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Ejaculatory dysfunction caused by the new alpha1-blocker silodosin: A preliminary study to analyze human ejaculation using color Doppler ultrasonography.
Int J Urol. 2008 Oct; 15(10):915-918.IJ

Abstract

OBJECTIVES

In order to clinically investigate the mechanism of ejaculatory dysfunction attributable to the alpha1-blocker silodosin, a real-time observation of ejaculation by healthy males was performed.

METHODS

Following intake of silodosin, a newly developed selective alpha1-blocker for benign prostatic hypertrophy, ejaculation was dynamically observed using color Doppler ultrasound in three healthy males. Normal ejaculation was also investigated in the same manner.

RESULTS

With silodosin intake, no antegrade ejaculation was observed in cases 1 or 2. In case 1, seminal fluid slowly but continuously flowed out from the seminal vesicles into the bladder. In case 2, only a small amount of seminal fluid flowed into the bladder during the ejaculatory sensation. In case 3, ejection of a small amount of semen from the external urethral orifice was observed and inflow of a small amount of seminal fluid into the bladder was also captured. Without silodosin intake, all three subjects exhibited antegrade ejaculation.

CONCLUSIONS

The mechanism of ejaculatory dysfunction is intricately related to retrograde ejaculation (retrograde inflow of seminal fluid), insufficient contraction of the seminal vesicles, and insufficient rhythmic contraction of the muscles of the pelvic floor.

Authors+Show Affiliations

Department of Urology, Kawasaki Medical School, Kurashiki, Okayama, Japan. nagai@med.kawasaki-m.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18721206

Citation

Nagai, Atsushi, et al. "Ejaculatory Dysfunction Caused By the New Alpha1-blocker Silodosin: a Preliminary Study to Analyze Human Ejaculation Using Color Doppler Ultrasonography." International Journal of Urology : Official Journal of the Japanese Urological Association, vol. 15, no. 10, 2008, pp. 915-918.
Nagai A, Hara R, Yokoyama T, et al. Ejaculatory dysfunction caused by the new alpha1-blocker silodosin: A preliminary study to analyze human ejaculation using color Doppler ultrasonography. Int J Urol. 2008;15(10):915-918.
Nagai, A., Hara, R., Yokoyama, T., Jo, Y., Fujii, T., & Miyaji, Y. (2008). Ejaculatory dysfunction caused by the new alpha1-blocker silodosin: A preliminary study to analyze human ejaculation using color Doppler ultrasonography. International Journal of Urology : Official Journal of the Japanese Urological Association, 15(10), 915-918. https://doi.org/10.1111/j.1442-2042.2008.02136.x
Nagai A, et al. Ejaculatory Dysfunction Caused By the New Alpha1-blocker Silodosin: a Preliminary Study to Analyze Human Ejaculation Using Color Doppler Ultrasonography. Int J Urol. 2008;15(10):915-918. PubMed PMID: 18721206.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ejaculatory dysfunction caused by the new alpha1-blocker silodosin: A preliminary study to analyze human ejaculation using color Doppler ultrasonography. AU - Nagai,Atsushi, AU - Hara,Ryoei, AU - Yokoyama,Teruhiko, AU - Jo,Yoshimasa, AU - Fujii,Tomohiro, AU - Miyaji,Yoshiyuki, PY - 2008/8/30/pubmed PY - 2009/5/6/medline PY - 2008/8/30/entrez SP - 915 EP - 918 JF - International journal of urology : official journal of the Japanese Urological Association JO - Int J Urol VL - 15 IS - 10 N2 - OBJECTIVES: In order to clinically investigate the mechanism of ejaculatory dysfunction attributable to the alpha1-blocker silodosin, a real-time observation of ejaculation by healthy males was performed. METHODS: Following intake of silodosin, a newly developed selective alpha1-blocker for benign prostatic hypertrophy, ejaculation was dynamically observed using color Doppler ultrasound in three healthy males. Normal ejaculation was also investigated in the same manner. RESULTS: With silodosin intake, no antegrade ejaculation was observed in cases 1 or 2. In case 1, seminal fluid slowly but continuously flowed out from the seminal vesicles into the bladder. In case 2, only a small amount of seminal fluid flowed into the bladder during the ejaculatory sensation. In case 3, ejection of a small amount of semen from the external urethral orifice was observed and inflow of a small amount of seminal fluid into the bladder was also captured. Without silodosin intake, all three subjects exhibited antegrade ejaculation. CONCLUSIONS: The mechanism of ejaculatory dysfunction is intricately related to retrograde ejaculation (retrograde inflow of seminal fluid), insufficient contraction of the seminal vesicles, and insufficient rhythmic contraction of the muscles of the pelvic floor. SN - 1442-2042 UR - https://www.unboundmedicine.com/medline/citation/18721206/Ejaculatory_dysfunction_caused_by_the_new_alpha1_blocker_silodosin:_A_preliminary_study_to_analyze_human_ejaculation_using_color_Doppler_ultrasonography_ L2 - https://doi.org/10.1111/j.1442-2042.2008.02136.x DB - PRIME DP - Unbound Medicine ER -