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A controlled study on the effects of n-3 fatty acids on lipid and glucose metabolism in non-insulin-dependent diabetic patients.
Atherosclerosis 1991; 87(1):65-73A

Abstract

Eight male non-insulin-dependent diabetic patients participated in a double-blind randomized cross-over study (2 weeks for each period) evaluating the effects of 10 g/day fish oil dietary supplementation on glucose and lipid metabolism. Fasting serum triglyceride concentrations were decreased by fish oil because of a reduction in VLDL (1.4 +/- 0.2 vs. 1.9 +/- 0.2 mmol/l, P less than 0.025). LDL cholesterol concentration was instead increased (3.4 +/- 0.3 vs. 2.8 +/- 0.3 mmol/l, P less than 0.025) and net changes in VLDL triglyceride and in LDL cholesterol were inversely correlated (r = -0.86, P less than 0.01). Plasma free fatty acids concentrations and turnover rate [(3H]palmitate method) were similar after fish oil and placebo. Fish oil supplement did not induce significant changes in fasting blood glucose (8.1 +/- 1.1 vs. 8.5 +/- 1.2 mmol/l) and average daily blood glucose (BG) (9.4 +/- 3.2 vs. 9.3 +/- 3.5 mmol/l). Glucose stimulated plasma insulin response during a hyperglycemic clamp was not significantly influenced by fish oil both in the early phase and during steady state. Insulin sensitivity (M/I index) was also unchanged. In conclusion, this study shows that a dietary supplement of fish oil decreases plasma triglyceride levels in non-insulin-dependent diabetic patients, an increased conversion rate of VLDL to LDL playing a role in this change. With this dosage of fish oil no relevant variations in glycemic control, insulin secretion and insulin sensitivity occurred.

Authors+Show Affiliations

Institute of Internal Medicine and Metabolic Diseases, Federico II University, Naples, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1872925

Citation

Annuzzi, G, et al. "A Controlled Study On the Effects of N-3 Fatty Acids On Lipid and Glucose Metabolism in Non-insulin-dependent Diabetic Patients." Atherosclerosis, vol. 87, no. 1, 1991, pp. 65-73.
Annuzzi G, Rivellese A, Capaldo B, et al. A controlled study on the effects of n-3 fatty acids on lipid and glucose metabolism in non-insulin-dependent diabetic patients. Atherosclerosis. 1991;87(1):65-73.
Annuzzi, G., Rivellese, A., Capaldo, B., Di Marino, L., Iovine, C., Marotta, G., & Riccardi, G. (1991). A controlled study on the effects of n-3 fatty acids on lipid and glucose metabolism in non-insulin-dependent diabetic patients. Atherosclerosis, 87(1), pp. 65-73.
Annuzzi G, et al. A Controlled Study On the Effects of N-3 Fatty Acids On Lipid and Glucose Metabolism in Non-insulin-dependent Diabetic Patients. Atherosclerosis. 1991;87(1):65-73. PubMed PMID: 1872925.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A controlled study on the effects of n-3 fatty acids on lipid and glucose metabolism in non-insulin-dependent diabetic patients. AU - Annuzzi,G, AU - Rivellese,A, AU - Capaldo,B, AU - Di Marino,L, AU - Iovine,C, AU - Marotta,G, AU - Riccardi,G, PY - 1991/3/1/pubmed PY - 1991/3/1/medline PY - 1991/3/1/entrez SP - 65 EP - 73 JF - Atherosclerosis JO - Atherosclerosis VL - 87 IS - 1 N2 - Eight male non-insulin-dependent diabetic patients participated in a double-blind randomized cross-over study (2 weeks for each period) evaluating the effects of 10 g/day fish oil dietary supplementation on glucose and lipid metabolism. Fasting serum triglyceride concentrations were decreased by fish oil because of a reduction in VLDL (1.4 +/- 0.2 vs. 1.9 +/- 0.2 mmol/l, P less than 0.025). LDL cholesterol concentration was instead increased (3.4 +/- 0.3 vs. 2.8 +/- 0.3 mmol/l, P less than 0.025) and net changes in VLDL triglyceride and in LDL cholesterol were inversely correlated (r = -0.86, P less than 0.01). Plasma free fatty acids concentrations and turnover rate [(3H]palmitate method) were similar after fish oil and placebo. Fish oil supplement did not induce significant changes in fasting blood glucose (8.1 +/- 1.1 vs. 8.5 +/- 1.2 mmol/l) and average daily blood glucose (BG) (9.4 +/- 3.2 vs. 9.3 +/- 3.5 mmol/l). Glucose stimulated plasma insulin response during a hyperglycemic clamp was not significantly influenced by fish oil both in the early phase and during steady state. Insulin sensitivity (M/I index) was also unchanged. In conclusion, this study shows that a dietary supplement of fish oil decreases plasma triglyceride levels in non-insulin-dependent diabetic patients, an increased conversion rate of VLDL to LDL playing a role in this change. With this dosage of fish oil no relevant variations in glycemic control, insulin secretion and insulin sensitivity occurred. SN - 0021-9150 UR - https://www.unboundmedicine.com/medline/citation/1872925/A_controlled_study_on_the_effects_of_n_3_fatty_acids_on_lipid_and_glucose_metabolism_in_non_insulin_dependent_diabetic_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0021-9150(91)90233-S DB - PRIME DP - Unbound Medicine ER -