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Periodic leg movements in RLS patients as compared to controls: Are there differences beyond the PLM index?
Sleep Med. 2009 May; 10(5):566-71.SM

Abstract

OBJECTIVE

To characterize periodic leg movements (PLM) and their association with sleep disturbances in drug-free patients with restless legs syndrome (RLS) and healthy subjects without sleep complaints.

METHODS

Polysomnographic recordings of 95 patients with idiopathic RLS and 31 age-matched controls were compared, and correlation analysis between sleep efficiency and PLM variables was performed. All patients and controls were free of medication for 10 days prior to polysomnography.

RESULTS

PLM measures revealed a significantly longer mean duration of single PLM during wakefulness and non rapid eye movement (NREM) sleep in RLS patients as compared to controls. PLM indices were higher in RLS patients than in controls during all sleep stages, but not during wakefulness and slow wave sleep. A significantly higher number of PLM sequences was found in RLS patients than in controls. In RLS patients decreased sleep efficiency was associated with a higher number and a shorter duration of PLM sequences.

CONCLUSIONS

The mean duration of single PLM might be an appropriate parameter to discriminate between healthy subjects with PLM and patients with RLS. High numbers of PLM sequences of short duration might be an indicator for the decreased sleep quality in RLS patients.

Authors+Show Affiliations

Technical University of Munich, Department of Psychiatry and Psychotherapy, D-81675 Munich, Germany. g.boehm@lzr.tum.deNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18753004

Citation

Boehm, Gwendolyn, et al. "Periodic Leg Movements in RLS Patients as Compared to Controls: Are There Differences Beyond the PLM Index?" Sleep Medicine, vol. 10, no. 5, 2009, pp. 566-71.
Boehm G, Wetter TC, Trenkwalder C. Periodic leg movements in RLS patients as compared to controls: Are there differences beyond the PLM index? Sleep Med. 2009;10(5):566-71.
Boehm, G., Wetter, T. C., & Trenkwalder, C. (2009). Periodic leg movements in RLS patients as compared to controls: Are there differences beyond the PLM index? Sleep Medicine, 10(5), 566-71. https://doi.org/10.1016/j.sleep.2008.04.009
Boehm G, Wetter TC, Trenkwalder C. Periodic Leg Movements in RLS Patients as Compared to Controls: Are There Differences Beyond the PLM Index. Sleep Med. 2009;10(5):566-71. PubMed PMID: 18753004.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Periodic leg movements in RLS patients as compared to controls: Are there differences beyond the PLM index? AU - Boehm,Gwendolyn, AU - Wetter,Thomas C, AU - Trenkwalder,Claudia, Y1 - 2008/08/26/ PY - 2008/01/03/received PY - 2008/04/07/revised PY - 2008/04/09/accepted PY - 2008/8/30/pubmed PY - 2009/8/21/medline PY - 2008/8/30/entrez SP - 566 EP - 71 JF - Sleep medicine JO - Sleep Med VL - 10 IS - 5 N2 - OBJECTIVE: To characterize periodic leg movements (PLM) and their association with sleep disturbances in drug-free patients with restless legs syndrome (RLS) and healthy subjects without sleep complaints. METHODS: Polysomnographic recordings of 95 patients with idiopathic RLS and 31 age-matched controls were compared, and correlation analysis between sleep efficiency and PLM variables was performed. All patients and controls were free of medication for 10 days prior to polysomnography. RESULTS: PLM measures revealed a significantly longer mean duration of single PLM during wakefulness and non rapid eye movement (NREM) sleep in RLS patients as compared to controls. PLM indices were higher in RLS patients than in controls during all sleep stages, but not during wakefulness and slow wave sleep. A significantly higher number of PLM sequences was found in RLS patients than in controls. In RLS patients decreased sleep efficiency was associated with a higher number and a shorter duration of PLM sequences. CONCLUSIONS: The mean duration of single PLM might be an appropriate parameter to discriminate between healthy subjects with PLM and patients with RLS. High numbers of PLM sequences of short duration might be an indicator for the decreased sleep quality in RLS patients. SN - 1389-9457 UR - https://www.unboundmedicine.com/medline/citation/18753004/Periodic_leg_movements_in_RLS_patients_as_compared_to_controls:_Are_there_differences_beyond_the_PLM_index L2 - https://linkinghub.elsevier.com/retrieve/pii/S1389-9457(08)00146-9 DB - PRIME DP - Unbound Medicine ER -