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The antiemetic interaction of Delta9-tetrahydrocannabinol when combined with tropisetron or dexamethasone in the least shrew.
Pharmacol Biochem Behav 2009; 91(3):367-73PB

Abstract

5-HT3 receptor antagonists (e.g. tropisetron) combined with dexamethasone are effective for the acute phase of cisplatin (CIS)-induced emesis. This study determined the possible additive or synergistic antiemetic efficacy of Delta9-THC when combined with tropisetron or dexamethasone (DEX). Delta9-THC (0-10 mg/kg i.p.) was injected in combination with tropisetron (0-5 mg/kg i.p.) or dexamethasone (0-20 mg/kg i.p.) prior to CIS (20 mg/kg i.p.) in the least shrew, and the induced emesis was recorded for 60 min. CIS-induced vomiting was dose-dependently and significantly attenuated by individual administration of Delta9-THC (59-97% reductions) and tropisetron (79-100% attenuation), but not dexamethasone (26-40%), although a trend (p<0.1) towards reduced vomiting frequency following DEX was noted. Low doses of Delta9-THC (0.25 or 0.5 mg/kg) when combined with low doses of tropisetron (0.025, 0.1, or 0.25 mg/kg) were more efficacious in reducing emesis frequency than when given individually, but Delta9-THC had no antiemetic interactions with DEX. However, no tested combination provided a significantly greater effect on the number of animals vomiting than their individually-administered counterparts. The modest interaction of Delta9-THC with tropisetron suggests they activate overlapping antiemetic mechanisms, while the lack of interaction with dexamethasone needs further clarification.

Authors+Show Affiliations

Department of Basic Medical Sciences, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766-1854, United States.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18727934

Citation

Wang, Yaozhi, et al. "The Antiemetic Interaction of Delta9-tetrahydrocannabinol when Combined With Tropisetron or Dexamethasone in the Least Shrew." Pharmacology, Biochemistry, and Behavior, vol. 91, no. 3, 2009, pp. 367-73.
Wang Y, Ray AP, McClanahan BA, et al. The antiemetic interaction of Delta9-tetrahydrocannabinol when combined with tropisetron or dexamethasone in the least shrew. Pharmacol Biochem Behav. 2009;91(3):367-73.
Wang, Y., Ray, A. P., McClanahan, B. A., & Darmani, N. A. (2009). The antiemetic interaction of Delta9-tetrahydrocannabinol when combined with tropisetron or dexamethasone in the least shrew. Pharmacology, Biochemistry, and Behavior, 91(3), pp. 367-73. doi:10.1016/j.pbb.2008.08.008.
Wang Y, et al. The Antiemetic Interaction of Delta9-tetrahydrocannabinol when Combined With Tropisetron or Dexamethasone in the Least Shrew. Pharmacol Biochem Behav. 2009;91(3):367-73. PubMed PMID: 18727934.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The antiemetic interaction of Delta9-tetrahydrocannabinol when combined with tropisetron or dexamethasone in the least shrew. AU - Wang,Yaozhi, AU - Ray,Andrew P, AU - McClanahan,Bryan A, AU - Darmani,Nissar A, Y1 - 2008/08/09/ PY - 2008/05/14/received PY - 2008/08/05/revised PY - 2008/08/05/accepted PY - 2008/8/30/pubmed PY - 2009/4/3/medline PY - 2008/8/30/entrez SP - 367 EP - 73 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol. Biochem. Behav. VL - 91 IS - 3 N2 - 5-HT3 receptor antagonists (e.g. tropisetron) combined with dexamethasone are effective for the acute phase of cisplatin (CIS)-induced emesis. This study determined the possible additive or synergistic antiemetic efficacy of Delta9-THC when combined with tropisetron or dexamethasone (DEX). Delta9-THC (0-10 mg/kg i.p.) was injected in combination with tropisetron (0-5 mg/kg i.p.) or dexamethasone (0-20 mg/kg i.p.) prior to CIS (20 mg/kg i.p.) in the least shrew, and the induced emesis was recorded for 60 min. CIS-induced vomiting was dose-dependently and significantly attenuated by individual administration of Delta9-THC (59-97% reductions) and tropisetron (79-100% attenuation), but not dexamethasone (26-40%), although a trend (p<0.1) towards reduced vomiting frequency following DEX was noted. Low doses of Delta9-THC (0.25 or 0.5 mg/kg) when combined with low doses of tropisetron (0.025, 0.1, or 0.25 mg/kg) were more efficacious in reducing emesis frequency than when given individually, but Delta9-THC had no antiemetic interactions with DEX. However, no tested combination provided a significantly greater effect on the number of animals vomiting than their individually-administered counterparts. The modest interaction of Delta9-THC with tropisetron suggests they activate overlapping antiemetic mechanisms, while the lack of interaction with dexamethasone needs further clarification. SN - 0091-3057 UR - https://www.unboundmedicine.com/medline/citation/18727934/The_antiemetic_interaction_of_Delta9_tetrahydrocannabinol_when_combined_with_tropisetron_or_dexamethasone_in_the_least_shrew_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(08)00282-7 DB - PRIME DP - Unbound Medicine ER -