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Allergy to kiwi in patients with baker's asthma: identification of potential cross-reactive allergens.
Ann Allergy Asthma Immunol 2008; 101(2):200-5AA

Abstract

BACKGROUND

Baker's asthma is a frequent IgE-mediated occupational disorder mainly provoked by inhalation of cereal flour. Allergy to kiwifruit has being increasingly reported in the past few years. No association between both allergic disorders has been described so far.

METHODS

Twenty patients with occupational asthma caused by wheat flour inhalation were studied. Kiwi allergens Act d 1 and Act d 2 were purified by cation-exchange chromatography. Wheat, rye, and kiwi extracts, purified kiwi allergens, and model plant glycoproteins were analyzed by IgE immunodetection, enzyme-linked immunosorbent assay (ELISA), and inhibition ELISAs.

RESULTS

Kiwifruit ingestion elicited oral allergy syndrome in 7 of the 20 patients (35%) with baker's asthma. Positive specific IgE and skin prick test responses to this fruit were found in all these kiwi allergic patients, and IgE to Act d 1 and Act d 2 was detected in 57% and 43%, respectively, of the corresponding sera. Actinidin Act d 1 and bromelain (harboring cross-reactive carbohydrate determinants) reached above 50% inhibition of the IgE binding to wheat and/or kiwi extracts.

CONCLUSIONS

A potential association between respiratory allergy to cereal flour and allergy to kiwifruit has been disclosed. Cross-reactive carbohydrate determinants and thiol-proteaseshomologous to Act d 1 are responsible for wheat-kiwi crossreactivity in some patients.

Authors+Show Affiliations

Unidad de Bioquímica, Departamento de Biotecnología, E.T.S. Ingenieros Agrónomos, UPM, Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18727477

Citation

Palacin, Arantxa, et al. "Allergy to Kiwi in Patients With Baker's Asthma: Identification of Potential Cross-reactive Allergens." Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, vol. 101, no. 2, 2008, pp. 200-5.
Palacin A, Quirce S, Sánchez-Monge R, et al. Allergy to kiwi in patients with baker's asthma: identification of potential cross-reactive allergens. Ann Allergy Asthma Immunol. 2008;101(2):200-5.
Palacin, A., Quirce, S., Sánchez-Monge, R., Fernández-Nieto, M., Varela, J., Sastre, J., & Salcedo, G. (2008). Allergy to kiwi in patients with baker's asthma: identification of potential cross-reactive allergens. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 101(2), pp. 200-5. doi:10.1016/S1081-1206(10)60210-4.
Palacin A, et al. Allergy to Kiwi in Patients With Baker's Asthma: Identification of Potential Cross-reactive Allergens. Ann Allergy Asthma Immunol. 2008;101(2):200-5. PubMed PMID: 18727477.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Allergy to kiwi in patients with baker's asthma: identification of potential cross-reactive allergens. AU - Palacin,Arantxa, AU - Quirce,Santiago, AU - Sánchez-Monge,Rosa, AU - Fernández-Nieto,Mar, AU - Varela,Javier, AU - Sastre,Joaquín, AU - Salcedo,Gabriel, PY - 2008/8/30/pubmed PY - 2008/9/23/medline PY - 2008/8/30/entrez SP - 200 EP - 5 JF - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JO - Ann. Allergy Asthma Immunol. VL - 101 IS - 2 N2 - BACKGROUND: Baker's asthma is a frequent IgE-mediated occupational disorder mainly provoked by inhalation of cereal flour. Allergy to kiwifruit has being increasingly reported in the past few years. No association between both allergic disorders has been described so far. METHODS: Twenty patients with occupational asthma caused by wheat flour inhalation were studied. Kiwi allergens Act d 1 and Act d 2 were purified by cation-exchange chromatography. Wheat, rye, and kiwi extracts, purified kiwi allergens, and model plant glycoproteins were analyzed by IgE immunodetection, enzyme-linked immunosorbent assay (ELISA), and inhibition ELISAs. RESULTS: Kiwifruit ingestion elicited oral allergy syndrome in 7 of the 20 patients (35%) with baker's asthma. Positive specific IgE and skin prick test responses to this fruit were found in all these kiwi allergic patients, and IgE to Act d 1 and Act d 2 was detected in 57% and 43%, respectively, of the corresponding sera. Actinidin Act d 1 and bromelain (harboring cross-reactive carbohydrate determinants) reached above 50% inhibition of the IgE binding to wheat and/or kiwi extracts. CONCLUSIONS: A potential association between respiratory allergy to cereal flour and allergy to kiwifruit has been disclosed. Cross-reactive carbohydrate determinants and thiol-proteaseshomologous to Act d 1 are responsible for wheat-kiwi crossreactivity in some patients. SN - 1081-1206 UR - https://www.unboundmedicine.com/medline/citation/18727477/Allergy_to_kiwi_in_patients_with_baker's_asthma:_identification_of_potential_cross_reactive_allergens_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1081-1206(10)60210-4 DB - PRIME DP - Unbound Medicine ER -