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Interaction between serotonin 5-HT1A receptors and beta-endorphins modulates antidepressant response.
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Dec 12; 32(8):1804-9.PN

Abstract

Interactions between serotonergic and the endogenous opioid systems have been suggested to be involved in the etiopathogenesis of depression and in the mechanism of action of antidepressants. Activation of serotonin 5-HT1A receptors has been shown to increase plasma beta-endorphin (beta-END) levels in animal studies and in healthy humans.

OBJECTIVES

To assess interaction abnormalities between 5-HT1A receptors and the endogenous opioid system in patients with major depression and the possible modulating effect of citalopram.

METHODS

The beta-END response to the 5-HT1A receptor agonist, buspirone (30 mg), was measured in 30 patients with major depression and in 30 age- and sex-matched healthy controls before and after an 8-week treatment with citalopram. Pre-treatment score of the Hamilton Rating Scale for Depression (HRSD) was >or=17. Antidepressant response was defined by a 50% decrease in the HRSD. Pre- and post-treatment maximum peak response (Deltamax) and the area under the curve (AUC) of beta-END response were compared. Three time points were measured (60, 90 and 120 min). We also examined the correlations between the beta-END response and the antidepressant response. Buspirone plasma levels were not measured.

RESULTS

At baseline, beta-END response was similar in patients and controls. After 8 weeks of citalopram treatment depressed patients showed a significant decrease in the beta-END response (Deltamax: p<.001; AUC: p<.001). A significant correlation between the beta-END reduction in the response and the reduction in the HRSD score (r=.656; p<.001) was observed.

CONCLUSIONS

Changes in interaction between 5-HT1A receptor system and the endogenous opioid system may play a role both in the mechanism of action and response to antidepressant drugs.

Authors+Show Affiliations

Institut de Neurociències, Hospital Clínic, Universitat de Barcelona, IDIBAPS, Barcelona, Spain. rnavines@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18725263

Citation

Navinés, Ricard, et al. "Interaction Between Serotonin 5-HT1A Receptors and Beta-endorphins Modulates Antidepressant Response." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 32, no. 8, 2008, pp. 1804-9.
Navinés R, Martín-Santos R, Gómez-Gil E, et al. Interaction between serotonin 5-HT1A receptors and beta-endorphins modulates antidepressant response. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32(8):1804-9.
Navinés, R., Martín-Santos, R., Gómez-Gil, E., Martínez de Osaba, M. J., & Gastó, C. (2008). Interaction between serotonin 5-HT1A receptors and beta-endorphins modulates antidepressant response. Progress in Neuro-psychopharmacology & Biological Psychiatry, 32(8), 1804-9. https://doi.org/10.1016/j.pnpbp.2008.07.021
Navinés R, et al. Interaction Between Serotonin 5-HT1A Receptors and Beta-endorphins Modulates Antidepressant Response. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Dec 12;32(8):1804-9. PubMed PMID: 18725263.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interaction between serotonin 5-HT1A receptors and beta-endorphins modulates antidepressant response. AU - Navinés,Ricard, AU - Martín-Santos,Rocío, AU - Gómez-Gil,Esther, AU - Martínez de Osaba,María J, AU - Gastó,Cristòbal, Y1 - 2008/08/03/ PY - 2008/01/28/received PY - 2008/06/30/revised PY - 2008/07/30/accepted PY - 2008/8/30/pubmed PY - 2009/4/16/medline PY - 2008/8/30/entrez SP - 1804 EP - 9 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog Neuropsychopharmacol Biol Psychiatry VL - 32 IS - 8 N2 - UNLABELLED: Interactions between serotonergic and the endogenous opioid systems have been suggested to be involved in the etiopathogenesis of depression and in the mechanism of action of antidepressants. Activation of serotonin 5-HT1A receptors has been shown to increase plasma beta-endorphin (beta-END) levels in animal studies and in healthy humans. OBJECTIVES: To assess interaction abnormalities between 5-HT1A receptors and the endogenous opioid system in patients with major depression and the possible modulating effect of citalopram. METHODS: The beta-END response to the 5-HT1A receptor agonist, buspirone (30 mg), was measured in 30 patients with major depression and in 30 age- and sex-matched healthy controls before and after an 8-week treatment with citalopram. Pre-treatment score of the Hamilton Rating Scale for Depression (HRSD) was >or=17. Antidepressant response was defined by a 50% decrease in the HRSD. Pre- and post-treatment maximum peak response (Deltamax) and the area under the curve (AUC) of beta-END response were compared. Three time points were measured (60, 90 and 120 min). We also examined the correlations between the beta-END response and the antidepressant response. Buspirone plasma levels were not measured. RESULTS: At baseline, beta-END response was similar in patients and controls. After 8 weeks of citalopram treatment depressed patients showed a significant decrease in the beta-END response (Deltamax: p<.001; AUC: p<.001). A significant correlation between the beta-END reduction in the response and the reduction in the HRSD score (r=.656; p<.001) was observed. CONCLUSIONS: Changes in interaction between 5-HT1A receptor system and the endogenous opioid system may play a role both in the mechanism of action and response to antidepressant drugs. SN - 0278-5846 UR - https://www.unboundmedicine.com/medline/citation/18725263/Interaction_between_serotonin_5_HT1A_receptors_and_beta_endorphins_modulates_antidepressant_response_ DB - PRIME DP - Unbound Medicine ER -