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Local blockade of TSLP receptor alleviated allergic disease by regulating airway dendritic cells.
Clin Immunol. 2008 Nov; 129(2):202-10.CI

Abstract

Thymic stromal lymphopoietin (TSLP) emerges as a central mediator of T helper cell (Th)2-dominant allergic diseases. However, the role of TSLP receptor (TSLPR) in allergen-induced Th2 priming, and the effects of TSLP signaling blocking on the development of asthma remain unclear. Here we showed that allergen challenge caused a rapid accumulation of TSLP in the airways of asthmatic mice, correlating well with eosinophils counts and interleukin (IL)-5 productions. When TSLP signaling was blocked by intratracheal administration of anti-TSLPR antibody before sensitization, eosinophilic airway inflammation, goblet cell hyperplasia and Th2 cytokines productions were significantly reduced. The alleviating effects of TSLPR blocking were achieved by inhibition of maturation and migration of airway dendritic cells (DCs), as well as their abilities of initiating CD4+T cell responses. Thus, local application of anti-TSLPR prevented Th2-mediated airway inflammation, at least partly, by regulating DCs function, which might be exploited to develop novel treatments for asthma.

Authors+Show Affiliations

Department of Immunology, Hangzhou Normal University, Hangzhou, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18757241

Citation

Shi, Liyun, et al. "Local Blockade of TSLP Receptor Alleviated Allergic Disease By Regulating Airway Dendritic Cells." Clinical Immunology (Orlando, Fla.), vol. 129, no. 2, 2008, pp. 202-10.
Shi L, Leu SW, Xu F, et al. Local blockade of TSLP receptor alleviated allergic disease by regulating airway dendritic cells. Clin Immunol. 2008;129(2):202-10.
Shi, L., Leu, S. W., Xu, F., Zhou, X., Yin, H., Cai, L., & Zhang, L. (2008). Local blockade of TSLP receptor alleviated allergic disease by regulating airway dendritic cells. Clinical Immunology (Orlando, Fla.), 129(2), 202-10. https://doi.org/10.1016/j.clim.2008.07.015
Shi L, et al. Local Blockade of TSLP Receptor Alleviated Allergic Disease By Regulating Airway Dendritic Cells. Clin Immunol. 2008;129(2):202-10. PubMed PMID: 18757241.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Local blockade of TSLP receptor alleviated allergic disease by regulating airway dendritic cells. AU - Shi,Liyun, AU - Leu,Shaw-Wei, AU - Xu,Feng, AU - Zhou,Xielai, AU - Yin,Hongping, AU - Cai,Lingfei, AU - Zhang,Lihuang, Y1 - 2008/08/30/ PY - 2008/03/06/received PY - 2008/06/22/revised PY - 2008/07/02/accepted PY - 2008/9/2/pubmed PY - 2008/11/7/medline PY - 2008/9/2/entrez SP - 202 EP - 10 JF - Clinical immunology (Orlando, Fla.) JO - Clin. Immunol. VL - 129 IS - 2 N2 - Thymic stromal lymphopoietin (TSLP) emerges as a central mediator of T helper cell (Th)2-dominant allergic diseases. However, the role of TSLP receptor (TSLPR) in allergen-induced Th2 priming, and the effects of TSLP signaling blocking on the development of asthma remain unclear. Here we showed that allergen challenge caused a rapid accumulation of TSLP in the airways of asthmatic mice, correlating well with eosinophils counts and interleukin (IL)-5 productions. When TSLP signaling was blocked by intratracheal administration of anti-TSLPR antibody before sensitization, eosinophilic airway inflammation, goblet cell hyperplasia and Th2 cytokines productions were significantly reduced. The alleviating effects of TSLPR blocking were achieved by inhibition of maturation and migration of airway dendritic cells (DCs), as well as their abilities of initiating CD4+T cell responses. Thus, local application of anti-TSLPR prevented Th2-mediated airway inflammation, at least partly, by regulating DCs function, which might be exploited to develop novel treatments for asthma. SN - 1521-7035 UR - https://www.unboundmedicine.com/medline/citation/18757241/Local_blockade_of_TSLP_receptor_alleviated_allergic_disease_by_regulating_airway_dendritic_cells_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1521-6616(08)00715-8 DB - PRIME DP - Unbound Medicine ER -