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Alcohol consumption, type of alcoholic beverage and risk of colorectal cancer at specific subsites.
Int J Cancer 2008; 123(10):2411-7IJ

Abstract

Within the Netherlands Cohort Study on diet and cancer, we investigated associations between total alcohol consumption, specific alcoholic beverage consumption and risk of colorectal cancer (CRC) according to anatomical subsite. Hazard Ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional hazards models. Analyses were performed on 2,323 CRC cases, available after 13.3 years of follow-up. Compared to abstaining, alcohol consumption of >/=30.0 g/day (approximately 3 alcoholic drinks) was positively associated with the risk of CRC (HR: 1.32, 95% CI: 1.06-1.65). Analyses restricted to subjects who reported to have consumed equal amounts of alcohol 5 years before baseline compared to baseline, showed elevated risk estimates for consumers of >/=30.0 g of total alcohol per day as well (HR: 1.53, 95% CI: 1.16-2.01). Suggestive of a subsite-specific effect, cancer risk seemed to increase from proximal colon through rectum; HR: 1.29, 95% CI: 0.85-1.96 for proximal colon cancer, HR: 1.41, 95% CI: 0.94-2.11 for distal colon cancer, HR: 2.07, 95% CI: 1.03-4.18 for rectosigmoid cancer and HR: 1.69, 95% CI: 1.08-2.64 for rectal cancer. No associations were observed between consumption of alcoholic beverages and CRC risk when compared with the nondrinkers of the specific beverage and after adjustment for total alcohol intake. No evidence was found for sex-specific effects of alcohol and alcoholic beverages. In conclusion, our data showed a positive association between alcohol consumption and risk of CRC, which seemed to be mainly explained by the alcoholic content of alcoholic beverages, rather than other constituents. Also, cancer risk may vary according to anatomical subsite.

Authors+Show Affiliations

Department of Epidemiology, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands. brenda.bongaerts@epid.unimaas.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18752250

Citation

Bongaerts, Brenda W C., et al. "Alcohol Consumption, Type of Alcoholic Beverage and Risk of Colorectal Cancer at Specific Subsites." International Journal of Cancer, vol. 123, no. 10, 2008, pp. 2411-7.
Bongaerts BW, van den Brandt PA, Goldbohm RA, et al. Alcohol consumption, type of alcoholic beverage and risk of colorectal cancer at specific subsites. Int J Cancer. 2008;123(10):2411-7.
Bongaerts, B. W., van den Brandt, P. A., Goldbohm, R. A., de Goeij, A. F., & Weijenberg, M. P. (2008). Alcohol consumption, type of alcoholic beverage and risk of colorectal cancer at specific subsites. International Journal of Cancer, 123(10), pp. 2411-7. doi:10.1002/ijc.23774.
Bongaerts BW, et al. Alcohol Consumption, Type of Alcoholic Beverage and Risk of Colorectal Cancer at Specific Subsites. Int J Cancer. 2008 Nov 15;123(10):2411-7. PubMed PMID: 18752250.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol consumption, type of alcoholic beverage and risk of colorectal cancer at specific subsites. AU - Bongaerts,Brenda W C, AU - van den Brandt,Piet A, AU - Goldbohm,R Alexandra, AU - de Goeij,Anton F P M, AU - Weijenberg,Matty P, PY - 2008/8/30/pubmed PY - 2008/10/11/medline PY - 2008/8/30/entrez SP - 2411 EP - 7 JF - International journal of cancer JO - Int. J. Cancer VL - 123 IS - 10 N2 - Within the Netherlands Cohort Study on diet and cancer, we investigated associations between total alcohol consumption, specific alcoholic beverage consumption and risk of colorectal cancer (CRC) according to anatomical subsite. Hazard Ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional hazards models. Analyses were performed on 2,323 CRC cases, available after 13.3 years of follow-up. Compared to abstaining, alcohol consumption of >/=30.0 g/day (approximately 3 alcoholic drinks) was positively associated with the risk of CRC (HR: 1.32, 95% CI: 1.06-1.65). Analyses restricted to subjects who reported to have consumed equal amounts of alcohol 5 years before baseline compared to baseline, showed elevated risk estimates for consumers of >/=30.0 g of total alcohol per day as well (HR: 1.53, 95% CI: 1.16-2.01). Suggestive of a subsite-specific effect, cancer risk seemed to increase from proximal colon through rectum; HR: 1.29, 95% CI: 0.85-1.96 for proximal colon cancer, HR: 1.41, 95% CI: 0.94-2.11 for distal colon cancer, HR: 2.07, 95% CI: 1.03-4.18 for rectosigmoid cancer and HR: 1.69, 95% CI: 1.08-2.64 for rectal cancer. No associations were observed between consumption of alcoholic beverages and CRC risk when compared with the nondrinkers of the specific beverage and after adjustment for total alcohol intake. No evidence was found for sex-specific effects of alcohol and alcoholic beverages. In conclusion, our data showed a positive association between alcohol consumption and risk of CRC, which seemed to be mainly explained by the alcoholic content of alcoholic beverages, rather than other constituents. Also, cancer risk may vary according to anatomical subsite. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/18752250/Alcohol_consumption_type_of_alcoholic_beverage_and_risk_of_colorectal_cancer_at_specific_subsites_ L2 - https://doi.org/10.1002/ijc.23774 DB - PRIME DP - Unbound Medicine ER -