Tags

Type your tag names separated by a space and hit enter

The impact of surgical treatment and poor prognostic factors for patients with intrahepatic cholangiocarcinoma: retrospective analysis of 60 patients.
Anticancer Res. 2008 Jul-Aug; 28(4C):2353-9.AR

Abstract

BACKGROUND

Intrahepatic cholangiocarcinoma (ICC) is a primary adenocarcinoma of the liver arising from the intrahepatic bile duct. Hepatectomy with extensive lymph node dissection is the standard treatment for ICC.

PATIENTS AND METHODS

Sixty patients with ICC who underwent hepatectomy in our institution between 1986 and 2005 were investigated to determine prognostic factors and to evaluate the impact of surgical treatment for ICC using univariate and multivariate analyses.

RESULTS

The overall survival rate of the R0 resection group (n=43) was significantly higher than that of the R1/2 group (n=17). However, in patients with lymph node metastasis (n=24), R0 resection had no survival impact. According to multivariate analysis, the independent factors of poor prognosis were: the presence of lymph node metastasis, lymphatic invasion, poor differentiation and R1/2 resection.

CONCLUSION

R0 resection can provide prolonged survival for patients with ICC. Patients with lymph node metastasis, lymphatic invasion, or poorly differentiated ICC have poor prognosis after operation and additional treatment, such as adjuvant chemotherapy, is recommended.

Authors+Show Affiliations

Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. yamashi@surg2.med.kyushu-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18751418

Citation

Yamashita, Yo-ichi, et al. "The Impact of Surgical Treatment and Poor Prognostic Factors for Patients With Intrahepatic Cholangiocarcinoma: Retrospective Analysis of 60 Patients." Anticancer Research, vol. 28, no. 4C, 2008, pp. 2353-9.
Yamashita Y, Taketomi A, Morita K, et al. The impact of surgical treatment and poor prognostic factors for patients with intrahepatic cholangiocarcinoma: retrospective analysis of 60 patients. Anticancer Res. 2008;28(4C):2353-9.
Yamashita, Y., Taketomi, A., Morita, K., Fukuhara, T., Ueda, S., Sanefuji, K., Iguchi, T., Kayashima, H., Sugimachi, K., & Maehara, Y. (2008). The impact of surgical treatment and poor prognostic factors for patients with intrahepatic cholangiocarcinoma: retrospective analysis of 60 patients. Anticancer Research, 28(4C), 2353-9.
Yamashita Y, et al. The Impact of Surgical Treatment and Poor Prognostic Factors for Patients With Intrahepatic Cholangiocarcinoma: Retrospective Analysis of 60 Patients. Anticancer Res. 2008 Jul-Aug;28(4C):2353-9. PubMed PMID: 18751418.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The impact of surgical treatment and poor prognostic factors for patients with intrahepatic cholangiocarcinoma: retrospective analysis of 60 patients. AU - Yamashita,Yo-ichi, AU - Taketomi,Akinobu, AU - Morita,Kazutoyo, AU - Fukuhara,Takasuke, AU - Ueda,Shigeru, AU - Sanefuji,Kensaku, AU - Iguchi,Tomohiro, AU - Kayashima,Hiroto, AU - Sugimachi,Keishi, AU - Maehara,Yoshihiko, PY - 2008/8/30/pubmed PY - 2008/9/10/medline PY - 2008/8/30/entrez SP - 2353 EP - 9 JF - Anticancer research JO - Anticancer Res VL - 28 IS - 4C N2 - BACKGROUND: Intrahepatic cholangiocarcinoma (ICC) is a primary adenocarcinoma of the liver arising from the intrahepatic bile duct. Hepatectomy with extensive lymph node dissection is the standard treatment for ICC. PATIENTS AND METHODS: Sixty patients with ICC who underwent hepatectomy in our institution between 1986 and 2005 were investigated to determine prognostic factors and to evaluate the impact of surgical treatment for ICC using univariate and multivariate analyses. RESULTS: The overall survival rate of the R0 resection group (n=43) was significantly higher than that of the R1/2 group (n=17). However, in patients with lymph node metastasis (n=24), R0 resection had no survival impact. According to multivariate analysis, the independent factors of poor prognosis were: the presence of lymph node metastasis, lymphatic invasion, poor differentiation and R1/2 resection. CONCLUSION: R0 resection can provide prolonged survival for patients with ICC. Patients with lymph node metastasis, lymphatic invasion, or poorly differentiated ICC have poor prognosis after operation and additional treatment, such as adjuvant chemotherapy, is recommended. SN - 0250-7005 UR - https://www.unboundmedicine.com/medline/citation/18751418/The_impact_of_surgical_treatment_and_poor_prognostic_factors_for_patients_with_intrahepatic_cholangiocarcinoma:_retrospective_analysis_of_60_patients_ L2 - http://ar.iiarjournals.org/cgi/pmidlookup?view=long&pmid=18751418 DB - PRIME DP - Unbound Medicine ER -