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[Interaction of the polymorphism of vitamin D receptor gene start codon with physical activity on bone mass accrual in Chinese adolescent girls].
Zhonghua Yu Fang Yi Xue Za Zhi. 2008 Apr; 42(4):239-43.ZY

Abstract

OBJECTIVE

To investigate the association between the polymorphism of vitamin D receptor (VDR) gene start codon (Fok I) and bone mass accrual, and assessing if such an association could be modified by physical activity in Chinese adolescent girls.

METHODS

A total of 228 premenrche Chinese girls (9-11.5-years-old) were recruited for 2-year study. Bone mineral densities (BMD) at the total body, total left hip (including femoral neck, trochanter, intertrochanteric and Ward's triangle area) and lumbar spine (L1-L4) were measured by dual energy X-ray absorptiometry. The Fok I polymorphism of VDR gene was detected with PCR-RFLP.

RESULTS

There remained 176 available subjects in our cohort when 2-year study was completed. No significant association was observed between Fok I polymorphism of VDR gene and percentage change in BMD at all sites. Girls with FF genotype had lower percentage change in total left hip BMD (THBMD) and femoral neck BMD (FNBMD) than girls with Ff + ff genotype only in low physical activity(< 1197 kJ/d), and physical activity was associated with percentage change in THBMD and FNBMD only in FF genotype group.

CONCLUSION

The Fok I polymorphism of VDR gene should have significant interaction effect with physical activity on bone mass accrual in Chinese adolescent girls. Girls with FF genotype in low physical activity would be the potential risk population for low bone mass accrual, and high physical activity would be of benefit to gain higher bone mass accrual for girls with FF genotype.

Links

Publisher Full Text

Authors+Show Affiliations

Li X
Faculty of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China.
He GP
No affiliation info available
Su YX
No affiliation info available

MeSH

AdolescentAllelesBone DensityChinaCodon, InitiatorExerciseFemaleGenotypeHumansPolymorphism, Restriction Fragment LengthReceptors, Calcitriol

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

18763633

Citation

Li, Xing, et al. "[Interaction of the Polymorphism of Vitamin D Receptor Gene Start Codon With Physical Activity On Bone Mass Accrual in Chinese Adolescent Girls]." Zhonghua Yu Fang Yi Xue Za Zhi [Chinese Journal of Preventive Medicine], vol. 42, no. 4, 2008, pp. 239-43.
Li X, He GP, Su YX. [Interaction of the polymorphism of vitamin D receptor gene start codon with physical activity on bone mass accrual in Chinese adolescent girls]. Zhonghua Yu Fang Yi Xue Za Zhi. 2008;42(4):239-43.
Li, X., He, G. P., & Su, Y. X. (2008). [Interaction of the polymorphism of vitamin D receptor gene start codon with physical activity on bone mass accrual in Chinese adolescent girls]. Zhonghua Yu Fang Yi Xue Za Zhi [Chinese Journal of Preventive Medicine], 42(4), 239-43.
Li X, He GP, Su YX. [Interaction of the Polymorphism of Vitamin D Receptor Gene Start Codon With Physical Activity On Bone Mass Accrual in Chinese Adolescent Girls]. Zhonghua Yu Fang Yi Xue Za Zhi. 2008;42(4):239-43. PubMed PMID: 18763633.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Interaction of the polymorphism of vitamin D receptor gene start codon with physical activity on bone mass accrual in Chinese adolescent girls]. AU - Li,Xing, AU - He,Guo-peng, AU - Su,Yi-xiang, PY - 2008/9/4/pubmed PY - 2009/5/27/medline PY - 2008/9/4/entrez SP - 239 EP - 43 JF - Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] JO - Zhonghua Yu Fang Yi Xue Za Zhi VL - 42 IS - 4 N2 - OBJECTIVE: To investigate the association between the polymorphism of vitamin D receptor (VDR) gene start codon (Fok I) and bone mass accrual, and assessing if such an association could be modified by physical activity in Chinese adolescent girls. METHODS: A total of 228 premenrche Chinese girls (9-11.5-years-old) were recruited for 2-year study. Bone mineral densities (BMD) at the total body, total left hip (including femoral neck, trochanter, intertrochanteric and Ward's triangle area) and lumbar spine (L1-L4) were measured by dual energy X-ray absorptiometry. The Fok I polymorphism of VDR gene was detected with PCR-RFLP. RESULTS: There remained 176 available subjects in our cohort when 2-year study was completed. No significant association was observed between Fok I polymorphism of VDR gene and percentage change in BMD at all sites. Girls with FF genotype had lower percentage change in total left hip BMD (THBMD) and femoral neck BMD (FNBMD) than girls with Ff + ff genotype only in low physical activity(< 1197 kJ/d), and physical activity was associated with percentage change in THBMD and FNBMD only in FF genotype group. CONCLUSION: The Fok I polymorphism of VDR gene should have significant interaction effect with physical activity on bone mass accrual in Chinese adolescent girls. Girls with FF genotype in low physical activity would be the potential risk population for low bone mass accrual, and high physical activity would be of benefit to gain higher bone mass accrual for girls with FF genotype. SN - 0253-9624 UR - https://www.unboundmedicine.com/medline/citation/18763633/[Interaction_of_the_polymorphism_of_vitamin_D_receptor_gene_start_codon_with_physical_activity_on_bone_mass_accrual_in_Chinese_adolescent_girls]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0253-9624&amp;year=2008&amp;vol=42&amp;issue=4&amp;fpage=239 DB - PRIME DP - Unbound Medicine ER -