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Plasma factor VII is activated by postprandial triglyceridaemia, irrespective of dietary fat composition.
Atherosclerosis. 1991 Feb; 86(2-3):163-71.A

Abstract

Nine adults took two 7-day diets of standardised energy and total fat content, but with a dietary polyunsaturated/saturated fat ratio of less than 0.3 and greater than 3.0 respectively, while adhering to their daily routine. Blood was drawn on 6 occasions between 09.00 and 22.45 h on the final day of each dietary period for factor VII activity (VIIc), factor VII antigen (VIIag) and lipoprotein lipid concentrations. Diurnal variation was described for each variable in terms of its deviation from the individual's daily mean value at each time point across the day. Plasma triglyceride remained low until after the midday meal, whereafter a marked rise was sustained into the later evening. Plasma VIIc declined until early afternoon, but showed a marked rise in the late afternoon. Plasma VIIag showed no significant diurnal variation. Changes in plasma triglyceride concentration during the day were related positively to changes in VIIc about 160 min later, but not to VIIc at other time points. This effect of postprandial triglyceridaemia on VIIc persisted after allowance for the effect of VIIag on VIIc. Dietary fat composition did not influence VIIc or VIIag. The results suggested an acute but evanescent effect of triglyceride-rich lipoproteins on the reactivity of factor VII, irrespective of their lipid core composition.

Authors+Show Affiliations

MRC Epidemiology and Medical Care Unit, Northwick Park Hospital, Harrow, Middlesex, U.K.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1872911

Citation

Miller, G J., et al. "Plasma Factor VII Is Activated By Postprandial Triglyceridaemia, Irrespective of Dietary Fat Composition." Atherosclerosis, vol. 86, no. 2-3, 1991, pp. 163-71.
Miller GJ, Martin JC, Mitropoulos KA, et al. Plasma factor VII is activated by postprandial triglyceridaemia, irrespective of dietary fat composition. Atherosclerosis. 1991;86(2-3):163-71.
Miller, G. J., Martin, J. C., Mitropoulos, K. A., Reeves, B. E., Thompson, R. L., Meade, T. W., Cooper, J. A., & Cruickshank, J. K. (1991). Plasma factor VII is activated by postprandial triglyceridaemia, irrespective of dietary fat composition. Atherosclerosis, 86(2-3), 163-71.
Miller GJ, et al. Plasma Factor VII Is Activated By Postprandial Triglyceridaemia, Irrespective of Dietary Fat Composition. Atherosclerosis. 1991;86(2-3):163-71. PubMed PMID: 1872911.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma factor VII is activated by postprandial triglyceridaemia, irrespective of dietary fat composition. AU - Miller,G J, AU - Martin,J C, AU - Mitropoulos,K A, AU - Reeves,B E, AU - Thompson,R L, AU - Meade,T W, AU - Cooper,J A, AU - Cruickshank,J K, PY - 1991/2/1/pubmed PY - 1991/2/1/medline PY - 1991/2/1/entrez SP - 163 EP - 71 JF - Atherosclerosis JO - Atherosclerosis VL - 86 IS - 2-3 N2 - Nine adults took two 7-day diets of standardised energy and total fat content, but with a dietary polyunsaturated/saturated fat ratio of less than 0.3 and greater than 3.0 respectively, while adhering to their daily routine. Blood was drawn on 6 occasions between 09.00 and 22.45 h on the final day of each dietary period for factor VII activity (VIIc), factor VII antigen (VIIag) and lipoprotein lipid concentrations. Diurnal variation was described for each variable in terms of its deviation from the individual's daily mean value at each time point across the day. Plasma triglyceride remained low until after the midday meal, whereafter a marked rise was sustained into the later evening. Plasma VIIc declined until early afternoon, but showed a marked rise in the late afternoon. Plasma VIIag showed no significant diurnal variation. Changes in plasma triglyceride concentration during the day were related positively to changes in VIIc about 160 min later, but not to VIIc at other time points. This effect of postprandial triglyceridaemia on VIIc persisted after allowance for the effect of VIIag on VIIc. Dietary fat composition did not influence VIIc or VIIag. The results suggested an acute but evanescent effect of triglyceride-rich lipoproteins on the reactivity of factor VII, irrespective of their lipid core composition. SN - 0021-9150 UR - https://www.unboundmedicine.com/medline/citation/1872911/Plasma_factor_VII_is_activated_by_postprandial_triglyceridaemia_irrespective_of_dietary_fat_composition_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0021-9150(91)90212-L DB - PRIME DP - Unbound Medicine ER -