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[The value of duodenal biopsy within routine upper endoscopy: a prospective study in 1000 patients].
Z Gastroenterol. 2008 Aug; 46(8):771-5.ZG

Abstract

BACKGROUND AND AIM

Several gastrointestinal diseases are localised in the small bowel and are confirmed by duodenal biopsies upon upper gastrointestinal endoscopy. However, the clinical value of routine duodenal biopsies during endoscopy has not been satisfactorily defined and was assessed in the current study.

METHODS

In 1000 consecutive patients duodenal biopsies were performed during routine upper gastrointestinal endoscopy. Endoscopic diagnoses, symptoms and the prevalence of anaemia were correlated with the histological diagnoses.

RESULTS

Coeliac disease and giardiasis was diagnosed in 18 and two patients, respectively (2.0 % of all cases). In 11 (55 %) patients the diagnosis was already made macroscopically during endoscopy. The sensitivity for endoscopic diagnosis of coeliac disease MARSH III was 84.6 %. There was no correlation between clinical symptoms, the prevalence of anaemia and the diagnosis of coeliac disease or giardiasis in our cohort.

CONCLUSION

Endoscopic diagnosis of advanced celiac disease (MARSH III) can be made with high sensitivity and specifity. Nevertheless, duodenal biopsy is necessary for the diagnosis of early coeliac disease or giardiasis. However, the routine duodenal sampling of normal mucosa during gastrointestinal endoscopy cannot be recommended.

Authors+Show Affiliations

Medizinische Klinik III, Universitätsklinikum Aachen (RWTH). Jenstischendorf@freenet.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

18759200

Citation

Tischendorf, J J W., et al. "[The Value of Duodenal Biopsy Within Routine Upper Endoscopy: a Prospective Study in 1000 Patients]." Zeitschrift Fur Gastroenterologie, vol. 46, no. 8, 2008, pp. 771-5.
Tischendorf JJ, Wopp K, Streetz KL, et al. [The value of duodenal biopsy within routine upper endoscopy: a prospective study in 1000 patients]. Z Gastroenterol. 2008;46(8):771-5.
Tischendorf, J. J., Wopp, K., Streetz, K. L., Bach, J., Meyer, M., Tischendorf, S., Gassler, N., Koch, A., Geier, A., Wasmuth, H. E., Trautwein, C., & Winograd, R. (2008). [The value of duodenal biopsy within routine upper endoscopy: a prospective study in 1000 patients]. Zeitschrift Fur Gastroenterologie, 46(8), 771-5. https://doi.org/10.1055/s-2008-1027407
Tischendorf JJ, et al. [The Value of Duodenal Biopsy Within Routine Upper Endoscopy: a Prospective Study in 1000 Patients]. Z Gastroenterol. 2008;46(8):771-5. PubMed PMID: 18759200.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The value of duodenal biopsy within routine upper endoscopy: a prospective study in 1000 patients]. AU - Tischendorf,J J W, AU - Wopp,K, AU - Streetz,K L, AU - Bach,J, AU - Meyer,M, AU - Tischendorf,S, AU - Gassler,N, AU - Koch,A, AU - Geier,A, AU - Wasmuth,H E, AU - Trautwein,C, AU - Winograd,R, PY - 2008/9/2/pubmed PY - 2008/11/19/medline PY - 2008/9/2/entrez SP - 771 EP - 5 JF - Zeitschrift fur Gastroenterologie JO - Z Gastroenterol VL - 46 IS - 8 N2 - BACKGROUND AND AIM: Several gastrointestinal diseases are localised in the small bowel and are confirmed by duodenal biopsies upon upper gastrointestinal endoscopy. However, the clinical value of routine duodenal biopsies during endoscopy has not been satisfactorily defined and was assessed in the current study. METHODS: In 1000 consecutive patients duodenal biopsies were performed during routine upper gastrointestinal endoscopy. Endoscopic diagnoses, symptoms and the prevalence of anaemia were correlated with the histological diagnoses. RESULTS: Coeliac disease and giardiasis was diagnosed in 18 and two patients, respectively (2.0 % of all cases). In 11 (55 %) patients the diagnosis was already made macroscopically during endoscopy. The sensitivity for endoscopic diagnosis of coeliac disease MARSH III was 84.6 %. There was no correlation between clinical symptoms, the prevalence of anaemia and the diagnosis of coeliac disease or giardiasis in our cohort. CONCLUSION: Endoscopic diagnosis of advanced celiac disease (MARSH III) can be made with high sensitivity and specifity. Nevertheless, duodenal biopsy is necessary for the diagnosis of early coeliac disease or giardiasis. However, the routine duodenal sampling of normal mucosa during gastrointestinal endoscopy cannot be recommended. SN - 0044-2771 UR - https://www.unboundmedicine.com/medline/citation/18759200/[The_value_of_duodenal_biopsy_within_routine_upper_endoscopy:_a_prospective_study_in_1000_patients]_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2008-1027407 DB - PRIME DP - Unbound Medicine ER -