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Immunoglobulin A anti-tissue transglutaminase antibody deposits in the small intestinal mucosa of children with no villous atrophy.
J Pediatr Gastroenterol Nutr. 2008 Sep; 47(3):293-8.JP

Abstract

OBJECTIVES

Anti-tissue transglutaminase (anti-TG2) immunoglobulin A (IgA) autoantibodies are detectable in the serum of most patients with untreated celiac disease (CD). Their deposits in the intestine of patients with CD with severe enteropathy are considered specific for this condition. The histological spectrum of CD includes cases with normal villous architecture. The aim of this study was to look for anti-TG2 IgA deposits in the intestine of children with normal villous architecture and to relate them with other markers of gluten sensitivity.

PATIENTS AND METHODS

A total of 57 children with normal duodenal villous architecture and markers of gluten sensitivity were considered. Of those, 39 showed positive serum anti-endomysium antibodies and/or high levels of anti-TG2 antibodies (group 1), and 18 were seronegative with only a greater density of gammadelta intraepithelial lymphocytes (group 2). Thirty-four children with no markers of gluten sensitivity and a normal mucosa represented the control group (group 3). The duodenal sections of all patients were investigated for deposited anti-TG2 IgA by double immunofluorescence. Human lymphocyte antigen molecular typing was performed.

RESULTS

In group 1 and in group 2, 33 of 39 children (85%) and 12 of 18 children (66%) showed subepithelial anti-TG2 IgA intestinal deposits, respectively. Only in 3 of 34 (8.8%) children with no markers of gluten sensitivity were anti-TG2 IgA deposits noted.

CONCLUSIONS

A subgroup of children with no serum CD-associated autoantibodies, but greater density of gammadelta intraepithelial lymphocytes, shows a clear anti-TG2 IgA deposition in the duodenal mucosa. These children must be investigated further for possible gluten sensitivity.

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Authors+Show Affiliations

Tosco A
Department of Pediatrics and European Laboratory for the Investigation of Food-Induced Diseases, University Federico II, Naples, Italy.
Maglio M
No affiliation info available
Paparo F
No affiliation info available
Rapacciuolo L
No affiliation info available
Sannino A
No affiliation info available
Miele E
No affiliation info available
Barone MV
No affiliation info available
Auricchio R
No affiliation info available
Troncone R
No affiliation info available

MeSH

AdolescentAntibody SpecificityAutoantibodiesBiomarkersCeliac DiseaseChildChild, PreschoolFemaleGlutensHumansImmunoglobulin AInfantIntestinal MucosaIntestine, SmallMaleTransglutaminases

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18728524

Citation

Tosco, Antonella, et al. "Immunoglobulin a Anti-tissue Transglutaminase Antibody Deposits in the Small Intestinal Mucosa of Children With No Villous Atrophy." Journal of Pediatric Gastroenterology and Nutrition, vol. 47, no. 3, 2008, pp. 293-8.
Tosco A, Maglio M, Paparo F, et al. Immunoglobulin A anti-tissue transglutaminase antibody deposits in the small intestinal mucosa of children with no villous atrophy. J Pediatr Gastroenterol Nutr. 2008;47(3):293-8.
Tosco, A., Maglio, M., Paparo, F., Rapacciuolo, L., Sannino, A., Miele, E., Barone, M. V., Auricchio, R., & Troncone, R. (2008). Immunoglobulin A anti-tissue transglutaminase antibody deposits in the small intestinal mucosa of children with no villous atrophy. Journal of Pediatric Gastroenterology and Nutrition, 47(3), 293-8. https://doi.org/10.1097/MPG.0b013e3181677067
Tosco A, et al. Immunoglobulin a Anti-tissue Transglutaminase Antibody Deposits in the Small Intestinal Mucosa of Children With No Villous Atrophy. J Pediatr Gastroenterol Nutr. 2008;47(3):293-8. PubMed PMID: 18728524.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunoglobulin A anti-tissue transglutaminase antibody deposits in the small intestinal mucosa of children with no villous atrophy. AU - Tosco,Antonella, AU - Maglio,Maria, AU - Paparo,Francesco, AU - Rapacciuolo,Luciano, AU - Sannino,Anna, AU - Miele,Erasmo, AU - Barone,Maria Vittoria, AU - Auricchio,Renata, AU - Troncone,Riccardo, PY - 2008/8/30/pubmed PY - 2008/12/19/medline PY - 2008/8/30/entrez SP - 293 EP - 8 JF - Journal of pediatric gastroenterology and nutrition JO - J Pediatr Gastroenterol Nutr VL - 47 IS - 3 N2 - OBJECTIVES: Anti-tissue transglutaminase (anti-TG2) immunoglobulin A (IgA) autoantibodies are detectable in the serum of most patients with untreated celiac disease (CD). Their deposits in the intestine of patients with CD with severe enteropathy are considered specific for this condition. The histological spectrum of CD includes cases with normal villous architecture. The aim of this study was to look for anti-TG2 IgA deposits in the intestine of children with normal villous architecture and to relate them with other markers of gluten sensitivity. PATIENTS AND METHODS: A total of 57 children with normal duodenal villous architecture and markers of gluten sensitivity were considered. Of those, 39 showed positive serum anti-endomysium antibodies and/or high levels of anti-TG2 antibodies (group 1), and 18 were seronegative with only a greater density of gammadelta intraepithelial lymphocytes (group 2). Thirty-four children with no markers of gluten sensitivity and a normal mucosa represented the control group (group 3). The duodenal sections of all patients were investigated for deposited anti-TG2 IgA by double immunofluorescence. Human lymphocyte antigen molecular typing was performed. RESULTS: In group 1 and in group 2, 33 of 39 children (85%) and 12 of 18 children (66%) showed subepithelial anti-TG2 IgA intestinal deposits, respectively. Only in 3 of 34 (8.8%) children with no markers of gluten sensitivity were anti-TG2 IgA deposits noted. CONCLUSIONS: A subgroup of children with no serum CD-associated autoantibodies, but greater density of gammadelta intraepithelial lymphocytes, shows a clear anti-TG2 IgA deposition in the duodenal mucosa. These children must be investigated further for possible gluten sensitivity. SN - 1536-4801 UR - https://www.unboundmedicine.com/medline/citation/18728524/Immunoglobulin_A_anti_tissue_transglutaminase_antibody_deposits_in_the_small_intestinal_mucosa_of_children_with_no_villous_atrophy_ L2 - https://doi.org/10.1097/MPG.0b013e3181677067 DB - PRIME DP - Unbound Medicine ER -