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In vivo growth-inhibition of Sarcoma 180 by an alpha-(1-->4)-glucan-beta-(1-->6)-glucan-protein complex polysaccharide obtained from Agaricus blazei Murill.
J Nat Med. 2009 Jan; 63(1):32-40.JN

Abstract

Agaricus blazei Murrill, a native mushroom of Brazil, has been widely consumed in different parts of the world due to its anticancer potential. This effect is generally attributed to its polysaccharides; however, the precise structure of these has not been fully characterized. To better understand the relationship between polysaccharide structures and antitumor activity, we investigated the effect of the intraperitoneally (i.p.) or orally (p.o.) administered alpha-(1-->4)-glucan-beta-(1-->6)-glucan-protein complex polysaccharide from A. blazei alone or in association with 5-fluorouracil (5-FU) in tumor growth using Sarcoma 180 transplanted mice. Hematological, biochemical, and histopathological analyses were performed in order to evaluate the toxicological aspects of the polysaccharide treatment. The polysaccharide had no direct cytotoxic action on tumor cells in vitro. However, the polysaccharide showed strong in vivo antitumor effect. Thus, the tumor growth-inhibitory effect of the polysaccharide is apparently due to host-mediated mechanisms. The histopathological analysis suggests that the liver and the kidney were not affected by polysaccharide treatment. Neither enzymatic activity of transaminases (AST and ALT) nor urea levels were significantly altered. In hematological analysis, leucopeny was observed after 5-FU treatment, but this effect was prevented when the treatment was associated with the polysaccharide. In conclusion, this polysaccharide probably could explain the ethnopharmacological use of this mushroom in the treatment of cancer.

Authors+Show Affiliations

Department of Organic and Inorganic Chemistry, Federal University of Ceará, P.O. Box 12200, Fortaleza, Ceará, 60455-760, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18726068

Citation

Gonzaga, Maria Leônia Costa, et al. "In Vivo Growth-inhibition of Sarcoma 180 By an Alpha-(1-->4)-glucan-beta-(1-->6)-glucan-protein Complex Polysaccharide Obtained From Agaricus Blazei Murill." Journal of Natural Medicines, vol. 63, no. 1, 2009, pp. 32-40.
Gonzaga ML, Bezerra DP, Alves AP, et al. In vivo growth-inhibition of Sarcoma 180 by an alpha-(1-->4)-glucan-beta-(1-->6)-glucan-protein complex polysaccharide obtained from Agaricus blazei Murill. J Nat Med. 2009;63(1):32-40.
Gonzaga, M. L., Bezerra, D. P., Alves, A. P., de Alencar, N. M., Mesquita, R. d. e. . O., Lima, M. W., Soares, S. d. e. . A., Pessoa, C., de Moraes, M. O., & Costa-Lotufo, L. V. (2009). In vivo growth-inhibition of Sarcoma 180 by an alpha-(1-->4)-glucan-beta-(1-->6)-glucan-protein complex polysaccharide obtained from Agaricus blazei Murill. Journal of Natural Medicines, 63(1), 32-40. https://doi.org/10.1007/s11418-008-0286-4
Gonzaga ML, et al. In Vivo Growth-inhibition of Sarcoma 180 By an Alpha-(1-->4)-glucan-beta-(1-->6)-glucan-protein Complex Polysaccharide Obtained From Agaricus Blazei Murill. J Nat Med. 2009;63(1):32-40. PubMed PMID: 18726068.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vivo growth-inhibition of Sarcoma 180 by an alpha-(1-->4)-glucan-beta-(1-->6)-glucan-protein complex polysaccharide obtained from Agaricus blazei Murill. AU - Gonzaga,Maria Leônia Costa, AU - Bezerra,Daniel Pereira, AU - Alves,Ana Paula Negreiros Nunes, AU - de Alencar,Nylane Maria Nunes, AU - Mesquita,Rodney de Oliveira, AU - Lima,Michael Will, AU - Soares,Sandra de Aguiar, AU - Pessoa,Cláudia, AU - de Moraes,Manoel Odorico, AU - Costa-Lotufo,Letícia Veras, Y1 - 2008/08/23/ PY - 2008/03/19/received PY - 2008/07/25/accepted PY - 2008/8/30/pubmed PY - 2009/4/2/medline PY - 2008/8/30/entrez SP - 32 EP - 40 JF - Journal of natural medicines JO - J Nat Med VL - 63 IS - 1 N2 - Agaricus blazei Murrill, a native mushroom of Brazil, has been widely consumed in different parts of the world due to its anticancer potential. This effect is generally attributed to its polysaccharides; however, the precise structure of these has not been fully characterized. To better understand the relationship between polysaccharide structures and antitumor activity, we investigated the effect of the intraperitoneally (i.p.) or orally (p.o.) administered alpha-(1-->4)-glucan-beta-(1-->6)-glucan-protein complex polysaccharide from A. blazei alone or in association with 5-fluorouracil (5-FU) in tumor growth using Sarcoma 180 transplanted mice. Hematological, biochemical, and histopathological analyses were performed in order to evaluate the toxicological aspects of the polysaccharide treatment. The polysaccharide had no direct cytotoxic action on tumor cells in vitro. However, the polysaccharide showed strong in vivo antitumor effect. Thus, the tumor growth-inhibitory effect of the polysaccharide is apparently due to host-mediated mechanisms. The histopathological analysis suggests that the liver and the kidney were not affected by polysaccharide treatment. Neither enzymatic activity of transaminases (AST and ALT) nor urea levels were significantly altered. In hematological analysis, leucopeny was observed after 5-FU treatment, but this effect was prevented when the treatment was associated with the polysaccharide. In conclusion, this polysaccharide probably could explain the ethnopharmacological use of this mushroom in the treatment of cancer. SN - 1861-0293 UR - https://www.unboundmedicine.com/medline/citation/18726068/In_vivo_growth_inhibition_of_Sarcoma_180_by_an_alpha__1__>4__glucan_beta__1__>6__glucan_protein_complex_polysaccharide_obtained_from_Agaricus_blazei_Murill_ DB - PRIME DP - Unbound Medicine ER -