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Incidence and predictors of severe liver fibrosis in HIV-infected patients with chronic hepatitis C in Brazil.
AIDS Patient Care STDS. 2008 Sep; 22(9):701-7.AP

Abstract

The aim of this study was to examine the incidence and factors associated with the severity of liver fibrosis in 234 coinfected patients in Brazil. Patients were cared for in our clinic, from 1996 to 2004. Eligible patients were defined as patients with documented HIV and hepatitis C virus (HCV) infections and had previously undergone a liver biopsy. Patients with persistently normal alanine aminotransferase (ALT) were also included. The variables selected for study were age, gender, risk category, history of high alcohol consumption, CD4(+) T cell count, antiretroviral therapy usage, HCV genotype and duration of HCV infection. Stage of fibrosis was scored as follows: F0, no fibrosis; F1, portal fibrosis with no septa; F2, portal fibrosis with few septa; F3, bridging fibrosis with many septa; and F4, cirrhosis. The liver fibrosis stage was F3 in 39 (16.6%) and F4 in 20(8.5%) patients. Among patients with normal ALT, the liver fibrosis stage was F3-F4 in three patients (5.6%). Predictors of severe liver fibrosis (F3-F4) by multivariate analysis were age (older patients) and genotype 3 (genotype 1 = odds ratio [OR], 0.28; 95% confidence interval [CI], 0.12 0.65). In summary, in the present study severe liver fibrosis was found in 25% of our patients and was associated with an age of more than 38 years at the time of liver biopsy as well as, HCV genotype 3. No differences were found with respect to CD4(+) T cell counts although patients with a CD4(+) T cell count greater than 50 were excluded.

Authors+Show Affiliations

Casa da AIDS, Division of Infectious Diseases, Hospital das Clinicas, University of Säo Paulo, São Paulo, Brazil. cassiamc@uol.com.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18752463

Citation

Mendes-Correa, Maria Cássia, et al. "Incidence and Predictors of Severe Liver Fibrosis in HIV-infected Patients With Chronic Hepatitis C in Brazil." AIDS Patient Care and STDs, vol. 22, no. 9, 2008, pp. 701-7.
Mendes-Correa MC, Widman A, Brussi ML, et al. Incidence and predictors of severe liver fibrosis in HIV-infected patients with chronic hepatitis C in Brazil. AIDS Patient Care STDS. 2008;22(9):701-7.
Mendes-Correa, M. C., Widman, A., Brussi, M. L., Guastini, C. F., & Gianini, R. J. (2008). Incidence and predictors of severe liver fibrosis in HIV-infected patients with chronic hepatitis C in Brazil. AIDS Patient Care and STDs, 22(9), 701-7. https://doi.org/10.1089/apc.2007.0216
Mendes-Correa MC, et al. Incidence and Predictors of Severe Liver Fibrosis in HIV-infected Patients With Chronic Hepatitis C in Brazil. AIDS Patient Care STDS. 2008;22(9):701-7. PubMed PMID: 18752463.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incidence and predictors of severe liver fibrosis in HIV-infected patients with chronic hepatitis C in Brazil. AU - Mendes-Correa,Maria Cássia, AU - Widman,Azzo, AU - Brussi,Maria Luiza Paes, AU - Guastini,Cristina Fátima, AU - Gianini,Reinaldo José, PY - 2008/8/30/pubmed PY - 2008/11/14/medline PY - 2008/8/30/entrez SP - 701 EP - 7 JF - AIDS patient care and STDs JO - AIDS Patient Care STDS VL - 22 IS - 9 N2 - The aim of this study was to examine the incidence and factors associated with the severity of liver fibrosis in 234 coinfected patients in Brazil. Patients were cared for in our clinic, from 1996 to 2004. Eligible patients were defined as patients with documented HIV and hepatitis C virus (HCV) infections and had previously undergone a liver biopsy. Patients with persistently normal alanine aminotransferase (ALT) were also included. The variables selected for study were age, gender, risk category, history of high alcohol consumption, CD4(+) T cell count, antiretroviral therapy usage, HCV genotype and duration of HCV infection. Stage of fibrosis was scored as follows: F0, no fibrosis; F1, portal fibrosis with no septa; F2, portal fibrosis with few septa; F3, bridging fibrosis with many septa; and F4, cirrhosis. The liver fibrosis stage was F3 in 39 (16.6%) and F4 in 20(8.5%) patients. Among patients with normal ALT, the liver fibrosis stage was F3-F4 in three patients (5.6%). Predictors of severe liver fibrosis (F3-F4) by multivariate analysis were age (older patients) and genotype 3 (genotype 1 = odds ratio [OR], 0.28; 95% confidence interval [CI], 0.12 0.65). In summary, in the present study severe liver fibrosis was found in 25% of our patients and was associated with an age of more than 38 years at the time of liver biopsy as well as, HCV genotype 3. No differences were found with respect to CD4(+) T cell counts although patients with a CD4(+) T cell count greater than 50 were excluded. SN - 1557-7449 UR - https://www.unboundmedicine.com/medline/citation/18752463/Incidence_and_predictors_of_severe_liver_fibrosis_in_HIV_infected_patients_with_chronic_hepatitis_C_in_Brazil_ L2 - https://www.liebertpub.com/doi/10.1089/apc.2007.0216?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -