungus Geomyces sp. The structures of these metabolites were elucidated by NMR spectroscopy. The absolute configuration of 8 was determined by application of the CD excitation chirality method. Compound 7 displayed antifungal activity against Aspergillus fumigatus, whereas 8 showed antimicrobial activities against gram-positive and gram-negative bacteria. SN - 1520-6025 UR - https://www.unboundmedicine.com/medline/citation/18720971/Bioactive_asterric_acid_derivatives_from_the_Antarctic_ascomycete_fungus_Geomyces_sp_ L2 - https://doi.org/10.1021/np8003003 DB - PRIME DP - Unbound Medicine ER -