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[Mechanism underlying osteoarthritis induced by mechanical stress on joint cartilage].
Clin Calcium. 2008 Sep; 18(9):1278-86.CC

Abstract

Osteoarthritis (OA) , one of the most common skeletal disorders characterized by cartilage degradation and osteophyte formation in joints, is induced by accumulated mechanical stress ; however, little is known about the underlying molecular mechanism. Several experimental OA models in mice by producing instability in the knee joints have been developed to apply approaches from mouse genetics. Our mouse genetic approaches found that the induction of a transcriptional activator Runx2 in chondrocytes under mechanical stress contributes to the pathogenesis of OA through chondrocyte hypertrophy. In addition, chondrocyte apoptosis has recently been identified as being involved in OA progression. We hereby propose that these endochondral ossification signals may be important for the OA progression, suggesting that the related molecules can clinically be therapeutic targets of this disease.

Authors+Show Affiliations

The University of Tokyo, Graduate School of Medicine, Department of Orthopaedic Surgery.

Pub Type(s)

English Abstract
Journal Article
Review

Language

jpn

PubMed ID

18758033

Citation

Kawaguchi, Hiroshi. "[Mechanism Underlying Osteoarthritis Induced By Mechanical Stress On Joint Cartilage]." Clinical Calcium, vol. 18, no. 9, 2008, pp. 1278-86.
Kawaguchi H. [Mechanism underlying osteoarthritis induced by mechanical stress on joint cartilage]. Clin Calcium. 2008;18(9):1278-86.
Kawaguchi, H. (2008). [Mechanism underlying osteoarthritis induced by mechanical stress on joint cartilage]. Clinical Calcium, 18(9), 1278-86. https://doi.org/CliCa080912781286
Kawaguchi H. [Mechanism Underlying Osteoarthritis Induced By Mechanical Stress On Joint Cartilage]. Clin Calcium. 2008;18(9):1278-86. PubMed PMID: 18758033.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Mechanism underlying osteoarthritis induced by mechanical stress on joint cartilage]. A1 - Kawaguchi,Hiroshi, PY - 2008/9/2/pubmed PY - 2008/10/25/medline PY - 2008/9/2/entrez SP - 1278 EP - 86 JF - Clinical calcium JO - Clin Calcium VL - 18 IS - 9 N2 - Osteoarthritis (OA) , one of the most common skeletal disorders characterized by cartilage degradation and osteophyte formation in joints, is induced by accumulated mechanical stress ; however, little is known about the underlying molecular mechanism. Several experimental OA models in mice by producing instability in the knee joints have been developed to apply approaches from mouse genetics. Our mouse genetic approaches found that the induction of a transcriptional activator Runx2 in chondrocytes under mechanical stress contributes to the pathogenesis of OA through chondrocyte hypertrophy. In addition, chondrocyte apoptosis has recently been identified as being involved in OA progression. We hereby propose that these endochondral ossification signals may be important for the OA progression, suggesting that the related molecules can clinically be therapeutic targets of this disease. SN - 0917-5857 UR - https://www.unboundmedicine.com/medline/citation/18758033/[Mechanism_underlying_osteoarthritis_induced_by_mechanical_stress_on_joint_cartilage]_ L2 - https://medlineplus.gov/osteoarthritis.html DB - PRIME DP - Unbound Medicine ER -