Tags

Type your tag names separated by a space and hit enter

Cognitive and emotional modulation of brain default operation.
J Cogn Neurosci. 2009 Jun; 21(6):1065-80.JC

Abstract

Goal-directed behavior lowers activity in brain areas that include the medial frontal cortex, the medial and lateral parietal cortex, and limbic and paralimbic brain regions, commonly referred to as the "default network." These activity decreases are believed to reflect the interruption of processes that are ongoing when the mind is in a restful state. Previously, the nature of these processes was probed by varying cognitive task parameters, but the presence of emotional processes, while often assumed, was little investigated. With fMRI, we studied the effect of systematic variations of both cognitive load and emotional stimulus connotation on task-related decreases in the default network by employing an auditory working memory (WM) task with musical sounds. The performance of the WM task, compared to passive listening, lowered the activity in medial and lateral, prefrontal, parietal, temporal, and limbic regions. In a subset of these regions, the magnitude of decrease depended on the memory load; the greater the cognitive load, the larger the magnitude of the observed decrease. Furthermore, in the right amygdala and the left precuneus, areas previously associated with processing of unpleasant dissonant musical sounds, there was an interaction between the experimental condition and the stimulus type. The current results are consistent with the previously reported effect of task difficulty on task-related brain activation decreases. The results also indicate that task-related decreases may be further modulated by the emotional stimulus connotation.

Authors+Show Affiliations

Center of Functionally Integrative Neuroscience, Aarhus University Hospitals, Denmark. karenjohanne@pet.auh.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18752396

Citation

Pallesen, Karen Johanne, et al. "Cognitive and Emotional Modulation of Brain Default Operation." Journal of Cognitive Neuroscience, vol. 21, no. 6, 2009, pp. 1065-80.
Pallesen KJ, Brattico E, Bailey CJ, et al. Cognitive and emotional modulation of brain default operation. J Cogn Neurosci. 2009;21(6):1065-80.
Pallesen, K. J., Brattico, E., Bailey, C. J., Korvenoja, A., & Gjedde, A. (2009). Cognitive and emotional modulation of brain default operation. Journal of Cognitive Neuroscience, 21(6), 1065-80. https://doi.org/10.1162/jocn.2009.21086
Pallesen KJ, et al. Cognitive and Emotional Modulation of Brain Default Operation. J Cogn Neurosci. 2009;21(6):1065-80. PubMed PMID: 18752396.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cognitive and emotional modulation of brain default operation. AU - Pallesen,Karen Johanne, AU - Brattico,Elvira, AU - Bailey,Christopher J, AU - Korvenoja,Antti, AU - Gjedde,Albert, PY - 2008/8/30/pubmed PY - 2009/8/13/medline PY - 2008/8/30/entrez SP - 1065 EP - 80 JF - Journal of cognitive neuroscience JO - J Cogn Neurosci VL - 21 IS - 6 N2 - Goal-directed behavior lowers activity in brain areas that include the medial frontal cortex, the medial and lateral parietal cortex, and limbic and paralimbic brain regions, commonly referred to as the "default network." These activity decreases are believed to reflect the interruption of processes that are ongoing when the mind is in a restful state. Previously, the nature of these processes was probed by varying cognitive task parameters, but the presence of emotional processes, while often assumed, was little investigated. With fMRI, we studied the effect of systematic variations of both cognitive load and emotional stimulus connotation on task-related decreases in the default network by employing an auditory working memory (WM) task with musical sounds. The performance of the WM task, compared to passive listening, lowered the activity in medial and lateral, prefrontal, parietal, temporal, and limbic regions. In a subset of these regions, the magnitude of decrease depended on the memory load; the greater the cognitive load, the larger the magnitude of the observed decrease. Furthermore, in the right amygdala and the left precuneus, areas previously associated with processing of unpleasant dissonant musical sounds, there was an interaction between the experimental condition and the stimulus type. The current results are consistent with the previously reported effect of task difficulty on task-related brain activation decreases. The results also indicate that task-related decreases may be further modulated by the emotional stimulus connotation. SN - 0898-929X UR - https://www.unboundmedicine.com/medline/citation/18752396/Cognitive_and_emotional_modulation_of_brain_default_operation_ L2 - http://www.mitpressjournals.org/doi/full/10.1162/jocn.2009.21086?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -