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Lymphovascular invasion is an independent predictor of prostate-specific antigen failure after radical prostatectomy in patients with pT3aN0 prostate cancer.
Int J Urol. 2008 Oct; 15(10):895-9.IJ

Abstract

OBJECTIVES

To investigate the association of lymphovascular invasion (LVI) in radical prostatectomy (RP) specimens with prostate-specific antigen (PSA) failure in patients with pT3aN0 prostate cancer (PCA).

METHODS

We retrospectively reviewed the clinical records of 94 patients with pT3aN0 PCA treated with RP alone. All of the 94 patients were prospectively observed without any treatment until PSA failure was confirmed. We investigated the association of LVI with the adverse pathological findings in RP specimens and the PSA failure-free survival rate. The Cox proportional hazard model was used to elucidate predictors of PSA failure.

RESULTS

Median follow up was 47.4 months (quartile range 9.1 to 146.8). LVI was found in 26 (27.7%) of the 94 patients. In a multivariate analysis, PSA (P = 0.0054) and LVI (P = 0.015) were significant and independent predictors of PSA failure. Stratifying patients into four risk groups by LVI status and PSA level, the PSA failure-free survival rate in patients with negative LVI and PSA < or =10 ng/mL was significantly better than any other groups (positive LVI and/or PSA >10 ng/mL).

CONCLUSIONS

Adjuvant therapy would not be indicated to patients with pT3aN0 PCA with negative LVI and PSA < or =10 ng/mL.

Authors+Show Affiliations

Department of Urology, Japanese Foundation for Cancer Research, Cancer Institute Hospital, Tokyo, Japan. yamamoto@jfcr.or.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18721204

Citation

Yamamoto, Shinya, et al. "Lymphovascular Invasion Is an Independent Predictor of Prostate-specific Antigen Failure After Radical Prostatectomy in Patients With pT3aN0 Prostate Cancer." International Journal of Urology : Official Journal of the Japanese Urological Association, vol. 15, no. 10, 2008, pp. 895-9.
Yamamoto S, Kawakami S, Yonese J, et al. Lymphovascular invasion is an independent predictor of prostate-specific antigen failure after radical prostatectomy in patients with pT3aN0 prostate cancer. Int J Urol. 2008;15(10):895-9.
Yamamoto, S., Kawakami, S., Yonese, J., Fujii, Y., Ohkubo, Y., Suyama, T., Komai, Y., Kijima, T., Ishikawa, Y., & Fukui, I. (2008). Lymphovascular invasion is an independent predictor of prostate-specific antigen failure after radical prostatectomy in patients with pT3aN0 prostate cancer. International Journal of Urology : Official Journal of the Japanese Urological Association, 15(10), 895-9. https://doi.org/10.1111/j.1442-2042.2008.02140.x
Yamamoto S, et al. Lymphovascular Invasion Is an Independent Predictor of Prostate-specific Antigen Failure After Radical Prostatectomy in Patients With pT3aN0 Prostate Cancer. Int J Urol. 2008;15(10):895-9. PubMed PMID: 18721204.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lymphovascular invasion is an independent predictor of prostate-specific antigen failure after radical prostatectomy in patients with pT3aN0 prostate cancer. AU - Yamamoto,Shinya, AU - Kawakami,Satoru, AU - Yonese,Junji, AU - Fujii,Yasuhisa, AU - Ohkubo,Yuhei, AU - Suyama,Taisuke, AU - Komai,Yoshinobu, AU - Kijima,Toshiki, AU - Ishikawa,Yuichi, AU - Fukui,Iwao, Y1 - 2008/08/20/ PY - 2008/8/30/pubmed PY - 2009/5/6/medline PY - 2008/8/30/entrez SP - 895 EP - 9 JF - International journal of urology : official journal of the Japanese Urological Association JO - Int J Urol VL - 15 IS - 10 N2 - OBJECTIVES: To investigate the association of lymphovascular invasion (LVI) in radical prostatectomy (RP) specimens with prostate-specific antigen (PSA) failure in patients with pT3aN0 prostate cancer (PCA). METHODS: We retrospectively reviewed the clinical records of 94 patients with pT3aN0 PCA treated with RP alone. All of the 94 patients were prospectively observed without any treatment until PSA failure was confirmed. We investigated the association of LVI with the adverse pathological findings in RP specimens and the PSA failure-free survival rate. The Cox proportional hazard model was used to elucidate predictors of PSA failure. RESULTS: Median follow up was 47.4 months (quartile range 9.1 to 146.8). LVI was found in 26 (27.7%) of the 94 patients. In a multivariate analysis, PSA (P = 0.0054) and LVI (P = 0.015) were significant and independent predictors of PSA failure. Stratifying patients into four risk groups by LVI status and PSA level, the PSA failure-free survival rate in patients with negative LVI and PSA < or =10 ng/mL was significantly better than any other groups (positive LVI and/or PSA >10 ng/mL). CONCLUSIONS: Adjuvant therapy would not be indicated to patients with pT3aN0 PCA with negative LVI and PSA < or =10 ng/mL. SN - 1442-2042 UR - https://www.unboundmedicine.com/medline/citation/18721204/Lymphovascular_invasion_is_an_independent_predictor_of_prostate_specific_antigen_failure_after_radical_prostatectomy_in_patients_with_pT3aN0_prostate_cancer_ L2 - https://doi.org/10.1111/j.1442-2042.2008.02140.x DB - PRIME DP - Unbound Medicine ER -