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Cerebrospinal fluid levels of cytokines in non-herpetic acute limbic encephalitis: comparison with herpes simplex encephalitis.
Cytokine. 2008 Oct; 44(1):149-53.C

Abstract

BACKGROUND

Recently, non-herpetic acute limbic encephalitis (NHALE) was identified as a new subgroup of limbic encephalitis. The immunological pathophysiology of NHALE is still unclear.

METHODS

We measured the concentrations of interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2), IL-4, IL-6, IL-10, and soluble TNF receptor 1 (sTNFR1) in the cerebrospinal fluid (CSF) of 15 patients with NHALE and 13 with herpes simplex encephalitis (HSE) by cytometric bead array or ELISA.

RESULTS

The CSF concentrations of IL-6 in patients with NHALE and IFN-gamma, IL-6, IL-10, and sTNFR1 in HSE patients were significantly higher than those of controls (p<0.001, p=0.004, p<0.001, p=0.018, and p<0.001, respectively). There were significant correlations among CSF IL-6, IL-10, and sTNFR1 levels in HSE patients. The CSF concentrations of IFN-gamma and sTNFR1 levels of patients with HSE were significantly higher than those with NHALE (p=0.001 and p=0.002, respectively).

CONCLUSIONS

CSF cytokine levels in NHALE were relatively low compared with those in HSE. These results may be related to the favorable prognosis of NHALE.

Authors+Show Affiliations

Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan. ichiyama@yamaguchi-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18722137

Citation

Ichiyama, Takashi, et al. "Cerebrospinal Fluid Levels of Cytokines in Non-herpetic Acute Limbic Encephalitis: Comparison With Herpes Simplex Encephalitis." Cytokine, vol. 44, no. 1, 2008, pp. 149-53.
Ichiyama T, Shoji H, Takahashi Y, et al. Cerebrospinal fluid levels of cytokines in non-herpetic acute limbic encephalitis: comparison with herpes simplex encephalitis. Cytokine. 2008;44(1):149-53.
Ichiyama, T., Shoji, H., Takahashi, Y., Matsushige, T., Kajimoto, M., Inuzuka, T., & Furukawa, S. (2008). Cerebrospinal fluid levels of cytokines in non-herpetic acute limbic encephalitis: comparison with herpes simplex encephalitis. Cytokine, 44(1), 149-53. https://doi.org/10.1016/j.cyto.2008.07.002
Ichiyama T, et al. Cerebrospinal Fluid Levels of Cytokines in Non-herpetic Acute Limbic Encephalitis: Comparison With Herpes Simplex Encephalitis. Cytokine. 2008;44(1):149-53. PubMed PMID: 18722137.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cerebrospinal fluid levels of cytokines in non-herpetic acute limbic encephalitis: comparison with herpes simplex encephalitis. AU - Ichiyama,Takashi, AU - Shoji,Hiroshi, AU - Takahashi,Yukitoshi, AU - Matsushige,Takeshi, AU - Kajimoto,Madoka, AU - Inuzuka,Takashi, AU - Furukawa,Susumu, Y1 - 2008/08/21/ PY - 2008/05/26/received PY - 2008/06/20/revised PY - 2008/07/14/accepted PY - 2008/8/30/pubmed PY - 2009/1/24/medline PY - 2008/8/30/entrez SP - 149 EP - 53 JF - Cytokine JO - Cytokine VL - 44 IS - 1 N2 - BACKGROUND: Recently, non-herpetic acute limbic encephalitis (NHALE) was identified as a new subgroup of limbic encephalitis. The immunological pathophysiology of NHALE is still unclear. METHODS: We measured the concentrations of interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2), IL-4, IL-6, IL-10, and soluble TNF receptor 1 (sTNFR1) in the cerebrospinal fluid (CSF) of 15 patients with NHALE and 13 with herpes simplex encephalitis (HSE) by cytometric bead array or ELISA. RESULTS: The CSF concentrations of IL-6 in patients with NHALE and IFN-gamma, IL-6, IL-10, and sTNFR1 in HSE patients were significantly higher than those of controls (p<0.001, p=0.004, p<0.001, p=0.018, and p<0.001, respectively). There were significant correlations among CSF IL-6, IL-10, and sTNFR1 levels in HSE patients. The CSF concentrations of IFN-gamma and sTNFR1 levels of patients with HSE were significantly higher than those with NHALE (p=0.001 and p=0.002, respectively). CONCLUSIONS: CSF cytokine levels in NHALE were relatively low compared with those in HSE. These results may be related to the favorable prognosis of NHALE. SN - 1096-0023 UR - https://www.unboundmedicine.com/medline/citation/18722137/Cerebrospinal_fluid_levels_of_cytokines_in_non_herpetic_acute_limbic_encephalitis:_comparison_with_herpes_simplex_encephalitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1043-4666(08)00198-1 DB - PRIME DP - Unbound Medicine ER -