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Prognostic significance of cancer volume involving seminal vesicles in patients with pT3bpN0 prostate cancer.
Urology. 2008 Dec; 72(6):1224-8.U

Abstract

OBJECTIVES

To investigate the prognostic effect of the prostate cancer (PCa) volume involving the seminal vesicles (CVSVs) in the radical prostatectomy specimen from patients with Stage pT3bpN0 PCa.

METHODS

We retrospectively reviewed the clinical records of 27 patients with Stage pT3bpN0 PCa who had undergone radical prostatectomy alone. We measured the CVSVs using a grid method on the glass slide under microscopic inspection and investigated the association of the CVSVs with clinicopathologic variables.

RESULTS

Prostate-specific antigen (PSA) failure was confirmed in 11 of the 27 patients (41%) during a median follow-up of 34 months. The 3-year PSA failure-free survival rate was 48%. The median CVSVs was 1.14 cm(3). On univariate analysis, a CVSVs of >1.63 cm(3) was associated with positive surgical margins (P = .018), bilateral seminal vesicle involvement (P = .03), a long maximal tumor dimension (P = .031), and a greater preoperative PSA level (P = .0007). The 3-year PSA failure-free survival rate for those with a CVSVs of <or=1.63 cm(3) vs >1.63 cm(3) was 80% and 0%, respectively (P = .0009). On multivariate analysis, only the PSA level and CVSVs were identified as significant and independent predictors of PSA failure. Stratifying patients into 3 risk groups by these predictors, the PSA failure-free survival rate for patients with a PSA level >or=10 ng/mL and a CVSVs of >1.63 cm(3) was significantly worse than for any other group.

CONCLUSIONS

The CVSVs is useful and invaluable as an independent predictor of PSA failure in patients with Stage pT3bpN0 PCa. The measurement of the CVSVs is simple and helped to determine the indication for adjuvant treatment after radical prostatectomy.

Authors+Show Affiliations

Department of Urology, Japanese Foundation for Cancer Research, Cancer Institute Hospital, Tokyo, Japan. shinya.yamamoto@jfcr.or.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18723208

Citation

Yamamoto, Shinya, et al. "Prognostic Significance of Cancer Volume Involving Seminal Vesicles in Patients With pT3bpN0 Prostate Cancer." Urology, vol. 72, no. 6, 2008, pp. 1224-8.
Yamamoto S, Kawakami S, Yonese J, et al. Prognostic significance of cancer volume involving seminal vesicles in patients with pT3bpN0 prostate cancer. Urology. 2008;72(6):1224-8.
Yamamoto, S., Kawakami, S., Yonese, J., Fujii, Y., Tsukamoto, T., Ohkubo, Y., Komai, Y., Ishikawa, Y., & Fukui, I. (2008). Prognostic significance of cancer volume involving seminal vesicles in patients with pT3bpN0 prostate cancer. Urology, 72(6), 1224-8. https://doi.org/10.1016/j.urology.2008.06.055
Yamamoto S, et al. Prognostic Significance of Cancer Volume Involving Seminal Vesicles in Patients With pT3bpN0 Prostate Cancer. Urology. 2008;72(6):1224-8. PubMed PMID: 18723208.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prognostic significance of cancer volume involving seminal vesicles in patients with pT3bpN0 prostate cancer. AU - Yamamoto,Shinya, AU - Kawakami,Satoru, AU - Yonese,Junji, AU - Fujii,Yasuhisa, AU - Tsukamoto,Tetsuro, AU - Ohkubo,Yuhei, AU - Komai,Yoshinobu, AU - Ishikawa,Yuichi, AU - Fukui,Iwao, Y1 - 2008/08/23/ PY - 2008/04/01/received PY - 2008/06/15/revised PY - 2008/06/28/accepted PY - 2008/8/30/pubmed PY - 2009/1/7/medline PY - 2008/8/30/entrez SP - 1224 EP - 8 JF - Urology JO - Urology VL - 72 IS - 6 N2 - OBJECTIVES: To investigate the prognostic effect of the prostate cancer (PCa) volume involving the seminal vesicles (CVSVs) in the radical prostatectomy specimen from patients with Stage pT3bpN0 PCa. METHODS: We retrospectively reviewed the clinical records of 27 patients with Stage pT3bpN0 PCa who had undergone radical prostatectomy alone. We measured the CVSVs using a grid method on the glass slide under microscopic inspection and investigated the association of the CVSVs with clinicopathologic variables. RESULTS: Prostate-specific antigen (PSA) failure was confirmed in 11 of the 27 patients (41%) during a median follow-up of 34 months. The 3-year PSA failure-free survival rate was 48%. The median CVSVs was 1.14 cm(3). On univariate analysis, a CVSVs of >1.63 cm(3) was associated with positive surgical margins (P = .018), bilateral seminal vesicle involvement (P = .03), a long maximal tumor dimension (P = .031), and a greater preoperative PSA level (P = .0007). The 3-year PSA failure-free survival rate for those with a CVSVs of <or=1.63 cm(3) vs >1.63 cm(3) was 80% and 0%, respectively (P = .0009). On multivariate analysis, only the PSA level and CVSVs were identified as significant and independent predictors of PSA failure. Stratifying patients into 3 risk groups by these predictors, the PSA failure-free survival rate for patients with a PSA level >or=10 ng/mL and a CVSVs of >1.63 cm(3) was significantly worse than for any other group. CONCLUSIONS: The CVSVs is useful and invaluable as an independent predictor of PSA failure in patients with Stage pT3bpN0 PCa. The measurement of the CVSVs is simple and helped to determine the indication for adjuvant treatment after radical prostatectomy. SN - 1527-9995 UR - https://www.unboundmedicine.com/medline/citation/18723208/Prognostic_significance_of_cancer_volume_involving_seminal_vesicles_in_patients_with_pT3bpN0_prostate_cancer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-4295(08)00849-2 DB - PRIME DP - Unbound Medicine ER -