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Methicillin-resistant Staphylococcus aureus: risk factors associated with community-onset infections in Denmark.
Clin Microbiol Infect. 2008 Oct; 14(10):942-8.CM

Abstract

The proportion of methicillin-resistant Staphylococcus aureus (MRSA) in Denmark has been below 1% for more than 30 years. However, a marked increase in community-onset MRSA (CO-MRSA) started in 2002. To identify possible risk factors for CO-MRSA infections, a nationwide case-control study was conducted in 2004. Cases (34) were patients with CO-MRSA infections; controls (87) were patients with community-onset methicillin-sensitive S. aureus infections (CO-MSSA). Demographic and clinical data and exposures to possible risk factors during the last 24 months were collected with a structured telephone-administered questionnaire. Skin and soft tissue were the predominant sites of infection, both for cases (68%) and for controls (60%). A large proportion of cases (26%) and controls (38%) had an underlying skin disease. The majority of cases (76%) and controls (61%) had received antibiotics within the last 6 months, and 51% and 31%, respectively, had been hospitalized within the previous year. In a multivariate analysis, non-Danish origin, defined as being from or having parents from outside Denmark, was the only independent risk factor for CO-MRSA infection (OR 30.5, 95% CI 3.6-257.3). Prior hospitalization for >7 days within the previous 6 months tended to be associated with CO-MRSA infection (OR 5.7, 95% CI 0.9-36.4). The predominant MRSA clones found in this study were CC80 (26%), CC8 (24%) and CC5 (18%). Resistance to three or more antimicrobial drug classes was seen in 47% of CO-MRSA isolates. Panton-Valentine leukocidin was found in 47% of CO-MRSA isolates. Apart from a non-Danish origin, CO-MRSA shared the same risk factors as CO-MSSA, which makes control a challenge.

Authors+Show Affiliations

National Centre for Antimicrobials and Infection Control, Statens Serum Institut, Copenhagen, Denmark. sbc@ssi.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18752595

Citation

Böcher, S, et al. "Methicillin-resistant Staphylococcus Aureus: Risk Factors Associated With Community-onset Infections in Denmark." Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, vol. 14, no. 10, 2008, pp. 942-8.
Böcher S, Gervelmeyer A, Monnet DL, et al. Methicillin-resistant Staphylococcus aureus: risk factors associated with community-onset infections in Denmark. Clin Microbiol Infect. 2008;14(10):942-8.
Böcher, S., Gervelmeyer, A., Monnet, D. L., Mølbak, K., & Skov, R. L. (2008). Methicillin-resistant Staphylococcus aureus: risk factors associated with community-onset infections in Denmark. Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 14(10), 942-8. https://doi.org/10.1111/j.1469-0691.2008.02055.x
Böcher S, et al. Methicillin-resistant Staphylococcus Aureus: Risk Factors Associated With Community-onset Infections in Denmark. Clin Microbiol Infect. 2008;14(10):942-8. PubMed PMID: 18752595.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Methicillin-resistant Staphylococcus aureus: risk factors associated with community-onset infections in Denmark. AU - Böcher,S, AU - Gervelmeyer,A, AU - Monnet,D L, AU - Mølbak,K, AU - Skov,R L, AU - ,, Y1 - 2008/08/26/ PY - 2008/8/30/pubmed PY - 2008/11/7/medline PY - 2008/8/30/entrez SP - 942 EP - 8 JF - Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases JO - Clin Microbiol Infect VL - 14 IS - 10 N2 - The proportion of methicillin-resistant Staphylococcus aureus (MRSA) in Denmark has been below 1% for more than 30 years. However, a marked increase in community-onset MRSA (CO-MRSA) started in 2002. To identify possible risk factors for CO-MRSA infections, a nationwide case-control study was conducted in 2004. Cases (34) were patients with CO-MRSA infections; controls (87) were patients with community-onset methicillin-sensitive S. aureus infections (CO-MSSA). Demographic and clinical data and exposures to possible risk factors during the last 24 months were collected with a structured telephone-administered questionnaire. Skin and soft tissue were the predominant sites of infection, both for cases (68%) and for controls (60%). A large proportion of cases (26%) and controls (38%) had an underlying skin disease. The majority of cases (76%) and controls (61%) had received antibiotics within the last 6 months, and 51% and 31%, respectively, had been hospitalized within the previous year. In a multivariate analysis, non-Danish origin, defined as being from or having parents from outside Denmark, was the only independent risk factor for CO-MRSA infection (OR 30.5, 95% CI 3.6-257.3). Prior hospitalization for >7 days within the previous 6 months tended to be associated with CO-MRSA infection (OR 5.7, 95% CI 0.9-36.4). The predominant MRSA clones found in this study were CC80 (26%), CC8 (24%) and CC5 (18%). Resistance to three or more antimicrobial drug classes was seen in 47% of CO-MRSA isolates. Panton-Valentine leukocidin was found in 47% of CO-MRSA isolates. Apart from a non-Danish origin, CO-MRSA shared the same risk factors as CO-MSSA, which makes control a challenge. SN - 1469-0691 UR - https://www.unboundmedicine.com/medline/citation/18752595/Methicillin_resistant_Staphylococcus_aureus:_risk_factors_associated_with_community_onset_infections_in_Denmark_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1198-743X(14)61004-1 DB - PRIME DP - Unbound Medicine ER -