Tags

Type your tag names separated by a space and hit enter

Simultaneous isolation of six fluoroquinolones in serum samples by selective molecularly imprinted matrix solid-phase dispersion.
Anal Chim Acta. 2008 Sep 12; 625(2):154-9.AC

Abstract

A simple and sensitive method for the simultaneous determination of six fluoroquinolones from serum samples was developed by selective molecularly imprinted matrix solid-phase dispersion (MI-MSPD) coupled with chromatographic separation. By using ethylene glycol dimethacrylate as crosslinker and reformative methanol-water system as reaction medium, the improved water-compatible imprinted polymers were synthesized which show higher affinity to template and its analogues in aqueous environment. The molecularly imprinted polymers (MIPs) were applied as the selective dispersant of matrix solid-phase dispersion (MSPD) could selectively extracted the six fluoroquinolones from serum, while interferences originated from serum matrices were eliminated simultaneously. Good linearity was obtained in a range of 0.05-100 microg mL(-1) with the correlation coefficients >0.999. The average recoveries of the six fluoroquinolones at four different spiked levels (0.25-10 microg mL(-1)) were ranged from 72.2% to 114.1% with the relative standard deviations less than 6.6%. This method is simple and sensitive, and can be used as an alternative tool to the existing HPLC methods for analyzing the residues of fluoroquinolones in biological samples.

Links

Publisher Full Text

Authors+Show Affiliations

Sun H
College of Chemical and Environmental Sciences, Hebei University, Key Laboratory of Analytical Science and Technology of Hebei Province, Baoding, 071002, China.
Qiao F
No affiliation info available
Liu G
No affiliation info available
Liang S
No affiliation info available

MeSH

CalibrationChromatography, High Pressure LiquidFluoroquinolonesHumansLinear ModelsMolecular StructurePolymersReproducibility of ResultsSensitivity and SpecificitySolid Phase ExtractionTime Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18724989

Citation

Sun, Hanwen, et al. "Simultaneous Isolation of Six Fluoroquinolones in Serum Samples By Selective Molecularly Imprinted Matrix Solid-phase Dispersion." Analytica Chimica Acta, vol. 625, no. 2, 2008, pp. 154-9.
Sun H, Qiao F, Liu G, et al. Simultaneous isolation of six fluoroquinolones in serum samples by selective molecularly imprinted matrix solid-phase dispersion. Anal Chim Acta. 2008;625(2):154-9.
Sun, H., Qiao, F., Liu, G., & Liang, S. (2008). Simultaneous isolation of six fluoroquinolones in serum samples by selective molecularly imprinted matrix solid-phase dispersion. Analytica Chimica Acta, 625(2), 154-9. https://doi.org/10.1016/j.aca.2008.07.025
Sun H, et al. Simultaneous Isolation of Six Fluoroquinolones in Serum Samples By Selective Molecularly Imprinted Matrix Solid-phase Dispersion. Anal Chim Acta. 2008 Sep 12;625(2):154-9. PubMed PMID: 18724989.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simultaneous isolation of six fluoroquinolones in serum samples by selective molecularly imprinted matrix solid-phase dispersion. AU - Sun,Hanwen, AU - Qiao,Fengxia, AU - Liu,Guangyu, AU - Liang,Shuxuan, Y1 - 2008/07/25/ PY - 2008/03/15/received PY - 2008/07/16/revised PY - 2008/07/17/accepted PY - 2008/8/30/pubmed PY - 2008/10/9/medline PY - 2008/8/30/entrez SP - 154 EP - 9 JF - Analytica chimica acta JO - Anal Chim Acta VL - 625 IS - 2 N2 - A simple and sensitive method for the simultaneous determination of six fluoroquinolones from serum samples was developed by selective molecularly imprinted matrix solid-phase dispersion (MI-MSPD) coupled with chromatographic separation. By using ethylene glycol dimethacrylate as crosslinker and reformative methanol-water system as reaction medium, the improved water-compatible imprinted polymers were synthesized which show higher affinity to template and its analogues in aqueous environment. The molecularly imprinted polymers (MIPs) were applied as the selective dispersant of matrix solid-phase dispersion (MSPD) could selectively extracted the six fluoroquinolones from serum, while interferences originated from serum matrices were eliminated simultaneously. Good linearity was obtained in a range of 0.05-100 microg mL(-1) with the correlation coefficients >0.999. The average recoveries of the six fluoroquinolones at four different spiked levels (0.25-10 microg mL(-1)) were ranged from 72.2% to 114.1% with the relative standard deviations less than 6.6%. This method is simple and sensitive, and can be used as an alternative tool to the existing HPLC methods for analyzing the residues of fluoroquinolones in biological samples. SN - 1873-4324 UR - https://www.unboundmedicine.com/medline/citation/18724989/Simultaneous_isolation_of_six_fluoroquinolones_in_serum_samples_by_selective_molecularly_imprinted_matrix_solid_phase_dispersion_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-2670(08)01338-X DB - PRIME DP - Unbound Medicine ER -