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Byrsonima fagifolia: an integrative study to validate the gastroprotective, healing, antidiarrheal, antimicrobial and mutagenic action.
J Ethnopharmacol. 2008 Nov 20; 120(2):149-60.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Ethnopharmacological survey indicated leaves of Byrsonima fagifolia Nied. (Malpighiaceae) against gastrointestinal disorders.

AIM OF THE STUDY

The methanolic extract from the leaves of Byrsonima fagifolia (denominated BF) was evaluated for toxic, mutagenic, gastroprotective, antidiarrheal, antibacterial and immunomodulatory activities.

MATERIALS AND METHODS

The preventive and healing action of BF against gastric ulcer was evaluated in experimental models in rodents. We evaluated immunomodulatory (by murine peritoneal macrophages), antidiarrheal (by induced diarrhea with castor oil and intestinal motility) and antibacterial action of BF against standard strain of Escherichia coli, Staphylococcus aureus and Helicobacter pylori. The safety of use of BF was also evaluated by mutagenic (Ames assay) and by analyses of toxicity parameters.

RESULTS

Phytochemical BF profile indicated the presence of phenolic compounds with antioxidant and radical-scavenging properties. BF significantly inhibited gastric lesions induced by ethanol and HCl/ethanol and endogenous mucosal sulphydryl groups (SHs) participated efficaciously in BF gastroprotection. BF blocked development of inflammation process and also has antidiarrheal actions. This extract accelerated the healing of the gastric ulcerated mucosa by stimulating proliferative factors and by increasing production of gastric mucus with no toxic action. The substances responsible for the protective action are concentrated in the ethyl acetate fraction that demonstrated no mutagenic action in vitro.

CONCLUSIONS

Byrsonima fagifolia presents gastroprotective, healing and antidiarrheal activities supporting previous claims that its traditional use by Brazilians can treat these gastrointestinal ailments.

Authors+Show Affiliations

São Paulo State University, Departamento de Fisiologia, Instituto de Biociências, cp 610, CEP 18618-000, UNESP, Botucatu, SP, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18761075

Citation

Lima, Zeila Pinheiro, et al. "Byrsonima Fagifolia: an Integrative Study to Validate the Gastroprotective, Healing, Antidiarrheal, Antimicrobial and Mutagenic Action." Journal of Ethnopharmacology, vol. 120, no. 2, 2008, pp. 149-60.
Lima ZP, dos Santos Rde C, Torres TU, et al. Byrsonima fagifolia: an integrative study to validate the gastroprotective, healing, antidiarrheal, antimicrobial and mutagenic action. J Ethnopharmacol. 2008;120(2):149-60.
Lima, Z. P., dos Santos, R. d. e. . C., Torres, T. U., Sannomiya, M., Rodrigues, C. M., dos Santos, L. C., Pellizzon, C. H., Rocha, L. R., Vilegas, W., Souza Brito, A. R., Cardoso, C. R., Varanda, E. A., de Moraes, H. P., Bauab, T. M., Carli, C., Carlos, I. Z., & Hiruma-Lima, C. A. (2008). Byrsonima fagifolia: an integrative study to validate the gastroprotective, healing, antidiarrheal, antimicrobial and mutagenic action. Journal of Ethnopharmacology, 120(2), 149-60. https://doi.org/10.1016/j.jep.2008.07.047
Lima ZP, et al. Byrsonima Fagifolia: an Integrative Study to Validate the Gastroprotective, Healing, Antidiarrheal, Antimicrobial and Mutagenic Action. J Ethnopharmacol. 2008 Nov 20;120(2):149-60. PubMed PMID: 18761075.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Byrsonima fagifolia: an integrative study to validate the gastroprotective, healing, antidiarrheal, antimicrobial and mutagenic action. AU - Lima,Zeila Pinheiro, AU - dos Santos,Raquel de Cássia, AU - Torres,Talita Uliana, AU - Sannomiya,Miriam, AU - Rodrigues,Clenilson Martins, AU - dos Santos,Lourdes Campaner, AU - Pellizzon,Cláudia Helena, AU - Rocha,Lúcia Regina Machado, AU - Vilegas,Wagner, AU - Souza Brito,Alba Regina Monteiro, AU - Cardoso,Cássia Regina Primila, AU - Varanda,Eliana Aparecida, AU - de Moraes,Helen Pimenta, AU - Bauab,Taís Maria, AU - Carli,Camila, AU - Carlos,Iracilda Zeppone, AU - Hiruma-Lima,Clélia Akiko, Y1 - 2008/08/08/ PY - 2008/05/06/received PY - 2008/07/25/revised PY - 2008/07/31/accepted PY - 2008/9/2/pubmed PY - 2009/2/14/medline PY - 2008/9/2/entrez SP - 149 EP - 60 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 120 IS - 2 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Ethnopharmacological survey indicated leaves of Byrsonima fagifolia Nied. (Malpighiaceae) against gastrointestinal disorders. AIM OF THE STUDY: The methanolic extract from the leaves of Byrsonima fagifolia (denominated BF) was evaluated for toxic, mutagenic, gastroprotective, antidiarrheal, antibacterial and immunomodulatory activities. MATERIALS AND METHODS: The preventive and healing action of BF against gastric ulcer was evaluated in experimental models in rodents. We evaluated immunomodulatory (by murine peritoneal macrophages), antidiarrheal (by induced diarrhea with castor oil and intestinal motility) and antibacterial action of BF against standard strain of Escherichia coli, Staphylococcus aureus and Helicobacter pylori. The safety of use of BF was also evaluated by mutagenic (Ames assay) and by analyses of toxicity parameters. RESULTS: Phytochemical BF profile indicated the presence of phenolic compounds with antioxidant and radical-scavenging properties. BF significantly inhibited gastric lesions induced by ethanol and HCl/ethanol and endogenous mucosal sulphydryl groups (SHs) participated efficaciously in BF gastroprotection. BF blocked development of inflammation process and also has antidiarrheal actions. This extract accelerated the healing of the gastric ulcerated mucosa by stimulating proliferative factors and by increasing production of gastric mucus with no toxic action. The substances responsible for the protective action are concentrated in the ethyl acetate fraction that demonstrated no mutagenic action in vitro. CONCLUSIONS: Byrsonima fagifolia presents gastroprotective, healing and antidiarrheal activities supporting previous claims that its traditional use by Brazilians can treat these gastrointestinal ailments. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/18761075/Byrsonima_fagifolia:_an_integrative_study_to_validate_the_gastroprotective_healing_antidiarrheal_antimicrobial_and_mutagenic_action_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(08)00425-X DB - PRIME DP - Unbound Medicine ER -