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[A hyperpolarization-activated current in rat menthol-sensitive sensory neurons].
Fiziol Zh. 2008; 54(4):16-22.FZ

Abstract

In the present study we have investigated the correlation between hyperpolarization-activated current (1(h)) and menthol-activated current (I(TRPM8)) in rat dorsal root ganglion (DRG) neurons. We showed that I(h) is present in 89% of menthol-sensitive neurons which makes its presence reliable, though not absolute, criterion for pre-selection of such neurons. Endogenous I(h) recorded from different neurons exhibited variable density and activation kinetics. Based on the analysis of I(h) activation kinetics we hypothesize that the population of hyperpolarization-activated channels in menthol-sensitive DRG neurons is mainly represented by HCN1, HCN2 and HCN3 channels. The expression of HCN4 isoform in these cells is very low.

Authors

Kondrats'kyĭ AP
No affiliation info available
Kondrats'ka KO
No affiliation info available
Sotkis HV
No affiliation info available
Naĭd'onov VH
No affiliation info available
Shuba IaM
No affiliation info available

MeSH

AnimalsCells, CulturedCold TemperatureCyclic Nucleotide-Gated Cation ChannelsElectrophysiologyGanglia, SpinalHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsMentholNeurons, AfferentPotassium ChannelsRatsTRPM Cation Channels

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

ukr

PubMed ID

18756770

Citation

Kondrats'kyĭ, A P., et al. "[A Hyperpolarization-activated Current in Rat Menthol-sensitive Sensory Neurons]." Fiziolohichnyi Zhurnal (Kiev, Ukraine : 1994), vol. 54, no. 4, 2008, pp. 16-22.
Kondrats'kyĭ AP, Kondrats'ka KO, Sotkis HV, et al. [A hyperpolarization-activated current in rat menthol-sensitive sensory neurons]. Fiziol Zh. 2008;54(4):16-22.
Kondrats'kyĭ, A. P., Kondrats'ka, K. O., Sotkis, H. V., Naĭd'onov, V. H., & Shuba, I. a. M. (2008). [A hyperpolarization-activated current in rat menthol-sensitive sensory neurons]. Fiziolohichnyi Zhurnal (Kiev, Ukraine : 1994), 54(4), 16-22.
Kondrats'kyĭ AP, et al. [A Hyperpolarization-activated Current in Rat Menthol-sensitive Sensory Neurons]. Fiziol Zh. 2008;54(4):16-22. PubMed PMID: 18756770.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [A hyperpolarization-activated current in rat menthol-sensitive sensory neurons]. AU - Kondrats'kyĭ,A P, AU - Kondrats'ka,K O, AU - Sotkis,H V, AU - Naĭd'onov,V H, AU - Shuba,Ia M, PY - 2008/9/2/pubmed PY - 2008/10/22/medline PY - 2008/9/2/entrez SP - 16 EP - 22 JF - Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) JO - Fiziol Zh VL - 54 IS - 4 N2 - In the present study we have investigated the correlation between hyperpolarization-activated current (1(h)) and menthol-activated current (I(TRPM8)) in rat dorsal root ganglion (DRG) neurons. We showed that I(h) is present in 89% of menthol-sensitive neurons which makes its presence reliable, though not absolute, criterion for pre-selection of such neurons. Endogenous I(h) recorded from different neurons exhibited variable density and activation kinetics. Based on the analysis of I(h) activation kinetics we hypothesize that the population of hyperpolarization-activated channels in menthol-sensitive DRG neurons is mainly represented by HCN1, HCN2 and HCN3 channels. The expression of HCN4 isoform in these cells is very low. SN - 2522-9028 UR - https://www.unboundmedicine.com/medline/citation/18756770/[A_hyperpolarization_activated_current_in_rat_menthol_sensitive_sensory_neurons]_ DB - PRIME DP - Unbound Medicine ER -