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Delta 9-tetrahydrocannabinol induces dopamine release in the human striatum.
Neuropsychopharmacology. 2009 Feb; 34(3):759-66.N

Abstract

The influence of cannabis on mental health receives growing scientific and political attention. An increasing demand for treatment of cannabis dependence has refueled the discussion about the addictive potential of cannabis. A key feature of all addictive drugs is the ability to increase synaptic dopamine levels in the striatum, a mechanism involved in their rewarding and motivating effects. However, it is currently unknown if cannabis can stimulate striatal dopamine neurotransmission in humans. Here we show that Delta 9-tetrahydrocannabinol (THC), the main psychoactive component in cannabis, induces dopamine release in the human striatum. Using the dopamine D(2)/D(3) receptor tracer [(11)C]raclopride and positron emission tomography in seven healthy subjects, we demonstrate that THC inhalation reduces [(11)C]raclopride binding in the ventral striatum and the precommissural dorsal putamen but not in other striatal subregions. This is consistent with an increase in dopamine levels in these regions. These results suggest that THC shares a potentially addictive property with other drugs of abuse. Further, it implies that the endogenous cannabinoid system is involved in regulating striatal dopamine release. This allows new directions in research on the effects of THC in neuropsychiatric disorders, such as schizophrenia.

Authors+Show Affiliations

Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands. M.Bossong@umcutrecht.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

18754005

Citation

Bossong, Matthijs G., et al. "Delta 9-tetrahydrocannabinol Induces Dopamine Release in the Human Striatum." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, vol. 34, no. 3, 2009, pp. 759-66.
Bossong MG, van Berckel BN, Boellaard R, et al. Delta 9-tetrahydrocannabinol induces dopamine release in the human striatum. Neuropsychopharmacology. 2009;34(3):759-66.
Bossong, M. G., van Berckel, B. N., Boellaard, R., Zuurman, L., Schuit, R. C., Windhorst, A. D., van Gerven, J. M., Ramsey, N. F., Lammertsma, A. A., & Kahn, R. S. (2009). Delta 9-tetrahydrocannabinol induces dopamine release in the human striatum. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 34(3), 759-66. https://doi.org/10.1038/npp.2008.138
Bossong MG, et al. Delta 9-tetrahydrocannabinol Induces Dopamine Release in the Human Striatum. Neuropsychopharmacology. 2009;34(3):759-66. PubMed PMID: 18754005.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Delta 9-tetrahydrocannabinol induces dopamine release in the human striatum. AU - Bossong,Matthijs G, AU - van Berckel,Bart N M, AU - Boellaard,Ronald, AU - Zuurman,Lineke, AU - Schuit,Robert C, AU - Windhorst,Albert D, AU - van Gerven,Joop M A, AU - Ramsey,Nick F, AU - Lammertsma,Adriaan A, AU - Kahn,René S, Y1 - 2008/08/27/ PY - 2008/8/30/pubmed PY - 2009/3/31/medline PY - 2008/8/30/entrez SP - 759 EP - 66 JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology JO - Neuropsychopharmacology VL - 34 IS - 3 N2 - The influence of cannabis on mental health receives growing scientific and political attention. An increasing demand for treatment of cannabis dependence has refueled the discussion about the addictive potential of cannabis. A key feature of all addictive drugs is the ability to increase synaptic dopamine levels in the striatum, a mechanism involved in their rewarding and motivating effects. However, it is currently unknown if cannabis can stimulate striatal dopamine neurotransmission in humans. Here we show that Delta 9-tetrahydrocannabinol (THC), the main psychoactive component in cannabis, induces dopamine release in the human striatum. Using the dopamine D(2)/D(3) receptor tracer [(11)C]raclopride and positron emission tomography in seven healthy subjects, we demonstrate that THC inhalation reduces [(11)C]raclopride binding in the ventral striatum and the precommissural dorsal putamen but not in other striatal subregions. This is consistent with an increase in dopamine levels in these regions. These results suggest that THC shares a potentially addictive property with other drugs of abuse. Further, it implies that the endogenous cannabinoid system is involved in regulating striatal dopamine release. This allows new directions in research on the effects of THC in neuropsychiatric disorders, such as schizophrenia. SN - 1740-634X UR - https://www.unboundmedicine.com/medline/citation/18754005/Delta_9_tetrahydrocannabinol_induces_dopamine_release_in_the_human_striatum_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:18754005 DB - PRIME DP - Unbound Medicine ER -