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Adiponectin and insulin resistance in childhood obesity.
J Pediatr Gastroenterol Nutr. 2008 Sep; 47(3):356-62.JP

Abstract

OBJECTIVES

To measure adiponectin serum levels in Greek children and adolescents and correlate them with body fat and insulin resistance.

PATIENTS AND METHODS

Forty-six obese prepubertal children (19 M, 27 F) and 34 obese adolescents (17 M, 17 F) ages 9.33 +/- 1.57 and 13.6 +/- 1.42 years, respectively, and 43 matched control individuals were studied. Body mass index standard deviation score and percent body fat were measured by bioelectric impedance analysis. Fasting indices of insulin resistance (HOMA-IR and fasting glucose-to-insulin ratio) were calculated for all participants. Indices of insulin resistance derived from oral glucose tolerance tests were estimated in obese participants. Adiponectin was measured by enzyme-linked immunosorbent assay.

RESULTS

(MEAN +/- SD):: Adiponectin serum levels were significantly lower in obese participants than in nonobese participants (8.11 +/- 3.80 vs 11.81 +/- 4.98 microg/mL, P < 0.001), in obese children than in nonobese children (8.86 +/- 3.86 vs 13.08 +/- 5.48 microg/mL, P < 0.001), in obese adolescents than in nonobese adolescents (7.04 +/- 3.43 vs 10.47 +/- 4.10 microg/mL, P = 0.002), and in obese adolescent boys than in obese adolescent girls (5.87 +/- 3.52 vs 8.31 +/- 3.16 microg/mL, P = 0.042). There were significant correlations between adiponectin and age, body mass index, body mass index standard deviation score, homeostasis model assessment for insulin resistance, and fasting glucose-to-insulin ratio. Adiponectin correlated with percent body fat after adjustment for sex. Adiponectin correlated significantly with several indices of insulin resistance, such as the areas under the curves for glucose and insulin, whole-body insulin sensitivity index, glucose 120', and insulin 30', in obese participants.

CONCLUSIONS

Adiponectin was significantly lower in obese participants than in nonobese participants in general, and it correlated significantly with fasting indices of insulin resistance and with indices derived from oral glucose tolerance tests. It is worthwhile to further investigate the option of applying a simple measurement of serum adiponectin as a screening tool before applying more time-consuming techniques in young obese individuals.

Authors+Show Affiliations

4th Department of Pediatrics, Aristotle University of Thessaloniki, Thessaloniki, Greece. vivi@post.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18728534

Citation

Panagopoulou, Paraskevi, et al. "Adiponectin and Insulin Resistance in Childhood Obesity." Journal of Pediatric Gastroenterology and Nutrition, vol. 47, no. 3, 2008, pp. 356-62.
Panagopoulou P, Galli-Tsinopoulou A, Fleva A, et al. Adiponectin and insulin resistance in childhood obesity. J Pediatr Gastroenterol Nutr. 2008;47(3):356-62.
Panagopoulou, P., Galli-Tsinopoulou, A., Fleva, A., Pavlitou-Tsiontsi, E., Vavatsi-Christaki, N., & Nousia-Arvanitakis, S. (2008). Adiponectin and insulin resistance in childhood obesity. Journal of Pediatric Gastroenterology and Nutrition, 47(3), 356-62. https://doi.org/10.1097/MPG.0b013e31817fcb67
Panagopoulou P, et al. Adiponectin and Insulin Resistance in Childhood Obesity. J Pediatr Gastroenterol Nutr. 2008;47(3):356-62. PubMed PMID: 18728534.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adiponectin and insulin resistance in childhood obesity. AU - Panagopoulou,Paraskevi, AU - Galli-Tsinopoulou,Assimina, AU - Fleva,Alexandra, AU - Pavlitou-Tsiontsi,Ekaterini, AU - Vavatsi-Christaki,Norma, AU - Nousia-Arvanitakis,Sanda, PY - 2008/8/30/pubmed PY - 2008/12/19/medline PY - 2008/8/30/entrez SP - 356 EP - 62 JF - Journal of pediatric gastroenterology and nutrition JO - J. Pediatr. Gastroenterol. Nutr. VL - 47 IS - 3 N2 - OBJECTIVES: To measure adiponectin serum levels in Greek children and adolescents and correlate them with body fat and insulin resistance. PATIENTS AND METHODS: Forty-six obese prepubertal children (19 M, 27 F) and 34 obese adolescents (17 M, 17 F) ages 9.33 +/- 1.57 and 13.6 +/- 1.42 years, respectively, and 43 matched control individuals were studied. Body mass index standard deviation score and percent body fat were measured by bioelectric impedance analysis. Fasting indices of insulin resistance (HOMA-IR and fasting glucose-to-insulin ratio) were calculated for all participants. Indices of insulin resistance derived from oral glucose tolerance tests were estimated in obese participants. Adiponectin was measured by enzyme-linked immunosorbent assay. RESULTS: (MEAN +/- SD):: Adiponectin serum levels were significantly lower in obese participants than in nonobese participants (8.11 +/- 3.80 vs 11.81 +/- 4.98 microg/mL, P < 0.001), in obese children than in nonobese children (8.86 +/- 3.86 vs 13.08 +/- 5.48 microg/mL, P < 0.001), in obese adolescents than in nonobese adolescents (7.04 +/- 3.43 vs 10.47 +/- 4.10 microg/mL, P = 0.002), and in obese adolescent boys than in obese adolescent girls (5.87 +/- 3.52 vs 8.31 +/- 3.16 microg/mL, P = 0.042). There were significant correlations between adiponectin and age, body mass index, body mass index standard deviation score, homeostasis model assessment for insulin resistance, and fasting glucose-to-insulin ratio. Adiponectin correlated with percent body fat after adjustment for sex. Adiponectin correlated significantly with several indices of insulin resistance, such as the areas under the curves for glucose and insulin, whole-body insulin sensitivity index, glucose 120', and insulin 30', in obese participants. CONCLUSIONS: Adiponectin was significantly lower in obese participants than in nonobese participants in general, and it correlated significantly with fasting indices of insulin resistance and with indices derived from oral glucose tolerance tests. It is worthwhile to further investigate the option of applying a simple measurement of serum adiponectin as a screening tool before applying more time-consuming techniques in young obese individuals. SN - 1536-4801 UR - https://www.unboundmedicine.com/medline/citation/18728534/Adiponectin_and_insulin_resistance_in_childhood_obesity_ L2 - https://doi.org/10.1097/MPG.0b013e31817fcb67 DB - PRIME DP - Unbound Medicine ER -