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Exercise is associated with reduction in the anxiogenic effect of mCPP on acoustic startle.
Behav Neurosci. 2008 Aug; 122(4):943-8.BN

Abstract

Voluntary exercise has been associated with reduced anxiety across several animal models. Manipulation of central 5-HT can alter anxiety-like behaviors and administration of the 5-HT agonist metachlorophenylpiperazine (mCPP) increases anxiety in rodents and humans. To examine whether the anxiolytic effect of exercise is associated with an alteration in 5-HT systems, we examined the anxiogenic effect of mCPP in exercising and nonexercising mice. C57BL/6J mice were given 2 weeks of free access to either a functioning or nonfunctioning running wheel. Mice were then tested for acoustic startle following systemic injection of either 0, 0.1, 0.3, or 1 mg/kg of mCPP. Consistent with its anxiogenic properties, mCPP produced a dose-dependent increase in acoustic startle in nonexercising mice. However, this anxiogenic effect was blunted in exercising mice. These findings suggest that exercise may help to reduce anxiety by altering 5-HT systems, perhaps by down-regulating postsynaptic 5HT 2B/2C receptors.

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Authors+Show Affiliations

Fox JH
Department of Psychology, University of Vermont, Burlington, VT 05405, USA.
Hammack SE
No affiliation info available
Falls WA
No affiliation info available

MeSH

Acoustic StimulationAnalysis of VarianceAnimalsAnxietyBehavior, AnimalDisease Models, AnimalDose-Response Relationship, DrugMaleMiceMice, Inbred C57BLPhysical Conditioning, AnimalPiperazinesReflex, StartleSerotonin Receptor Agonists

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18729648

Citation

Fox, James H., et al. "Exercise Is Associated With Reduction in the Anxiogenic Effect of mCPP On Acoustic Startle." Behavioral Neuroscience, vol. 122, no. 4, 2008, pp. 943-8.
Fox JH, Hammack SE, Falls WA. Exercise is associated with reduction in the anxiogenic effect of mCPP on acoustic startle. Behav Neurosci. 2008;122(4):943-8.
Fox, J. H., Hammack, S. E., & Falls, W. A. (2008). Exercise is associated with reduction in the anxiogenic effect of mCPP on acoustic startle. Behavioral Neuroscience, 122(4), 943-8. https://doi.org/10.1037/0735-7044.122.4.943
Fox JH, Hammack SE, Falls WA. Exercise Is Associated With Reduction in the Anxiogenic Effect of mCPP On Acoustic Startle. Behav Neurosci. 2008;122(4):943-8. PubMed PMID: 18729648.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exercise is associated with reduction in the anxiogenic effect of mCPP on acoustic startle. AU - Fox,James H, AU - Hammack,Sayamwong E, AU - Falls,William A, PY - 2008/8/30/pubmed PY - 2008/11/6/medline PY - 2008/8/30/entrez SP - 943 EP - 8 JF - Behavioral neuroscience JO - Behav Neurosci VL - 122 IS - 4 N2 - Voluntary exercise has been associated with reduced anxiety across several animal models. Manipulation of central 5-HT can alter anxiety-like behaviors and administration of the 5-HT agonist metachlorophenylpiperazine (mCPP) increases anxiety in rodents and humans. To examine whether the anxiolytic effect of exercise is associated with an alteration in 5-HT systems, we examined the anxiogenic effect of mCPP in exercising and nonexercising mice. C57BL/6J mice were given 2 weeks of free access to either a functioning or nonfunctioning running wheel. Mice were then tested for acoustic startle following systemic injection of either 0, 0.1, 0.3, or 1 mg/kg of mCPP. Consistent with its anxiogenic properties, mCPP produced a dose-dependent increase in acoustic startle in nonexercising mice. However, this anxiogenic effect was blunted in exercising mice. These findings suggest that exercise may help to reduce anxiety by altering 5-HT systems, perhaps by down-regulating postsynaptic 5HT 2B/2C receptors. SN - 0735-7044 UR - https://www.unboundmedicine.com/medline/citation/18729648/Exercise_is_associated_with_reduction_in_the_anxiogenic_effect_of_mCPP_on_acoustic_startle_ L2 - http://content.apa.org/journals/bne/122/4/943 DB - PRIME DP - Unbound Medicine ER -