Tags

Type your tag names separated by a space and hit enter

Retinal vascular caliber and age-related macular degeneration: the Singapore Malay Eye Study.
Am J Ophthalmol. 2008 Dec; 146(6):954-9.e1.AJ

Abstract

PURPOSE

To investigate the relationship between retinal vascular caliber and age-related macular degeneration (AMD).

DESIGN

Population-based cross-sectional study.

METHODS

Three thousand two hundred and eighty (78.7% response rate) Malay Singaporeans aged 40 to 80 years residing in 15 districts of Singapore underwent retinal photography. Retinal vessel caliber was measured from retinal photographs using a validated computer-based technique. AMD was assessed following a modified Wisconsin Age-Related Maculopathy Grading System.

RESULTS

Retinal data were available from 3,265 subjects (99.5% of 3,280) for this study. Early and late AMD prevalence were 4.9% (n = 160) and 0.7% (n = 23) of the population, respectively, or in 205 (3.1%) and 30 (0.5%) eyes examined, respectively. After controlling for age and arteriolar caliber, wider venular caliber was associated with higher prevalence of early AMD (odds ratio [OR] per one standard deviation [SD] increment in venular caliber, 1.53; 95% confidence interval [CI], 1.13 to 2.09). This association remained significant after further adjustment for gender, smoking, hypertension, diabetes, and body mass index (OR per one SD, 1.52; 95% CI, 1.11 to 2.09). There was no significant association between retinal arteriolar caliber and early AMD, or between arteriolar or venular caliber and late AMD.

CONCLUSIONS

Wider venular caliber was associated independently with early AMD. This finding may suggest that pathogenic processes linking to wider venular caliber be shared by early AMD and common cardiovascular risk factors such as inflammation, dyslipidemia, and endothelial dysfunction.

Authors+Show Affiliations

Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18760764

Citation

Jeganathan, V Swetha E., et al. "Retinal Vascular Caliber and Age-related Macular Degeneration: the Singapore Malay Eye Study." American Journal of Ophthalmology, vol. 146, no. 6, 2008, pp. 954-9.e1.
Jeganathan VS, Kawasaki R, Wang JJ, et al. Retinal vascular caliber and age-related macular degeneration: the Singapore Malay Eye Study. Am J Ophthalmol. 2008;146(6):954-9.e1.
Jeganathan, V. S., Kawasaki, R., Wang, J. J., Aung, T., Mitchell, P., Saw, S. M., & Wong, T. Y. (2008). Retinal vascular caliber and age-related macular degeneration: the Singapore Malay Eye Study. American Journal of Ophthalmology, 146(6), 954-e1. https://doi.org/10.1016/j.ajo.2008.07.006
Jeganathan VS, et al. Retinal Vascular Caliber and Age-related Macular Degeneration: the Singapore Malay Eye Study. Am J Ophthalmol. 2008;146(6):954-9.e1. PubMed PMID: 18760764.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retinal vascular caliber and age-related macular degeneration: the Singapore Malay Eye Study. AU - Jeganathan,V Swetha E, AU - Kawasaki,Ryo, AU - Wang,Jie Jin, AU - Aung,Tin, AU - Mitchell,Paul, AU - Saw,Seang-Mei, AU - Wong,Tien Y, Y1 - 2008/08/30/ PY - 2008/03/20/received PY - 2008/06/28/revised PY - 2008/07/01/accepted PY - 2008/9/2/pubmed PY - 2008/12/18/medline PY - 2008/9/2/entrez SP - 954 EP - 9.e1 JF - American journal of ophthalmology JO - Am J Ophthalmol VL - 146 IS - 6 N2 - PURPOSE: To investigate the relationship between retinal vascular caliber and age-related macular degeneration (AMD). DESIGN: Population-based cross-sectional study. METHODS: Three thousand two hundred and eighty (78.7% response rate) Malay Singaporeans aged 40 to 80 years residing in 15 districts of Singapore underwent retinal photography. Retinal vessel caliber was measured from retinal photographs using a validated computer-based technique. AMD was assessed following a modified Wisconsin Age-Related Maculopathy Grading System. RESULTS: Retinal data were available from 3,265 subjects (99.5% of 3,280) for this study. Early and late AMD prevalence were 4.9% (n = 160) and 0.7% (n = 23) of the population, respectively, or in 205 (3.1%) and 30 (0.5%) eyes examined, respectively. After controlling for age and arteriolar caliber, wider venular caliber was associated with higher prevalence of early AMD (odds ratio [OR] per one standard deviation [SD] increment in venular caliber, 1.53; 95% confidence interval [CI], 1.13 to 2.09). This association remained significant after further adjustment for gender, smoking, hypertension, diabetes, and body mass index (OR per one SD, 1.52; 95% CI, 1.11 to 2.09). There was no significant association between retinal arteriolar caliber and early AMD, or between arteriolar or venular caliber and late AMD. CONCLUSIONS: Wider venular caliber was associated independently with early AMD. This finding may suggest that pathogenic processes linking to wider venular caliber be shared by early AMD and common cardiovascular risk factors such as inflammation, dyslipidemia, and endothelial dysfunction. SN - 1879-1891 UR - https://www.unboundmedicine.com/medline/citation/18760764/Retinal_vascular_caliber_and_age_related_macular_degeneration:_the_Singapore_Malay_Eye_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(08)00526-6 DB - PRIME DP - Unbound Medicine ER -