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Importance of lack of interest in patients with mild cognitive impairment.
Am J Geriatr Psychiatry. 2008 Sep; 16(9):770-6.AJ

Abstract

OBJECTIVE

Apathy is one of the most common behavioral symptoms in mild cognitive impairment (MCI). The aim of the authors' study was to examine the influence of the apathy dimensions, i.e., emotional blunting, lack of initiative, and lack of interest, on the risk of developing of Alzheimer disease (AD) in patients with MCI.

DESIGN

Longitudinal study.

SETTING

Fourteen French memory clinics.

PARTICIPANTS

Apathy was assessed in 214 MCI patients. The main endpoint considered was the development of AD during the 3-year follow-up.

MEASUREMENTS

The neuropsychiatric evaluation included the Goldberg anxiety scale and the Montgomery and Asberg Depression Rating Scale; apathy was assessed with the Apathy Inventory.

RESULTS

After 3 years, 59 patients (27.2%) had developed AD. The risk of conversion to AD was significantly higher for patients with lack of interest. Using Cox analyses, controlling for age, gender and education, the difference between survival curves was significant for lack of interest.

CONCLUSIONS

Lack of interest, a mild behavioral sign, could be an indicator of potential decline in MCI patients and underlines the importance of checking the cognitive status of these patients.

Authors+Show Affiliations

Centre Mémoire de Ressources et de Recherche, CHU de Nice, INSERM JE 2441, Nice, France. phil.robert15@orange.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18757769

Citation

Robert, Philippe H., et al. "Importance of Lack of Interest in Patients With Mild Cognitive Impairment." The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry, vol. 16, no. 9, 2008, pp. 770-6.
Robert PH, Berr C, Volteau M, et al. Importance of lack of interest in patients with mild cognitive impairment. Am J Geriatr Psychiatry. 2008;16(9):770-6.
Robert, P. H., Berr, C., Volteau, M., Bertogliati-Fileau, C., Benoit, M., Guerin, O., Sarazin, M., Legrain, S., & Dubois, B. (2008). Importance of lack of interest in patients with mild cognitive impairment. The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry, 16(9), 770-6. https://doi.org/10.1097/JGP.0b013e31817e73db
Robert PH, et al. Importance of Lack of Interest in Patients With Mild Cognitive Impairment. Am J Geriatr Psychiatry. 2008;16(9):770-6. PubMed PMID: 18757769.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Importance of lack of interest in patients with mild cognitive impairment. AU - Robert,Philippe H, AU - Berr,Claudine, AU - Volteau,Magali, AU - Bertogliati-Fileau,Christelle, AU - Benoit,Michel, AU - Guerin,Olivier, AU - Sarazin,Marie, AU - Legrain,Sylvie, AU - Dubois,Bruno, AU - ,, PY - 2008/9/2/pubmed PY - 2009/3/5/medline PY - 2008/9/2/entrez SP - 770 EP - 6 JF - The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry JO - Am J Geriatr Psychiatry VL - 16 IS - 9 N2 - OBJECTIVE: Apathy is one of the most common behavioral symptoms in mild cognitive impairment (MCI). The aim of the authors' study was to examine the influence of the apathy dimensions, i.e., emotional blunting, lack of initiative, and lack of interest, on the risk of developing of Alzheimer disease (AD) in patients with MCI. DESIGN: Longitudinal study. SETTING: Fourteen French memory clinics. PARTICIPANTS: Apathy was assessed in 214 MCI patients. The main endpoint considered was the development of AD during the 3-year follow-up. MEASUREMENTS: The neuropsychiatric evaluation included the Goldberg anxiety scale and the Montgomery and Asberg Depression Rating Scale; apathy was assessed with the Apathy Inventory. RESULTS: After 3 years, 59 patients (27.2%) had developed AD. The risk of conversion to AD was significantly higher for patients with lack of interest. Using Cox analyses, controlling for age, gender and education, the difference between survival curves was significant for lack of interest. CONCLUSIONS: Lack of interest, a mild behavioral sign, could be an indicator of potential decline in MCI patients and underlines the importance of checking the cognitive status of these patients. SN - 1545-7214 UR - https://www.unboundmedicine.com/medline/citation/18757769/Importance_of_lack_of_interest_in_patients_with_mild_cognitive_impairment_ L2 - https://linkinghub.elsevier.com/retrieve/pii/16/9/770 DB - PRIME DP - Unbound Medicine ER -