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Breastfeeding and prevalence of allergic diseases in Japanese university students.
Ann Allergy Asthma Immunol 2008; 101(2):153-9AA

Abstract

BACKGROUND

Although historical support exists for the concept that breastfeeding might be protective against allergic diseases, contradictory findings have been observed recently.

OBJECTIVE

To investigate the cumulative prevalence of allergic diseases in Japanese university students and to identify explanatory variables including breastfeeding.

METHODS

From March 18, 2003, through March 29, 2005, a total of 9,615 students newly enrolled at the University of Tokyo responded to a written questionnaire on allergic diseases.

RESULTS

Cumulative prevalence of allergic rhinitis, atopic dermatitis, and asthma was 47.2%, 17.4%, and 9.3%, respectively. These data were closely correlated, and prevalence of any 1 of the 3 diseases significantly increased the odds for historical prevalence of the other 2 (P < .001). Male sex (odds ratio [OR], 1.5; 95% confidence interval [CI], 1.4-1.7) and maternal (OR, 2.2; 95% CI, 2.0-2.5) or paternal (OR, 1.6; 95% CI, 1.4-1.8) history of allergic rhinitis were significant correlates of increased odds for allergic rhinitis. Maternal (OR, 2.7; 95% CI, 1.6-4.5), paternal (OR, 3.8; 95% CI, 2.2-6.6), or sibling (OR, 1.9; 95% CI, 1.5-2.4) history of atopic dermatitis was a significant correlate of increased odds for atopic dermatitis. As for asthma, maternal (OR, 4.9; 95% CI, 3.0-7.9), paternal (OR, 4.0; 95% CI, 2.3-7.0), or sibling (OR, 3.3; 95% CI, 2.4-4.5) history of asthma was a significant correlate of increased odds. Logistic regression analysis showed no consistent evidence of the effects of breastfeeding on the cumulative prevalence.

CONCLUSION

The cumulative prevalence of these diseases among young adults revealed that the effect of breastfeeding is negligible when compared with genetic factors.

Authors+Show Affiliations

Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine, Health Service Centre, University of Tokyo, Tokyo, Japan. karinos-tky@umin.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18727470

Citation

Karino, Shotaro, et al. "Breastfeeding and Prevalence of Allergic Diseases in Japanese University Students." Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, vol. 101, no. 2, 2008, pp. 153-9.
Karino S, Okuda T, Uehara Y, et al. Breastfeeding and prevalence of allergic diseases in Japanese university students. Ann Allergy Asthma Immunol. 2008;101(2):153-9.
Karino, S., Okuda, T., Uehara, Y., & Toyo-oka, T. (2008). Breastfeeding and prevalence of allergic diseases in Japanese university students. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 101(2), pp. 153-9. doi:10.1016/S1081-1206(10)60203-7.
Karino S, et al. Breastfeeding and Prevalence of Allergic Diseases in Japanese University Students. Ann Allergy Asthma Immunol. 2008;101(2):153-9. PubMed PMID: 18727470.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Breastfeeding and prevalence of allergic diseases in Japanese university students. AU - Karino,Shotaro, AU - Okuda,Toshihiro, AU - Uehara,Yoshio, AU - Toyo-oka,Teruhiko, PY - 2008/8/30/pubmed PY - 2008/9/23/medline PY - 2008/8/30/entrez SP - 153 EP - 9 JF - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JO - Ann. Allergy Asthma Immunol. VL - 101 IS - 2 N2 - BACKGROUND: Although historical support exists for the concept that breastfeeding might be protective against allergic diseases, contradictory findings have been observed recently. OBJECTIVE: To investigate the cumulative prevalence of allergic diseases in Japanese university students and to identify explanatory variables including breastfeeding. METHODS: From March 18, 2003, through March 29, 2005, a total of 9,615 students newly enrolled at the University of Tokyo responded to a written questionnaire on allergic diseases. RESULTS: Cumulative prevalence of allergic rhinitis, atopic dermatitis, and asthma was 47.2%, 17.4%, and 9.3%, respectively. These data were closely correlated, and prevalence of any 1 of the 3 diseases significantly increased the odds for historical prevalence of the other 2 (P < .001). Male sex (odds ratio [OR], 1.5; 95% confidence interval [CI], 1.4-1.7) and maternal (OR, 2.2; 95% CI, 2.0-2.5) or paternal (OR, 1.6; 95% CI, 1.4-1.8) history of allergic rhinitis were significant correlates of increased odds for allergic rhinitis. Maternal (OR, 2.7; 95% CI, 1.6-4.5), paternal (OR, 3.8; 95% CI, 2.2-6.6), or sibling (OR, 1.9; 95% CI, 1.5-2.4) history of atopic dermatitis was a significant correlate of increased odds for atopic dermatitis. As for asthma, maternal (OR, 4.9; 95% CI, 3.0-7.9), paternal (OR, 4.0; 95% CI, 2.3-7.0), or sibling (OR, 3.3; 95% CI, 2.4-4.5) history of asthma was a significant correlate of increased odds. Logistic regression analysis showed no consistent evidence of the effects of breastfeeding on the cumulative prevalence. CONCLUSION: The cumulative prevalence of these diseases among young adults revealed that the effect of breastfeeding is negligible when compared with genetic factors. SN - 1081-1206 UR - https://www.unboundmedicine.com/medline/citation/18727470/Breastfeeding_and_prevalence_of_allergic_diseases_in_Japanese_university_students_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1081-1206(10)60203-7 DB - PRIME DP - Unbound Medicine ER -