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Duration of untreated psychosis and social function: 1-year follow-up study of first-episode schizophrenia.
Br J Psychiatry. 2008 Sep; 193(3):203-9.BJ

Abstract

BACKGROUND

In first-episode schizophrenia, longer duration of untreated psychosis (DUP) predicts poorer outcomes.

AIMS

To address whether the relationship between DUP and outcome is a direct causal one or the result of association between symptoms and/or cognitive functioning and social functioning at the same time point.

METHOD

Symptoms, social function and cognitive function were assessed in 98 patients with first-episode schizphrenia at presentation and 1 year later.

RESULTS

There was no significant clinical difference between participants with short and long DUP at presentation. Linear regression analyses revealed that longer DUP significantly predicted more severe positive and negative symptoms and poorer social function at 1 year, independent of scores at presentation. Path analyses revealed independent direct relationships between DUP and social function, core negative symptoms and positive symptoms. There was no significant association between DUP and cognition.

CONCLUSIONS

Longer DUP predicts poor social function independently of symptoms. The findings underline the importance of taking account of the phenomenological overlap between measures of negative symptoms and social function when investigating the effects of DUP.

Authors+Show Affiliations

Department of Psychological Medicine, Imperial College Faculty of Medicine, St Dunstan's Road, London W6 8RF, UK. t.r.barnes@imperial.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18757977

Citation

Barnes, Thomas R E., et al. "Duration of Untreated Psychosis and Social Function: 1-year Follow-up Study of First-episode Schizophrenia." The British Journal of Psychiatry : the Journal of Mental Science, vol. 193, no. 3, 2008, pp. 203-9.
Barnes TR, Leeson VC, Mutsatsa SH, et al. Duration of untreated psychosis and social function: 1-year follow-up study of first-episode schizophrenia. Br J Psychiatry. 2008;193(3):203-9.
Barnes, T. R., Leeson, V. C., Mutsatsa, S. H., Watt, H. C., Hutton, S. B., & Joyce, E. M. (2008). Duration of untreated psychosis and social function: 1-year follow-up study of first-episode schizophrenia. The British Journal of Psychiatry : the Journal of Mental Science, 193(3), 203-9. https://doi.org/10.1192/bjp.bp.108.049718
Barnes TR, et al. Duration of Untreated Psychosis and Social Function: 1-year Follow-up Study of First-episode Schizophrenia. Br J Psychiatry. 2008;193(3):203-9. PubMed PMID: 18757977.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Duration of untreated psychosis and social function: 1-year follow-up study of first-episode schizophrenia. AU - Barnes,Thomas R E, AU - Leeson,Verity C, AU - Mutsatsa,Stanley H, AU - Watt,Hilary C, AU - Hutton,Sam B, AU - Joyce,Eileen M, PY - 2008/9/2/pubmed PY - 2009/1/23/medline PY - 2008/9/2/entrez SP - 203 EP - 9 JF - The British journal of psychiatry : the journal of mental science JO - Br J Psychiatry VL - 193 IS - 3 N2 - BACKGROUND: In first-episode schizophrenia, longer duration of untreated psychosis (DUP) predicts poorer outcomes. AIMS: To address whether the relationship between DUP and outcome is a direct causal one or the result of association between symptoms and/or cognitive functioning and social functioning at the same time point. METHOD: Symptoms, social function and cognitive function were assessed in 98 patients with first-episode schizphrenia at presentation and 1 year later. RESULTS: There was no significant clinical difference between participants with short and long DUP at presentation. Linear regression analyses revealed that longer DUP significantly predicted more severe positive and negative symptoms and poorer social function at 1 year, independent of scores at presentation. Path analyses revealed independent direct relationships between DUP and social function, core negative symptoms and positive symptoms. There was no significant association between DUP and cognition. CONCLUSIONS: Longer DUP predicts poor social function independently of symptoms. The findings underline the importance of taking account of the phenomenological overlap between measures of negative symptoms and social function when investigating the effects of DUP. SN - 0007-1250 UR - https://www.unboundmedicine.com/medline/citation/18757977/Duration_of_untreated_psychosis_and_social_function:_1_year_follow_up_study_of_first_episode_schizophrenia_ L2 - https://www.cambridge.org/core/product/identifier/S0007125000235873/type/journal_article DB - PRIME DP - Unbound Medicine ER -