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Decline in influenza-associated mortality among Dutch elderly following the introduction of a nationwide vaccination program.
Vaccine. 2008 Oct 16; 26(44):5567-74.V

Abstract

With a retrospective nationwide cohort study in the Netherlands over 1992-2003, using mortality and viral surveillance data, the aim was to assess by means of rate difference methods the influenza-associated mortality in the elderly before and after the introduction of a nationwide influenza vaccination program in 1996 (vaccination coverage raised from below 50 to 80%). The average annual influenza-associated mortality declined in the years before and after the introduction from 131 to 105 per 100,000 persons (relative risk 0.80). The decline was largest in the age group 65-69 years (relative risk 0.54) and less in those aged 75 years and older. Validation by Serfling-type regression analysis revealed similar results. In conclusion, routine influenza vaccination among Dutch elderly was associated with a significant decrease in influenza-associated mortality, notably in those aged 65-69 years.

Authors+Show Affiliations

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18722492

Citation

Jansen, Angelique G S C., et al. "Decline in Influenza-associated Mortality Among Dutch Elderly Following the Introduction of a Nationwide Vaccination Program." Vaccine, vol. 26, no. 44, 2008, pp. 5567-74.
Jansen AG, Sanders EA, Nichol KL, et al. Decline in influenza-associated mortality among Dutch elderly following the introduction of a nationwide vaccination program. Vaccine. 2008;26(44):5567-74.
Jansen, A. G., Sanders, E. A., Nichol, K. L., van Loon, A. M., Hoes, A. W., & Hak, E. (2008). Decline in influenza-associated mortality among Dutch elderly following the introduction of a nationwide vaccination program. Vaccine, 26(44), 5567-74. https://doi.org/10.1016/j.vaccine.2008.08.003
Jansen AG, et al. Decline in Influenza-associated Mortality Among Dutch Elderly Following the Introduction of a Nationwide Vaccination Program. Vaccine. 2008 Oct 16;26(44):5567-74. PubMed PMID: 18722492.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decline in influenza-associated mortality among Dutch elderly following the introduction of a nationwide vaccination program. AU - Jansen,Angelique G S C, AU - Sanders,Elisabeth A M, AU - Nichol,Kristin L, AU - van Loon,Anton M, AU - Hoes,Arno W, AU - Hak,Eelko, Y1 - 2008/08/21/ PY - 2008/01/14/received PY - 2008/06/27/revised PY - 2008/08/04/accepted PY - 2008/8/30/pubmed PY - 2008/12/17/medline PY - 2008/8/30/entrez SP - 5567 EP - 74 JF - Vaccine JO - Vaccine VL - 26 IS - 44 N2 - With a retrospective nationwide cohort study in the Netherlands over 1992-2003, using mortality and viral surveillance data, the aim was to assess by means of rate difference methods the influenza-associated mortality in the elderly before and after the introduction of a nationwide influenza vaccination program in 1996 (vaccination coverage raised from below 50 to 80%). The average annual influenza-associated mortality declined in the years before and after the introduction from 131 to 105 per 100,000 persons (relative risk 0.80). The decline was largest in the age group 65-69 years (relative risk 0.54) and less in those aged 75 years and older. Validation by Serfling-type regression analysis revealed similar results. In conclusion, routine influenza vaccination among Dutch elderly was associated with a significant decrease in influenza-associated mortality, notably in those aged 65-69 years. SN - 0264-410X UR - https://www.unboundmedicine.com/medline/citation/18722492/Decline_in_influenza_associated_mortality_among_Dutch_elderly_following_the_introduction_of_a_nationwide_vaccination_program_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(08)01068-2 DB - PRIME DP - Unbound Medicine ER -