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Quantitation of methylxanthinic alkaloids and phenolic compounds in mate (Ilex paraguariensis) and their effects on blood vessel formation in chick embryos.
J Agric Food Chem. 2008 Sep 24; 56(18):8348-53.JA

Abstract

Methylxanthinic alkaloids and phenolic compounds are related to the therapeutic properties of Ilex paraguariensis infusions. Considering the known vascular tropism of xanthines, an aqueous extract (mate) and caffeine were evaluated on blood vessel formation, in connection with the analysis of those secondary metabolites, which was performed in young and mature leaf samples collected in three cultivation systems located in the southern region in Brazil (Santa Catarina State). Samples of young and mature leaves from a monoculture cultivation system (MC) showed the highest content of phenolic compounds (149.68 microg/mL, young leaves; 135.50 microg/mL, mature leaves) and caffeine (young leaves, 148.07 microg/mL; mature leaves, 244.63 microg/mL) as compared to samples from agroforesty (AF) and shaded-native (NT) cultures. Theophylline was not detected in samples by reverse phase-high performance liquid chromatography, and mature leaves showed lower theobromine amounts (11.46 microg/mL). Treatments performed with mate aqueous extract and caffeine (1.03-4.12 microM/disk) in the yolk sac vascular membranes of 2-day-old chick embryos revealed pro-vasculo- and angiogenic properties as well as embryonic growth enhancement. These findings, uncoupled from any detectable embryotoxic effect, suggest a potential therapeutic and/or prophylactic use in cardiovascular disorders for caffeine and related constituents of mate plant extracts, an issue that waits further studies.

Authors+Show Affiliations

Laboratory of Plant Morphogenesis and Biochemistry, Department of Plant Science, Federal University of Santa Catarina, Florianopolis, SC, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18729465

Citation

Strassmann, Betina B., et al. "Quantitation of Methylxanthinic Alkaloids and Phenolic Compounds in Mate (Ilex Paraguariensis) and Their Effects On Blood Vessel Formation in Chick Embryos." Journal of Agricultural and Food Chemistry, vol. 56, no. 18, 2008, pp. 8348-53.
Strassmann BB, Vieira AR, Pedrotti EL, et al. Quantitation of methylxanthinic alkaloids and phenolic compounds in mate (Ilex paraguariensis) and their effects on blood vessel formation in chick embryos. J Agric Food Chem. 2008;56(18):8348-53.
Strassmann, B. B., Vieira, A. R., Pedrotti, E. L., Morais, H. N., Dias, P. F., & Maraschin, M. (2008). Quantitation of methylxanthinic alkaloids and phenolic compounds in mate (Ilex paraguariensis) and their effects on blood vessel formation in chick embryos. Journal of Agricultural and Food Chemistry, 56(18), 8348-53. https://doi.org/10.1021/jf801041f
Strassmann BB, et al. Quantitation of Methylxanthinic Alkaloids and Phenolic Compounds in Mate (Ilex Paraguariensis) and Their Effects On Blood Vessel Formation in Chick Embryos. J Agric Food Chem. 2008 Sep 24;56(18):8348-53. PubMed PMID: 18729465.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantitation of methylxanthinic alkaloids and phenolic compounds in mate (Ilex paraguariensis) and their effects on blood vessel formation in chick embryos. AU - Strassmann,Betina B, AU - Vieira,Ana R, AU - Pedrotti,Enio L, AU - Morais,Hiliana N F, AU - Dias,Paulo F, AU - Maraschin,Marcelo, Y1 - 2008/08/27/ PY - 2008/8/30/pubmed PY - 2008/11/11/medline PY - 2008/8/30/entrez SP - 8348 EP - 53 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 56 IS - 18 N2 - Methylxanthinic alkaloids and phenolic compounds are related to the therapeutic properties of Ilex paraguariensis infusions. Considering the known vascular tropism of xanthines, an aqueous extract (mate) and caffeine were evaluated on blood vessel formation, in connection with the analysis of those secondary metabolites, which was performed in young and mature leaf samples collected in three cultivation systems located in the southern region in Brazil (Santa Catarina State). Samples of young and mature leaves from a monoculture cultivation system (MC) showed the highest content of phenolic compounds (149.68 microg/mL, young leaves; 135.50 microg/mL, mature leaves) and caffeine (young leaves, 148.07 microg/mL; mature leaves, 244.63 microg/mL) as compared to samples from agroforesty (AF) and shaded-native (NT) cultures. Theophylline was not detected in samples by reverse phase-high performance liquid chromatography, and mature leaves showed lower theobromine amounts (11.46 microg/mL). Treatments performed with mate aqueous extract and caffeine (1.03-4.12 microM/disk) in the yolk sac vascular membranes of 2-day-old chick embryos revealed pro-vasculo- and angiogenic properties as well as embryonic growth enhancement. These findings, uncoupled from any detectable embryotoxic effect, suggest a potential therapeutic and/or prophylactic use in cardiovascular disorders for caffeine and related constituents of mate plant extracts, an issue that waits further studies. SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/18729465/Quantitation_of_methylxanthinic_alkaloids_and_phenolic_compounds_in_mate__Ilex_paraguariensis__and_their_effects_on_blood_vessel_formation_in_chick_embryos_ DB - PRIME DP - Unbound Medicine ER -