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[Melatonin expression in nasal polyps in patients with asthmatic triad].
Arkh Patol. 2008 May-Jun; 70(3):33-5.AP

Abstract

The expression of melatonin in nasal polyps versus the histological structure of tissue was studied in 11 patients with aspirin-induced asthma (AIA), 8 patients with asthma without aspirin intolerance, 13 patients with polypous rhinosinusopathy (PR) without bronchopulmonary diseases, and 10 apparently healthy individuals without nasal polyposis. The expression of melatonin in the nasal mucosa was found to be normal in healthy individuals. It significantly increased in polyp tissue in PR. The specific feature of polyp tissue in patients with aspirin triad was its high eosinophils levels that correlated with the increased area of melatonin expression. Thus, in AIA patients, the role of eosinophils increases in the production and/or delivery of the hormone into polyp tissue along with a drastic reduction in platelet melatonin generation. The findings explain persistent recurrent PR in AIA patients and an exacerbation of the disease after polyp removal.

Authors

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Pub Type(s)

English Abstract
Journal Article

Language

rus

PubMed ID

18727430

Citation

Evsiukova, E V., et al. "[Melatonin Expression in Nasal Polyps in Patients With Asthmatic Triad]." Arkhiv Patologii, vol. 70, no. 3, 2008, pp. 33-5.
Evsiukova EV, Okuneva EIu, Zubzhitskaia LB, et al. [Melatonin expression in nasal polyps in patients with asthmatic triad]. Arkh Patol. 2008;70(3):33-5.
Evsiukova, E. V., Okuneva, E. I. u., Zubzhitskaia, L. B., & Kvetnoĭ, I. M. (2008). [Melatonin expression in nasal polyps in patients with asthmatic triad]. Arkhiv Patologii, 70(3), 33-5.
Evsiukova EV, et al. [Melatonin Expression in Nasal Polyps in Patients With Asthmatic Triad]. Arkh Patol. 2008 May-Jun;70(3):33-5. PubMed PMID: 18727430.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Melatonin expression in nasal polyps in patients with asthmatic triad]. AU - Evsiukova,E V, AU - Okuneva,E Iu, AU - Zubzhitskaia,L B, AU - Kvetnoĭ,I M, PY - 2008/8/30/pubmed PY - 2008/9/24/medline PY - 2008/8/30/entrez SP - 33 EP - 5 JF - Arkhiv patologii JO - Arkh Patol VL - 70 IS - 3 N2 - The expression of melatonin in nasal polyps versus the histological structure of tissue was studied in 11 patients with aspirin-induced asthma (AIA), 8 patients with asthma without aspirin intolerance, 13 patients with polypous rhinosinusopathy (PR) without bronchopulmonary diseases, and 10 apparently healthy individuals without nasal polyposis. The expression of melatonin in the nasal mucosa was found to be normal in healthy individuals. It significantly increased in polyp tissue in PR. The specific feature of polyp tissue in patients with aspirin triad was its high eosinophils levels that correlated with the increased area of melatonin expression. Thus, in AIA patients, the role of eosinophils increases in the production and/or delivery of the hormone into polyp tissue along with a drastic reduction in platelet melatonin generation. The findings explain persistent recurrent PR in AIA patients and an exacerbation of the disease after polyp removal. SN - 0004-1955 UR - https://www.unboundmedicine.com/medline/citation/18727430/[Melatonin_expression_in_nasal_polyps_in_patients_with_asthmatic_triad]_ L2 - https://medlineplus.gov/asthma.html DB - PRIME DP - Unbound Medicine ER -