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Optimization of ibuprofen gel formulations using experimental design technique for enhanced transdermal penetration.
Int J Pharm. 2008 Nov 19; 364(1):14-20.IJ

Abstract

The aims of this study were to develop a transdermal gel formulation for ibuprofen using experimental design techniques and to evaluate its pharmacokinetic properties. The three factors chosen for factorial design were the concentrations of drug, polyoxyethylene(5)cetyl/oleyl ether and ethanol and the levels of each factor were low, medium and high. Skin permeation rates and lag times of ibuprofen were evaluated using the Franz-type diffusion cell in order to optimize the gel formulation. The permeation rate of ibuprofen significantly increased in proportion to the drug concentration, but significantly decreased in proportion to POE(5)cetyl/oleyl ether concentration. Ethanol concentration was inversely proportional to the lag time. The pharmacokinetic properties of the optimized formulation were compared with those of two marketed products in rats. The relative bioavailability of ibuprofen gel compared to the two marketed products was 228.8% and 181.0%. In conclusion, a transdermal ibuprofen gel was formulated successfully using the technique of experimental design and these results helped in finding the optimum formulation for transdermal drug release.

Authors+Show Affiliations

College of Pharmacy, Sungkyunkwan University, 300 Cheoncheon-dong, Jangan-gu, Suwon, Gyeonggi-do 440-746, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18755258

Citation

Rhee, Yun-Seok, et al. "Optimization of Ibuprofen Gel Formulations Using Experimental Design Technique for Enhanced Transdermal Penetration." International Journal of Pharmaceutics, vol. 364, no. 1, 2008, pp. 14-20.
Rhee YS, Chang SY, Park CW, et al. Optimization of ibuprofen gel formulations using experimental design technique for enhanced transdermal penetration. Int J Pharm. 2008;364(1):14-20.
Rhee, Y. S., Chang, S. Y., Park, C. W., Chi, S. C., & Park, E. S. (2008). Optimization of ibuprofen gel formulations using experimental design technique for enhanced transdermal penetration. International Journal of Pharmaceutics, 364(1), 14-20. https://doi.org/10.1016/j.ijpharm.2008.07.029
Rhee YS, et al. Optimization of Ibuprofen Gel Formulations Using Experimental Design Technique for Enhanced Transdermal Penetration. Int J Pharm. 2008 Nov 19;364(1):14-20. PubMed PMID: 18755258.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Optimization of ibuprofen gel formulations using experimental design technique for enhanced transdermal penetration. AU - Rhee,Yun-Seok, AU - Chang,Si-Young, AU - Park,Chun-Woong, AU - Chi,Sang-Cheol, AU - Park,Eun-Seok, Y1 - 2008/08/06/ PY - 2007/11/26/received PY - 2008/07/21/revised PY - 2008/07/23/accepted PY - 2008/8/30/pubmed PY - 2009/2/4/medline PY - 2008/8/30/entrez SP - 14 EP - 20 JF - International journal of pharmaceutics JO - Int J Pharm VL - 364 IS - 1 N2 - The aims of this study were to develop a transdermal gel formulation for ibuprofen using experimental design techniques and to evaluate its pharmacokinetic properties. The three factors chosen for factorial design were the concentrations of drug, polyoxyethylene(5)cetyl/oleyl ether and ethanol and the levels of each factor were low, medium and high. Skin permeation rates and lag times of ibuprofen were evaluated using the Franz-type diffusion cell in order to optimize the gel formulation. The permeation rate of ibuprofen significantly increased in proportion to the drug concentration, but significantly decreased in proportion to POE(5)cetyl/oleyl ether concentration. Ethanol concentration was inversely proportional to the lag time. The pharmacokinetic properties of the optimized formulation were compared with those of two marketed products in rats. The relative bioavailability of ibuprofen gel compared to the two marketed products was 228.8% and 181.0%. In conclusion, a transdermal ibuprofen gel was formulated successfully using the technique of experimental design and these results helped in finding the optimum formulation for transdermal drug release. SN - 0378-5173 UR - https://www.unboundmedicine.com/medline/citation/18755258/Optimization_of_ibuprofen_gel_formulations_using_experimental_design_technique_for_enhanced_transdermal_penetration_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(08)00530-9 DB - PRIME DP - Unbound Medicine ER -