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Impulse oscillometry in COPD: identification of measurements related to airway obstruction, airway conductance and lung volumes.
Respir Med 2009; 103(1):136-43RM

Abstract

BACKGROUND

Impulse oscillometry system (IOS) assesses pulmonary resistance and reactance. We set out to investigate which IOS measurements are related to airflow obstruction, airway conductance and lung volumes in chronic obstructive pulmonary disease (COPD).

METHODS

Ninety-four COPD patients were recruited and 58 agreed to follow up after 1 year. IOS measurements (R5, R20, X5 & Fres), body plethysmography (sGaw, FRC, TLC, RV & IC) and spirometry (FEV(1)) were performed. Pearson or Spearman correlation determined the relationships between IOS and other measurements.

RESULTS

R5, X5 and Fres were all significantly associated (p<0.05) with FEV(1), sGaw, TLC, RV and IC. However, R20 was not related to any of these measurements except for RV. The strongest associations were observed between FEV(1) and the reactance measurements X5 (r=0.48) and Fres (r=-0.44), and sGaw with X5 (r=0.47) and Fres (r=0.51). The r values for the associations with TLC and IC were all <0.25. There was no statistically significant change in the FEV(1), R5, X5 or Fres after 1 year, but R20 significantly increased over the year. The changes in R5 and R20 did not significantly correlate with the changes in FEV(1). In contrast, X5 changes were significantly related to FEV(1) changes over 1 year (r=-0.27, p=0.05), while for Fres changes there was a trend to statistical significance (p=0.08).

CONCLUSIONS

IOS reactance measurements are more closely related than resistance measurements to other pulmonary function measurements in COPD patients. The IOS reactance measurements appear to be indicative of changes in pulmonary compliance caused by airflow obstruction.

Authors+Show Affiliations

North West Lung Research Centre, University of Manchester, South Manchester University Hospitals Trust, Southmoor Road, Wythenshawe, Manchester M23 9LT, UK. ukolsum@meu.org.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

18760576

Citation

Kolsum, Umme, et al. "Impulse Oscillometry in COPD: Identification of Measurements Related to Airway Obstruction, Airway Conductance and Lung Volumes." Respiratory Medicine, vol. 103, no. 1, 2009, pp. 136-43.
Kolsum U, Borrill Z, Roy K, et al. Impulse oscillometry in COPD: identification of measurements related to airway obstruction, airway conductance and lung volumes. Respir Med. 2009;103(1):136-43.
Kolsum, U., Borrill, Z., Roy, K., Starkey, C., Vestbo, J., Houghton, C., & Singh, D. (2009). Impulse oscillometry in COPD: identification of measurements related to airway obstruction, airway conductance and lung volumes. Respiratory Medicine, 103(1), pp. 136-43. doi:10.1016/j.rmed.2008.07.014.
Kolsum U, et al. Impulse Oscillometry in COPD: Identification of Measurements Related to Airway Obstruction, Airway Conductance and Lung Volumes. Respir Med. 2009;103(1):136-43. PubMed PMID: 18760576.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impulse oscillometry in COPD: identification of measurements related to airway obstruction, airway conductance and lung volumes. AU - Kolsum,Umme, AU - Borrill,Zoë, AU - Roy,Kay, AU - Starkey,Cerys, AU - Vestbo,Jørgen, AU - Houghton,Catherine, AU - Singh,Dave, Y1 - 2008/08/28/ PY - 2008/01/30/received PY - 2008/07/08/revised PY - 2008/07/14/accepted PY - 2008/9/2/pubmed PY - 2009/2/10/medline PY - 2008/9/2/entrez SP - 136 EP - 43 JF - Respiratory medicine JO - Respir Med VL - 103 IS - 1 N2 - BACKGROUND: Impulse oscillometry system (IOS) assesses pulmonary resistance and reactance. We set out to investigate which IOS measurements are related to airflow obstruction, airway conductance and lung volumes in chronic obstructive pulmonary disease (COPD). METHODS: Ninety-four COPD patients were recruited and 58 agreed to follow up after 1 year. IOS measurements (R5, R20, X5 & Fres), body plethysmography (sGaw, FRC, TLC, RV & IC) and spirometry (FEV(1)) were performed. Pearson or Spearman correlation determined the relationships between IOS and other measurements. RESULTS: R5, X5 and Fres were all significantly associated (p<0.05) with FEV(1), sGaw, TLC, RV and IC. However, R20 was not related to any of these measurements except for RV. The strongest associations were observed between FEV(1) and the reactance measurements X5 (r=0.48) and Fres (r=-0.44), and sGaw with X5 (r=0.47) and Fres (r=0.51). The r values for the associations with TLC and IC were all <0.25. There was no statistically significant change in the FEV(1), R5, X5 or Fres after 1 year, but R20 significantly increased over the year. The changes in R5 and R20 did not significantly correlate with the changes in FEV(1). In contrast, X5 changes were significantly related to FEV(1) changes over 1 year (r=-0.27, p=0.05), while for Fres changes there was a trend to statistical significance (p=0.08). CONCLUSIONS: IOS reactance measurements are more closely related than resistance measurements to other pulmonary function measurements in COPD patients. The IOS reactance measurements appear to be indicative of changes in pulmonary compliance caused by airflow obstruction. SN - 1532-3064 UR - https://www.unboundmedicine.com/medline/citation/18760576/Impulse_oscillometry_in_COPD:_identification_of_measurements_related_to_airway_obstruction_airway_conductance_and_lung_volumes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0954-6111(08)00255-2 DB - PRIME DP - Unbound Medicine ER -