TY - JOUR T1 - Analgesic and anti-inflammatory effects of Ligularia fischeri leaves in experimental animals. AU - Lee,Kyung-Hee, AU - Choi,Eun-Mi, Y1 - 2008/08/05/ PY - 2008/01/02/received PY - 2008/07/27/revised PY - 2008/07/28/accepted PY - 2008/8/30/pubmed PY - 2009/1/28/medline PY - 2008/8/30/entrez SP - 103 EP - 7 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 120 IS - 1 N2 - AIM OF THE STUDY: The ethanol extract (LF) of Ligularia fischeri var. spiciformis (leaf) has been evaluated for antinociceptive and anti-inflammatory activities in mice. MATERIALS AND METHODS: Analgesic and anti-inflammatory activities were studied by measuring nociception induced by formalin, acetic acid and hot-plate, and inflammation induced by carrageenan, formalin, and arachidonic acid. RESULTS: The acute treatment of mice with LF at doses of 100 and 200mg/kg, by oral administration, produced a significant antinociceptive effect in the acetic acid-induced writhing, formalin-induced pain licking and hot-plate-induced pain. Also, the LF significantly inhibited both carrageenan- and formalin-induced inflammation as well as arachidonic acid-induced ear edema in mice. CONCLUSIONS: These inhibitions were statistically significant (P<0.05). Thus, our investigation suggests a potential benefit of Ligularia fischeri in treating conditions associated with inflammatory pain. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/18727955/Analgesic_and_anti_inflammatory_effects_of_Ligularia_fischeri_leaves_in_experimental_animals_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(08)00419-4 DB - PRIME DP - Unbound Medicine ER -