Abstract
AIM OF THE STUDY
The ethanol extract (LF) of Ligularia fischeri var. spiciformis (leaf) has been evaluated for antinociceptive and anti-inflammatory activities in mice.
MATERIALS AND METHODS
Analgesic and anti-inflammatory activities were studied by measuring nociception induced by formalin, acetic acid and hot-plate, and inflammation induced by carrageenan, formalin, and arachidonic acid.
RESULTS
The acute treatment of mice with LF at doses of 100 and 200mg/kg, by oral administration, produced a significant antinociceptive effect in the acetic acid-induced writhing, formalin-induced pain licking and hot-plate-induced pain. Also, the LF significantly inhibited both carrageenan- and formalin-induced inflammation as well as arachidonic acid-induced ear edema in mice.
CONCLUSIONS
These inhibitions were statistically significant (P<0.05). Thus, our investigation suggests a potential benefit of Ligularia fischeri in treating conditions associated with inflammatory pain.
TY - JOUR
T1 - Analgesic and anti-inflammatory effects of Ligularia fischeri leaves in experimental animals.
AU - Lee,Kyung-Hee,
AU - Choi,Eun-Mi,
Y1 - 2008/08/05/
PY - 2008/01/02/received
PY - 2008/07/27/revised
PY - 2008/07/28/accepted
PY - 2008/8/30/pubmed
PY - 2009/1/28/medline
PY - 2008/8/30/entrez
SP - 103
EP - 7
JF - Journal of ethnopharmacology
JO - J Ethnopharmacol
VL - 120
IS - 1
N2 - AIM OF THE STUDY: The ethanol extract (LF) of Ligularia fischeri var. spiciformis (leaf) has been evaluated for antinociceptive and anti-inflammatory activities in mice. MATERIALS AND METHODS: Analgesic and anti-inflammatory activities were studied by measuring nociception induced by formalin, acetic acid and hot-plate, and inflammation induced by carrageenan, formalin, and arachidonic acid. RESULTS: The acute treatment of mice with LF at doses of 100 and 200mg/kg, by oral administration, produced a significant antinociceptive effect in the acetic acid-induced writhing, formalin-induced pain licking and hot-plate-induced pain. Also, the LF significantly inhibited both carrageenan- and formalin-induced inflammation as well as arachidonic acid-induced ear edema in mice. CONCLUSIONS: These inhibitions were statistically significant (P<0.05). Thus, our investigation suggests a potential benefit of Ligularia fischeri in treating conditions associated with inflammatory pain.
SN - 0378-8741
UR - https://www.unboundmedicine.com/medline/citation/18727955/Analgesic_and_anti_inflammatory_effects_of_Ligularia_fischeri_leaves_in_experimental_animals_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(08)00419-4
DB - PRIME
DP - Unbound Medicine
ER -