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Anti-inflammatory activities of ethanolic extract of Carica papaya leaves.
Inflammopharmacology. 2008 Aug; 16(4):168-73.I

Abstract

The anti-inflammatory activity of an ethanolic extract of Carica papaya leaves was investigated in rats using carrageenan induced paw oedema, cotton pellet granuloma and formaldehyde induced arthritis models. Experimental animals received 25-200 mg/Kg (orally) of the extracts or saline (control group) and the reference group received 5 mg/ Kg of indomethacin. The ulcerogenic activity of the extract was also investigated. The results show that the extracts significantly (p <0.05) reduced paw oedema in the carrageenan test. Likewise the extract produced significant reduction in the amount of granuloma formed from 0.58 +/-0.07 to 0.22 +/-0.03 g. In the formaldehyde arthritis model, the extracts significantly reduced the persistent oedema from the 4th day to the 10th day of the investigation. The extracts also produced slight mucosal irritation at high doses. The study establishes the anti-inflammatory activity of Carica papaya leaves.

Authors+Show Affiliations

Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, P. M. B. 1515, Ilorin, Nigeria. deleyele@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

18759075

Citation

Owoyele, Bamidele V., et al. "Anti-inflammatory Activities of Ethanolic Extract of Carica Papaya Leaves." Inflammopharmacology, vol. 16, no. 4, 2008, pp. 168-73.
Owoyele BV, Adebukola OM, Funmilayo AA, et al. Anti-inflammatory activities of ethanolic extract of Carica papaya leaves. Inflammopharmacology. 2008;16(4):168-73.
Owoyele, B. V., Adebukola, O. M., Funmilayo, A. A., & Soladoye, A. O. (2008). Anti-inflammatory activities of ethanolic extract of Carica papaya leaves. Inflammopharmacology, 16(4), 168-73. https://doi.org/10.1007/s10787-008-7008-0
Owoyele BV, et al. Anti-inflammatory Activities of Ethanolic Extract of Carica Papaya Leaves. Inflammopharmacology. 2008;16(4):168-73. PubMed PMID: 18759075.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory activities of ethanolic extract of Carica papaya leaves. AU - Owoyele,Bamidele V, AU - Adebukola,Olubori M, AU - Funmilayo,Adeoye A, AU - Soladoye,Ayodele O, PY - 2008/9/2/pubmed PY - 2008/10/11/medline PY - 2008/9/2/entrez SP - 168 EP - 73 JF - Inflammopharmacology JO - Inflammopharmacology VL - 16 IS - 4 N2 - The anti-inflammatory activity of an ethanolic extract of Carica papaya leaves was investigated in rats using carrageenan induced paw oedema, cotton pellet granuloma and formaldehyde induced arthritis models. Experimental animals received 25-200 mg/Kg (orally) of the extracts or saline (control group) and the reference group received 5 mg/ Kg of indomethacin. The ulcerogenic activity of the extract was also investigated. The results show that the extracts significantly (p <0.05) reduced paw oedema in the carrageenan test. Likewise the extract produced significant reduction in the amount of granuloma formed from 0.58 +/-0.07 to 0.22 +/-0.03 g. In the formaldehyde arthritis model, the extracts significantly reduced the persistent oedema from the 4th day to the 10th day of the investigation. The extracts also produced slight mucosal irritation at high doses. The study establishes the anti-inflammatory activity of Carica papaya leaves. SN - 0925-4692 UR - https://www.unboundmedicine.com/medline/citation/18759075/Anti_inflammatory_activities_of_ethanolic_extract_of_Carica_papaya_leaves_ L2 - https://dx.doi.org/10.1007/s10787-008-7008-0 DB - PRIME DP - Unbound Medicine ER -