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[Stratum corneum and nail lipids in patients with atopic dermatitis. Decrease in ceramides--a pathogenetic factor in atopic xerosis?].
Hautarzt. 1991 May; 42(5):302-6.H

Abstract

Dry skin is seen in many patients with atopic dermatitis and correlates with a disturbed epidermal barrier function demonstrated by such features as increased transepidermal water loss and diminished stratum corneum hydration. With regard to the importance of stratum corneum lipids for the permeability barrier, we have analysed plantar (n = 8) and lumbar (n = 20) stratum corneum and nail lipids (n = 15) of atopic subjects by high-performance thin-layer chromatography (HPTLC). Compared with controls our investigations show a decrease in the ceramide fraction as a percentage of total lipid and a diminished ratio of ceramides and free sterols in atopic subjects. This implies that impaired ceramide synthesis may be a factor in the pathogenesis of atopic xerosis.

Authors+Show Affiliations

Hautklinik, Heinrich-Heine-Universität Düsseldorf.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

ger

PubMed ID

1874619

Citation

Hollmann, J, et al. "[Stratum Corneum and Nail Lipids in Patients With Atopic Dermatitis. Decrease in Ceramides--a Pathogenetic Factor in Atopic Xerosis?]." Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete, vol. 42, no. 5, 1991, pp. 302-6.
Hollmann J, Melnik BC, Lee MS, et al. [Stratum corneum and nail lipids in patients with atopic dermatitis. Decrease in ceramides--a pathogenetic factor in atopic xerosis?]. Hautarzt. 1991;42(5):302-6.
Hollmann, J., Melnik, B. C., Lee, M. S., Hofmann, U., & Plewig, G. (1991). [Stratum corneum and nail lipids in patients with atopic dermatitis. Decrease in ceramides--a pathogenetic factor in atopic xerosis?]. Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete, 42(5), 302-6.
Hollmann J, et al. [Stratum Corneum and Nail Lipids in Patients With Atopic Dermatitis. Decrease in Ceramides--a Pathogenetic Factor in Atopic Xerosis?]. Hautarzt. 1991;42(5):302-6. PubMed PMID: 1874619.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Stratum corneum and nail lipids in patients with atopic dermatitis. Decrease in ceramides--a pathogenetic factor in atopic xerosis?]. AU - Hollmann,J, AU - Melnik,B C, AU - Lee,M S, AU - Hofmann,U, AU - Plewig,G, PY - 1991/5/1/pubmed PY - 1991/5/1/medline PY - 1991/5/1/entrez SP - 302 EP - 6 JF - Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete JO - Hautarzt VL - 42 IS - 5 N2 - Dry skin is seen in many patients with atopic dermatitis and correlates with a disturbed epidermal barrier function demonstrated by such features as increased transepidermal water loss and diminished stratum corneum hydration. With regard to the importance of stratum corneum lipids for the permeability barrier, we have analysed plantar (n = 8) and lumbar (n = 20) stratum corneum and nail lipids (n = 15) of atopic subjects by high-performance thin-layer chromatography (HPTLC). Compared with controls our investigations show a decrease in the ceramide fraction as a percentage of total lipid and a diminished ratio of ceramides and free sterols in atopic subjects. This implies that impaired ceramide synthesis may be a factor in the pathogenesis of atopic xerosis. SN - 0017-8470 UR - https://www.unboundmedicine.com/medline/citation/1874619/[Stratum_corneum_and_nail_lipids_in_patients_with_atopic_dermatitis__Decrease_in_ceramides__a_pathogenetic_factor_in_atopic_xerosis]_ L2 - https://www.diseaseinfosearch.org/result/9652 DB - PRIME DP - Unbound Medicine ER -
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