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Analgesic and anti-inflammatory effects of Ligularia fischeri leaves in experimental animals.
J Ethnopharmacol. 2008 Oct 30; 120(1):103-7.JE

Abstract

AIM OF THE STUDY

The ethanol extract (LF) of Ligularia fischeri var. spiciformis (leaf) has been evaluated for antinociceptive and anti-inflammatory activities in mice.

MATERIALS AND METHODS

Analgesic and anti-inflammatory activities were studied by measuring nociception induced by formalin, acetic acid and hot-plate, and inflammation induced by carrageenan, formalin, and arachidonic acid.

RESULTS

The acute treatment of mice with LF at doses of 100 and 200mg/kg, by oral administration, produced a significant antinociceptive effect in the acetic acid-induced writhing, formalin-induced pain licking and hot-plate-induced pain. Also, the LF significantly inhibited both carrageenan- and formalin-induced inflammation as well as arachidonic acid-induced ear edema in mice.

CONCLUSIONS

These inhibitions were statistically significant (P<0.05). Thus, our investigation suggests a potential benefit of Ligularia fischeri in treating conditions associated with inflammatory pain.

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  • Publisher Full Text

    • Authors+Show Affiliations

    Lee KH
    Department of Food Service Management, College of Hotel and Tourism Management, Kyung Hee University, Seoul 130-701, Republic of Korea.
    Choi EM
    No affiliation info available

    MeSH

    Administration, OralAnalgesicsAnimalsAnti-Inflammatory AgentsAsteraceaeDose-Response Relationship, DrugEdemaInflammationMaleMiceMice, Inbred ICRPainPain MeasurementPlant ExtractsPlant Leaves

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    18727955

    Citation

    Lee, Kyung-Hee, and Eun-Mi Choi. "Analgesic and Anti-inflammatory Effects of Ligularia Fischeri Leaves in Experimental Animals." Journal of Ethnopharmacology, vol. 120, no. 1, 2008, pp. 103-7.
    Lee KH, Choi EM. Analgesic and anti-inflammatory effects of Ligularia fischeri leaves in experimental animals. J Ethnopharmacol. 2008;120(1):103-7.
    Lee, K. H., & Choi, E. M. (2008). Analgesic and anti-inflammatory effects of Ligularia fischeri leaves in experimental animals. Journal of Ethnopharmacology, 120(1), 103-7. https://doi.org/10.1016/j.jep.2008.07.038
    Lee KH, Choi EM. Analgesic and Anti-inflammatory Effects of Ligularia Fischeri Leaves in Experimental Animals. J Ethnopharmacol. 2008 Oct 30;120(1):103-7. PubMed PMID: 18727955.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Analgesic and anti-inflammatory effects of Ligularia fischeri leaves in experimental animals. AU - Lee,Kyung-Hee, AU - Choi,Eun-Mi, Y1 - 2008/08/05/ PY - 2008/01/02/received PY - 2008/07/27/revised PY - 2008/07/28/accepted PY - 2008/8/30/pubmed PY - 2009/1/28/medline PY - 2008/8/30/entrez SP - 103 EP - 7 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 120 IS - 1 N2 - AIM OF THE STUDY: The ethanol extract (LF) of Ligularia fischeri var. spiciformis (leaf) has been evaluated for antinociceptive and anti-inflammatory activities in mice. MATERIALS AND METHODS: Analgesic and anti-inflammatory activities were studied by measuring nociception induced by formalin, acetic acid and hot-plate, and inflammation induced by carrageenan, formalin, and arachidonic acid. RESULTS: The acute treatment of mice with LF at doses of 100 and 200mg/kg, by oral administration, produced a significant antinociceptive effect in the acetic acid-induced writhing, formalin-induced pain licking and hot-plate-induced pain. Also, the LF significantly inhibited both carrageenan- and formalin-induced inflammation as well as arachidonic acid-induced ear edema in mice. CONCLUSIONS: These inhibitions were statistically significant (P<0.05). Thus, our investigation suggests a potential benefit of Ligularia fischeri in treating conditions associated with inflammatory pain. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/18727955/Analgesic_and_anti_inflammatory_effects_of_Ligularia_fischeri_leaves_in_experimental_animals_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(08)00419-4 DB - PRIME DP - Unbound Medicine ER -