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[Effect of semax on the temporary dynamics of brain-derived neurotrophic factor and nerve growth factor gene expression in the rat hippocampus and frontal cortex].
Mol Gen Mikrobiol Virusol. 2008MG

Abstract

Semax is a synthetic peptide, which consists of the N-terminal adrenocorticotropic hormone fragment (4-7) (ACTH4-7) and C-terminal Pro-Gly-Pro peptide. Semax promotes neuron survival in hypoxia, increases selective attention and memory storage. It was shown that this synthetic peptide exerted a number of gene expressions, especially brain derived neurotrophic factor gene (Bdnf) and nerve growth factor gene (Ngf). Temporary dynamics of Bdnf and Ngf ex- pression in rat hippocampus and frontal cortex under Semax action (50 mg/kg, single intranasal administration) was studied in this work. It was shown that the studied gene expression levels changed significantly both in the hippocampus and the frontal cortex tissues 20 minutes after the peptide preparation application. The expression levels decreased in the hippocampus and increased in the frontal cortex. Forty minutes after Semax administration both gene expression levels returned to the level typical of control tissues. After that they increased significantly by 90 minutes after experiment start. Bdnf and Ngf expression levels decreased up to the control levels by 8 hours after medicine applying maximum gene expression levels were attained. Thus, Semax administration results in rapid, long-term, and specific activation of Bdnf and Ngf expression changes in different rat brain departments.

Authors

Agapova TIu
No affiliation info available
Agniullin IaV
No affiliation info available
Silachev DN
No affiliation info available
Shadrina MI
No affiliation info available
Slominskiĭ PA
No affiliation info available
Shram SI
No affiliation info available
Limborskaia SA
No affiliation info available
Miasoedov NF
No affiliation info available

MeSH

Adrenocorticotropic HormoneAnimalsBrain-Derived Neurotrophic FactorCerebral CortexGene ExpressionHippocampusMaleNerve Growth FactorsNeuroprotective AgentsPeptide FragmentsRatsRats, Wistar

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

rus

PubMed ID

18756821

Citation

Agapova, T Iu, et al. "[Effect of Semax On the Temporary Dynamics of Brain-derived Neurotrophic Factor and Nerve Growth Factor Gene Expression in the Rat Hippocampus and Frontal Cortex]." Molekuliarnaia Genetika, Mikrobiologiia I Virusologiia, 2008, pp. 28-32.
Agapova TIu, Agniullin IaV, Silachev DN, et al. [Effect of semax on the temporary dynamics of brain-derived neurotrophic factor and nerve growth factor gene expression in the rat hippocampus and frontal cortex]. Mol Gen Mikrobiol Virusol. 2008.
Agapova, T. I. u., Agniullin, I. a. V., Silachev, D. N., Shadrina, M. I., Slominskiĭ, P. A., Shram, S. I., Limborskaia, S. A., & Miasoedov, N. F. (2008). [Effect of semax on the temporary dynamics of brain-derived neurotrophic factor and nerve growth factor gene expression in the rat hippocampus and frontal cortex]. Molekuliarnaia Genetika, Mikrobiologiia I Virusologiia, (3), 28-32.
Agapova TIu, et al. [Effect of Semax On the Temporary Dynamics of Brain-derived Neurotrophic Factor and Nerve Growth Factor Gene Expression in the Rat Hippocampus and Frontal Cortex]. Mol Gen Mikrobiol Virusol. 2008;(3)28-32. PubMed PMID: 18756821.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of semax on the temporary dynamics of brain-derived neurotrophic factor and nerve growth factor gene expression in the rat hippocampus and frontal cortex]. AU - Agapova,T Iu, AU - Agniullin,Ia V, AU - Silachev,D N, AU - Shadrina,M I, AU - Slominskiĭ,P A, AU - Shram,S I, AU - Limborskaia,S A, AU - Miasoedov,N F, PY - 2008/9/2/pubmed PY - 2008/10/11/medline PY - 2008/9/2/entrez SP - 28 EP - 32 JF - Molekuliarnaia genetika, mikrobiologiia i virusologiia JO - Mol Gen Mikrobiol Virusol IS - 3 N2 - Semax is a synthetic peptide, which consists of the N-terminal adrenocorticotropic hormone fragment (4-7) (ACTH4-7) and C-terminal Pro-Gly-Pro peptide. Semax promotes neuron survival in hypoxia, increases selective attention and memory storage. It was shown that this synthetic peptide exerted a number of gene expressions, especially brain derived neurotrophic factor gene (Bdnf) and nerve growth factor gene (Ngf). Temporary dynamics of Bdnf and Ngf ex- pression in rat hippocampus and frontal cortex under Semax action (50 mg/kg, single intranasal administration) was studied in this work. It was shown that the studied gene expression levels changed significantly both in the hippocampus and the frontal cortex tissues 20 minutes after the peptide preparation application. The expression levels decreased in the hippocampus and increased in the frontal cortex. Forty minutes after Semax administration both gene expression levels returned to the level typical of control tissues. After that they increased significantly by 90 minutes after experiment start. Bdnf and Ngf expression levels decreased up to the control levels by 8 hours after medicine applying maximum gene expression levels were attained. Thus, Semax administration results in rapid, long-term, and specific activation of Bdnf and Ngf expression changes in different rat brain departments. SN - 0208-0613 UR - https://www.unboundmedicine.com/medline/citation/18756821/[Effect_of_semax_on_the_temporary_dynamics_of_brain_derived_neurotrophic_factor_and_nerve_growth_factor_gene_expression_in_the_rat_hippocampus_and_frontal_cortex]_ L2 - http://amigo.geneontology.org/amigo/reference/PMID:18756821 DB - PRIME DP - Unbound Medicine ER -