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The discovery of alpha-Klotho and FGF23 unveiled new insight into calcium and phosphate homeostasis.
Cell Mol Life Sci. 2008 Oct; 65(20):3218-30.CM

Abstract

1The traditional view of calcium homeostasis is that it is maintained by two essential reactions. First, changes in extracellular Ca2+ are sensed in several distinct cell types, stimulating the secretion of parathyroid hormone (PTH), 1,25(OH)(2) D and calcitonin in response to the body's requirement. Second, these calcitropic hormones then act on the calcium-translocating cells of the kidney, bone, and intestine to restore calcium balance. Recent progress indicates that alpha-Klotho and fibroblast growth factor (FGF) 23 are key players that integrate the multi-step regulatory system of calcium homeostasis that rapidly adjusts the extracellular calcium concentration and continuously maintains its concentration within a narrow physiological range. alpha-Klotho and FGF23 are also found to be major players in the regulatory system of phosphate homeostasis. Here, the demonstration of the molecular functions of alpha-Klotho and FGF23 has recently given new insight into the field of calcium and phosphate homeostasis.

Authors+Show Affiliations

Department of Pathology and Tumor Biology, Kyoto University Graduate School of Medicine, Yoshida Konoe-cho Sakyu-ku, Kyoto, 606 - 8501, Japan. nabemr@lmls.med.kyoto-u.ac.jp

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18726073

Citation

Nabeshima, Y. "The Discovery of alpha-Klotho and FGF23 Unveiled New Insight Into Calcium and Phosphate Homeostasis." Cellular and Molecular Life Sciences : CMLS, vol. 65, no. 20, 2008, pp. 3218-30.
Nabeshima Y. The discovery of alpha-Klotho and FGF23 unveiled new insight into calcium and phosphate homeostasis. Cell Mol Life Sci. 2008;65(20):3218-30.
Nabeshima, Y. (2008). The discovery of alpha-Klotho and FGF23 unveiled new insight into calcium and phosphate homeostasis. Cellular and Molecular Life Sciences : CMLS, 65(20), 3218-30. https://doi.org/10.1007/s00018-008-8177-0
Nabeshima Y. The Discovery of alpha-Klotho and FGF23 Unveiled New Insight Into Calcium and Phosphate Homeostasis. Cell Mol Life Sci. 2008;65(20):3218-30. PubMed PMID: 18726073.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The discovery of alpha-Klotho and FGF23 unveiled new insight into calcium and phosphate homeostasis. A1 - Nabeshima,Y, PY - 2008/8/30/pubmed PY - 2008/12/17/medline PY - 2008/8/30/entrez SP - 3218 EP - 30 JF - Cellular and molecular life sciences : CMLS JO - Cell Mol Life Sci VL - 65 IS - 20 N2 - 1The traditional view of calcium homeostasis is that it is maintained by two essential reactions. First, changes in extracellular Ca2+ are sensed in several distinct cell types, stimulating the secretion of parathyroid hormone (PTH), 1,25(OH)(2) D and calcitonin in response to the body's requirement. Second, these calcitropic hormones then act on the calcium-translocating cells of the kidney, bone, and intestine to restore calcium balance. Recent progress indicates that alpha-Klotho and fibroblast growth factor (FGF) 23 are key players that integrate the multi-step regulatory system of calcium homeostasis that rapidly adjusts the extracellular calcium concentration and continuously maintains its concentration within a narrow physiological range. alpha-Klotho and FGF23 are also found to be major players in the regulatory system of phosphate homeostasis. Here, the demonstration of the molecular functions of alpha-Klotho and FGF23 has recently given new insight into the field of calcium and phosphate homeostasis. SN - 1420-682X UR - https://www.unboundmedicine.com/medline/citation/18726073/The_discovery_of_alpha_Klotho_and_FGF23_unveiled_new_insight_into_calcium_and_phosphate_homeostasis_ L2 - https://doi.org/10.1007/s00018-008-8177-0 DB - PRIME DP - Unbound Medicine ER -